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The Lambrechts Lab @lambrechtslab.bsky.social · 5d

🚨 New preprint alert! We have developed a targeted amplicon sequencing panel for Aedes aegypti. We believe it is a powerful and cost-effective tool for studying #mosquito #population #genetics. Curious how it matches up to WGS? Check out our preprint to find out! www.biorxiv.org/content/10.1...

A targeted amplicon sequencing panel for cost-effective high-throughput genotyping of Aedes aegypti

The mosquito Aedes aegypti is the primary vector for several medically significant arboviruses, including dengue, Zika, chikungunya, and yellow fever. Studying the genetic diversity of Ae. aegypti is ...

www.biorxiv.org

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Reposted by The Lambrechts Lab

Ben Longdon @blongdon.bsky.social · 13d

2 job adverts on a NERC project w myself + @darrenobbard.bsky.social on “What determines the virome: ecology and the environment, evolution, or species history?” early 2026 in
@uniexecec.bsky.social
- Postdoc: jobs.exeter.ac.uk/hrpr_webrecr...
- RA: jobs.exeter.ac.uk/hrpr_webrecr...
Pls share!

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Reposted by The Lambrechts Lab

Princeton University @princeton.edu · 16d

A study by researchers at Princeton, @pasteur.fr, and @ucsandiego.bsky.social reveals that Africa’s low rates of Zika virus outbreaks may be due to a surprising factor: the genetic makeup of local mosquito populations.

Mosquito Genetics May Explain Why Zika Virus Outbreaks Are Rare in Africa – But Climate Change Could Shift the Balance - High Meadows Environmental Institute

A new study reveals that Africa’s low rates of Zika virus outbreaks may be due to a surprising factor: the genetic makeup of local mosquito populations. Research by scientists at the High Meadows Envi...

environment.princeton.edu

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The Lambrechts Lab @lambrechtslab.bsky.social · 13d

Huge thanks to @gonzalezlabbcn.bsky.social for her invaluable contribution as a member of Alexander Bergman's PhD jury and for the stimulating discussions that ensued. It was a great opportunity to chat about #transposons in #mosquitoes and #Drosophila!

Josefa González @gonzalezlabbcn.bsky.social · 13d

Discussing mosquitoes and fruitflies #transposons with @lambrechtslab.bsky.social lab at @pasteur.fr. Great science in a great place. Congrats to the new @sorbonne-universite.fr Doctor Alexander Bergman!

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The Lambrechts Lab @lambrechtslab.bsky.social · 18d

WOW! Systematic testing of 2 #Wolbachia strains for their ability to block transmission of 60 genetically diverse #DENV isolates in #mosquitoes shows substantial heterogeneity and suggests potential long-term selection risks in Wolbachia-based control interventions.

Chantal Vogels @chantalvogels.bsky.social · 19d

📢New preprint on the impact of dengue virus genetic diversity on inhibition by Wolbachia 🦟🦠🧬

Project led by Afeez Sodeinde, @emiliefinch.bsky.social, and @keli5734.bsky.social! ✨

Key findings in thread below 👇

www.biorxiv.org/content/10.1...

Heterogeneity in inhibition of genetically diverse dengue virus strains by Wolbachia

The release of Aedes aegypti mosquitoes transinfected with the virus-inhibiting Wolbachia bacterium has the potential to reduce the burden caused by dengue virus (DENV). However, the robustness of thi...

www.biorxiv.org

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Reposted by The Lambrechts Lab

Erica McAlister @flygirlnhm.bsky.social · 19d

www.nhm.ac.uk/discover/new...

Mosquitoes that have been in the collection for nearly a hundred years are helping us in dealing with an even older but also current problem - malaria

@sangerinstitute.bsky.social @nhm-london.bsky.social

Genetic study of malaria-carrying mosquitoes tracks evolution of insecticide resistance | Natural History Museum

It crucially also reveals promising genetic targets for potential control.

www.nhm.ac.uk

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The Lambrechts Lab @lambrechtslab.bsky.social · 19d

How the yellow fever mosquito conquered the world | Science | AAAS www.science.org/content/arti...

How the yellow fever mosquito conquered the world

Aedes aegypti further adapted to life around humans when it arrived in the Americas, study of hundreds of mosquito genomes reveals

www.science.org

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The Lambrechts Lab @lambrechtslab.bsky.social · 19d

Genomic clues into the spread of deadly mosquitoes | Science www.science.org/doi/10.1126/...

Genomic clues into the spread of deadly mosquitoes

Ancient and more recent human interactions shape mosquito vector evolution

www.science.org

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Reposted by The Lambrechts Lab

Vasilakis Lab @vasilakislab.bsky.social · 20d

1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk | Science www.science.org/doi/10.1126/....

A seminal paper of great interest to all. Great work and congratulations to the team!

1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk

The emergence and global expansion of Aedes aegypti puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovi...

www.science.org

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Reposted by The Lambrechts Lab

Didier Mazel @amazeld.bsky.social · 19d

Striking and frightening 😒 "They found multiple instances of insecticide-resistance variants in this malaria vector, although most of these weren’t shared with museum specimens collected as recently as 1967, suggesting rapid emergence"
www.science.org/doi/10.1126/...

Genomic diversity of the African malaria vector Anopheles funestus

Anopheles funestus s.s. is a major human malaria vector across Africa. To study its evolution, especially under vector control pressure, we sequenced 656 modern specimens (collected 2014 to 2018) and ...

www.science.org

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The Lambrechts Lab @lambrechtslab.bsky.social · 19d

ScienceAdviser: Mosquitoes seem to love hedonists | Science | AAAS www.science.org/content/arti...

ScienceAdviser: Mosquitoes seem to love hedonists

Today in Science and science: How corpse flowers make a big stink, a rocky start for the ocean, and more

www.science.org

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Reposted by The Lambrechts Lab

Le Monde @lemonde.fr · 21d

Chikungunya : forte hausse des cas autochtones en métropole, Santé publique France appelle à la vigilance face aux moustiques tigres

L’implantation du moustique tigre dans 81 départements métropolitains inquiète les autorités, qui redoutent une propagation accrue du chikungunya et d’autres maladies vectorielles cet automne.

www.lemonde.fr

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Reposted by The Lambrechts Lab

Nature @nature.com · 22d

Brazil hopes to turn the tide of dengue with a home-grown vaccine and an army of mosquitoes

go.nature.com/41VWT1V

How billions of hacked mosquitoes and a vaccine could beat the deadly dengue virus

Outbreaks of dengue are killing thousands of people in South America each year and getting worse. Brazil hopes to turn the tide with a home-grown vaccine and an army of mosquitoes infected with Wolbachia bacteria.

go.nature.com

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The Lambrechts Lab @lambrechtslab.bsky.social · 26d

Mosquito-borne viruses surge in a warming Europe | Science | AAAS www.science.org/content/arti...

Mosquito-borne viruses surge in a warming Europe

Chikungunya cases break records in France; West Nile virus appears near Rome

www.science.org

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Reposted by The Lambrechts Lab

Sarah Merkling @merklinglab.bsky.social · Sep 1

@elodiecouderc.bsky.social is on 🔥 this month ! Our review (which the literature really missed, imho) giving an historical perspective on the methods used to study of mosquito-virus interactions in now online at @cp-trendsmicrobiol.bsky.social. Check it ou here: www.cell.com/trends/micro...

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Reposted by The Lambrechts Lab

Sarah Merkling @merklinglab.bsky.social · Sep 8

Virology lost one of his monuments, David Baltimore. To learn more about him and his contributions, I recommend (re)-listening to this great TWIV episode : www.microbe.tv/twiv/twiv-10...

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Reposted by The Lambrechts Lab

Elodie Couderc @elodiecouderc.bsky.social · Aug 29

New #review out 🚨 for mosquito enthusiasts 🦟 !

Have you ever questioned the approach you routinely use to investigate #mosquito-virus #interactions? ⬇️

www.sciencedirect.com/science/arti...

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The Lambrechts Lab @lambrechtslab.bsky.social · Aug 28

Does #dengue virus hijack #mosquitoes' brain? Study led by Felix Hol @pasteur.fr discovered that infected mosquitoes take smaller blood meals. As a result, they bite more often, and potentially infect infect more people.

(video in French with English subtitles available)
youtu.be/2u_qckfAQa4?...

La dengue aux commandes

YouTube video by Institut Pasteur

youtu.be

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Reposted by The Lambrechts Lab

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 26

Blood, sweat, and beers: investigating mosquito biting preferences amidst noise and intoxication in a cross-sectional cohort study at a large music festival https://www.biorxiv.org/content/10.1101/2025.08.21.671470v1

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Reposted by The Lambrechts Lab

Elodie Couderc @elodiecouderc.bsky.social · Aug 27

🚀 Excited to share (with a little delay) my first first-author publication on #Vago genes in #mosquitoes! 🦟 🦠 Have a look to see how we questioned a mosquito immunity dogma and challenged the existing understanding of Vago-like genes as antiviral factors ⬇️

bmcbiol.biomedcentral.com/articles/10....

Aedes aegypti VLG-1 challenges the assumed antiviral nature of Vago genes - BMC Biology

Background Arthropod-borne viruses (arboviruses) such as dengue virus (DENV) and Zika virus (ZIKV) pose a significant threat to global health. Novel approaches to control the spread of arboviruses foc...

bmcbiol.biomedcentral.com

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The Lambrechts Lab @lambrechtslab.bsky.social · Aug 18

Our discovery suggests a mechanistic link between DENV susceptibility and insecticide resistance. Cytochrome P450 enzymes, known drivers of such resistance in mosquitoes, add complexity to this interaction and highlight new research avenues.

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The Lambrechts Lab @lambrechtslab.bsky.social · Aug 18

Through infection assays, transcriptomics, gene silencing, and transgenesis, we have identified the CYP4G15 gene as a key player. Variants in its promoter significantly impact DENV infection in Ae. aegypti, marking the 1st definitive identification of genetic variants linked to DENV susceptibility.

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The Lambrechts Lab @lambrechtslab.bsky.social · Aug 18

Despite decades of research focusing mostly on immune genes, causal genetic variants for DENV susceptibility in mosquitoes have been hard to pin down. Our work instead spotlights how metabolic pathways—specifically, cytochrome P450 enzymes—play a key role in shaping mosquito-virus interactions.

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The Lambrechts Lab @lambrechtslab.bsky.social · Aug 18

🦟🦠 Check out our latest article in @natcomms.nature.com on the genetic basis of #dengue virus susceptibility in #mosquitoes! Collaborative work brillantly led by @merklinglab.bsky.social and @elodiecouderc.bsky.social @pasteur.fr and primarily supported by @agencerecherche.bsky.social rdcu.be/eBbg7

Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 promoter variants

Nature Communications - Genetic factors affecting Aedes aegypti susceptibility to dengue virus infection aren’t well studied. Here the authors show that a cytochrome P450 gene, typically...

rdcu.be

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Reposted by The Lambrechts Lab

Cassandra Koh 🦟🔬🧪 @cassandrakoh.bsky.social · Jul 28

📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠
🗓️ Application deadline 31 August 2025

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