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Sarah Merkling

@merklinglab.bsky.social

1.4K followers 1.4K following 53 posts

We are all about mosquitoes, viruses and single cells! Insect Infection and Immunity - Merkling Lab @CNRS.fr @Pasteur.fr @ERC.europa.eu #newPI #DiversityEquityInclusion #ally 🏳️‍🌈🏳️‍⚧️ https://aedes-cell-atlas.pasteur.cloud/

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Sarah Merkling @merklinglab.bsky.social · Aug 18

Our study is now published in @natcomms.nature.com and describes the 1st definitive identification of genetic variants linked to DENV susceptibility in Aedes aegypti mosquitoes. (1/3)

The Lambrechts Lab @lambrechtslab.bsky.social · Aug 18

🦟🦠 Check out our latest article in @natcomms.nature.com on the genetic basis of #dengue virus susceptibility in #mosquitoes! Collaborative work brillantly led by @merklinglab.bsky.social and @elodiecouderc.bsky.social @pasteur.fr and primarily supported by @agencerecherche.bsky.social rdcu.be/eBbg7

Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 promoter variants

Nature Communications - Genetic factors affecting Aedes aegypti susceptibility to dengue virus infection aren’t well studied. Here the authors show that a cytochrome P450 gene, typically...

rdcu.be

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Reposted by Sarah Merkling

Dr Elodie Chabrol @eloscicomm.bsky.social · 15d

👩‍🔬J'ai commencé un kit de démarrage "chercheuses en France" go.bsky.app/TBEzKC #FemmesEnScience

J'ai besoin de votre aide pour le remplir et donner de la visibilité aux chercheuses que vous connaissez et qui sont sur Bluesky !
▶️Taguez celles que vous connaissez, je les ajoute !

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Sarah Merkling @merklinglab.bsky.social · Sep 8

Virology lost one of his monuments, David Baltimore. To learn more about him and his contributions, I recommend (re)-listening to this great TWIV episode : www.microbe.tv/twiv/twiv-10...

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Sarah Merkling @merklinglab.bsky.social · Sep 1

@elodiecouderc.bsky.social is on 🔥 this month ! Our review (which the literature really missed, imho) giving an historical perspective on the methods used to study of mosquito-virus interactions in now online at @cp-trendsmicrobiol.bsky.social. Check it ou here: www.cell.com/trends/micro...

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Reposted by Sarah Merkling

Athene Donald @athenedonald.bsky.social · Aug 30

RIP Margaret Rossiter, who coined the phrase the Matilda Effect (amongst many others), a phenomenon too many women will have seen first hand

Will Thomas @williamthomas.bsky.social · Aug 30

Good to see the New York Times has a lengthy obituary for Margaret Rossiter

Margaret W. Rossiter, 81, Dies; Wrote Women Scientists Into History

www.nytimes.com

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Sarah Merkling @merklinglab.bsky.social · Aug 28

Thank you to our funders @pasteur.fr @ibeidlabex.bsky.social @sorbonne-universite.fr @agencerecherche.bsky.social @cnrsecologie.bsky.social for supporting our work!

Sarah Merkling @merklinglab.bsky.social · Aug 28

👏So proud to share @elodiecouderc.bsky.social work on the role of Vago-like genes in mosquito immunity. Please read her thread to get a sneak-peek of our work and find the full study here: rdcu.be/eCPmG

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Sarah Merkling @merklinglab.bsky.social · Aug 19

Yes! This is cytochrome P4503A4 - it is a very large family and their activity spans from detoxification, metabolism and many more cellular processes. In our case, the exact mechanism linking our P450 with dengue virus is unknown - might be metabolism (my first guess), or something else ...

Sarah Merkling @merklinglab.bsky.social · Aug 19

Thank you Alain!

Sarah Merkling @merklinglab.bsky.social · Aug 19

Thank you Olaya !

Sarah Merkling @merklinglab.bsky.social · Aug 19

Thank you ! So much more work to do indeed :)

Sarah Merkling @merklinglab.bsky.social · Aug 18

This was one of the most exciting, exploratory, long and difficult project I ever got to work on and I thank everyone who contributed, shared ideas and asked questions about it at meetings. Thanks to our funders @pasteur.fr @agencerecherche.bsky.social for their continuous support !

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Sarah Merkling @merklinglab.bsky.social · Aug 18

It also raises new questions about the role of metabolism in DENV infection and the unexplored/mysterious link between DENV susceptibility and insecticide resistance. (2/3)

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Sarah Merkling @merklinglab.bsky.social · Aug 18

Our study is now published in @natcomms.nature.com and describes the 1st definitive identification of genetic variants linked to DENV susceptibility in Aedes aegypti mosquitoes. (1/3)

The Lambrechts Lab @lambrechtslab.bsky.social · Aug 18

Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 promoter variants

Nature Communications - Genetic factors affecting Aedes aegypti susceptibility to dengue virus infection aren’t well studied. Here the authors show that a cytochrome P450 gene, typically...

rdcu.be

3 10 30

Reposted by Sarah Merkling

Trends in Parasitology @cp-trendsparasitol.bsky.social · Aug 13

David Hall & @vectorimmunity.bsky.social highlight @merklinglab.bsky.social & colleagues’ Cell Genomics article on #mosquito cellular responses in #midgut & #fatbody after #bloodfeeding. #Aedes #aegypti #scRNAseq #Metabolomics @iastateresearch.bsky.social‬ ‬

authors.elsevier.com/a/1lbEr5Eb1x...

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Reposted by Sarah Merkling

Allen Tien, MD, MHS mdlogix.com 94,698 田一彦 @allentien.bsky.social · Jul 14

go.bsky.app/36RdG8Z

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Reposted by Sarah Merkling

Institut Pasteur | 130 years of biomedical research @pasteur.fr · Jun 30

🌈 United for diversity in science 🌈
Researchers from Institut Pasteur joined the 2025 Pride March alongside @institutcurie.bsky.social, Les Cordeliers Research Center, @institutcochin.bsky.social @institutimagine.bsky.social

👩‍🔬 Because diverse labs make better science.
#DiversityInScience

4 research institute march together hand in hand for diversity and inclusion in science © Franck Aubry

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Sarah Merkling @merklinglab.bsky.social · Jun 26

🎉 Our study is now published in Cell Genomics ! Thank to our reviewers for helping us further improve our work, and congratulations to @tompvial.bsky.social who lead this project and the entire team that made it possible ! www.cell.com/cell-genomic...

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Sarah Merkling @merklinglab.bsky.social · Jun 4

Awesome post-doc position available within the @maringerlab.bsky.social ! I can highly recommend applying to @pirbrightinst.bsky.social - Kevin and Trevor are wonderful PI's to be working with !

Kevin Maringer (he/they) 🏳️‍🌈♾️ @maringerlab.bsky.social · Jun 4

We have a postdoc position available in which we’re using flavivirus replication/molecular biology to make refractory mosquitoes - in collaboration with the Trevor Sweeney lab at @pirbrightinst.bsky.social. Check out the advert on LinkedIn and apply by 12/6.

www.linkedin.com/jobs/view/42...

The Pirbright Institute hiring Postdoctoral Researcher in Woking, England, United Kingdom | LinkedIn

Posted 1:09:44 PM. Postdoctoral Researcher – (24P-73)The Pirbright Institute Salary: £38,5000 to 40,000 per annum36…See this and similar jobs on LinkedIn.

www.linkedin.com

Reposted by Sarah Merkling

European Research Council (ERC) @erc.europa.eu · Jun 2

Planning to apply for #research #funding from the ERC?

From the next application rounds, expect changes to the:

• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)

More 👇 europa.eu/!RPHWvv

Changes to the 2026 and 2027 Work Programmes

With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

europa.eu

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Sarah Merkling @merklinglab.bsky.social · May 29

Had the pleasure of listening to @ardemp.bskyverified.social’s lecture yesterday at @pasteur.fr - and seeing a live demonstration of the Piezo tattoo !

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Reposted by Sarah Merkling

Ardem Patapoutian @ardemp.bskyverified.social · May 28

Wrapped up a 4 seminar Tour de 🇫🇷 with stops in Lyon, Strasbourg, and Paris (IBPS, Pasteur). Had a blast with fellow scientists across the pond, lots of convo about the current US landscape. You might recognize Jean-Marie Lehn, Jean-Pierre Changeux, and Christine Petit. Also: white asparagus season!

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Reposted by Sarah Merkling

European Commission @ec.europa.eu · May 8

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

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Sarah Merkling @merklinglab.bsky.social · May 19

Had a wonderful time at the #EMBLChromatin meeting in Heidelberg last week with @sumeyye-ozhan.bsky.social who was sponsored by a @pasteur.fr - @events.embl.org travel award ! @sebbaumgarten.bsky.social ;)

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Sarah Merkling @merklinglab.bsky.social · May 19

Congratulations on getting the poster prize !! 🥳
Also very nice meeting you at the conference :)

Reposted by Sarah Merkling

Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · May 18

@sebbontempsgallo.bsky.social , Chercheur @cnrs-hautsdefrance.bsky.social @cnrsbiologie.bsky.social

Maladie de #Lyme : comment s’en protéger ?

Maladie de Lyme : comment s’en protéger ? - Sébastien Bontemps Gallo - 10' de prév'

YouTube video by Pasteur Lille

www.youtube.com

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