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Laurent Sheybani @laurentsheybani.bsky.social · 5d

🚨 Great scientific commentary by Christos Lisgaras --> academic.oup.com/braincomms/a...

High frequency oscillations in neurodegenerative disorders. Have a look !

High frequency opportunities for Alzheimer’s disease

This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o

academic.oup.com

Laurent Sheybani @laurentsheybani.bsky.social · 23d

The project is planned for 3 years in collaboration with Prof. @anitaluthi.bsky.social (UNIL) and Prof. Serge Vulliémoz (UNIGE). Funded by the @snsf.ch

Laurent Sheybani @laurentsheybani.bsky.social · 23d

The project builds upon my recent publications in Nature Communications (doi: doi.org/10.1038/s414...), Neurology (doi: doi.org/10.1212/WNL....) and Nature Reviews Neurology (doi: doi.org/10.1038/s415...).

💡🧠⚙️🔬💡
If you are curious to know more about epilepsy and sleep, check the call !

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Laurent Sheybani @laurentsheybani.bsky.social · 23d

We are hiring !

👩🏼‍🎓👨‍🎓🧑🏼‍🎓👨🏿‍🎓👩🏿‍🎓👩‍🎓

I am looking for a motivated person interested in a PhD in basic neuroscience, for a project at the edge between epilepsy and sleep.

If you are interested, check the job announcement:
jobs.unige.ch/www/wd_porta...

Assistant-e (A2) (6548)

jobs.unige.ch

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Reposted by Laurent Sheybani

Epilepsia Journal @epilepsiajournal.bsky.social · Jul 16

This asymmetry is highly patient-specific and supports the hypothesis that generalized discharges are shaped by delimited areas of cortex.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #amplitude #discharges #EEG #generalized #symmetry

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Laurent Sheybani @laurentsheybani.bsky.social · Jul 12

A big thank to the @snsf.ch, Geneva University (UNIGE), University Hospitals of Geneva (HUG) and @unil.bsky.social

Laurent Sheybani @laurentsheybani.bsky.social · Jul 12

For this project, a PhD and postdoc position will open ! If you are interested in epilepsy and sleep, STAY TUNED !!

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Laurent Sheybani @laurentsheybani.bsky.social · Jul 12

Thrilled to have been awarded an Ambizione grant from the @snsf.ch ! I will work under the auspices of Pr Serge Vulliémoz, Pr @anitaluthi.bsky.social and collaborate with Pr Matthew Walker (UCL), Dr Daniel Bush and Dr Tawfeeq Shekh-Ahmad for a project on epilepsy and sleep.

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Laurent Sheybani @laurentsheybani.bsky.social · May 30

Deep learning for epilepsy ! An impressive work by Sundrani and colleagues demonstrates the ability of convulational neural network to predict seizure onset zones -->
doi.org/10.1111/epi....

Deep learning on brief interictal intracranial recordings can accurately characterize seizure onset zones

Objective Epilepsy is a debilitating disorder affecting more than 50 million people worldwide, and one third of patients continue to have seizures despite maximal medical management. If patients' se...

doi.org

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Laurent Sheybani @laurentsheybani.bsky.social · May 30

Interneurons promotes microglial activation, ultimately leading to phagocytosis of inhibitory synapses --> part of the mechanism of temporal lobe epilepsy?
doi.org/10.1038/s415...

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy - Nature Neuroscience

The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driv...

doi.org

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Reposted by Laurent Sheybani

Katrijn Schruers @katschruers.bsky.social · May 21

Just published my first paper!
Really grateful to everyone at the plasticity lab @oxcin.bsky.social who made this possible.

huge thanks to my co-authors — couldn’t have done it without you.

If you want to check it out:
📄 paper: www.nature.com/articles/s41...

Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis - Scientific Reports

Scientific Reports - Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis

www.nature.com

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Reposted by Laurent Sheybani

Pierre Mégevand @vanmedge.bsky.social · May 19

Pint of Science in Geneva! This week. Program here: pintofscience.ch/events/geneva

@pintofscience.ch

Geneva

Explore Pint of Science Switzerland events in Geneva

pintofscience.ch

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Laurent Sheybani @laurentsheybani.bsky.social · May 9

Made me think of your paper:
www.science.org/doi/10.1126/...

Coordinated infraslow neural and cardiac oscillations mark fragility and offline periods in mammalian sleep

Mammalian sleep alternates between sensory-responsive and protected offline periods via coordinated neural and cardiac rhythms.

www.science.org

Laurent Sheybani @laurentsheybani.bsky.social · May 9

doi.org/10.1038/s415...
@anitaluthi.bsky.social

Autonomic physiological coupling of the global fMRI signal - Nature Neuroscience

The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

doi.org

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Laurent Sheybani @laurentsheybani.bsky.social · Apr 20

Thorough electrophy study on cortical stimulation --> www.nature.com/articles/s41....
Fascinating to see this complex network elicited by 'artificial' stimulation.
Well done @simonerusso.bsky.social and team!

Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans - Nature Communications

Neural mechanisms underlying thalamic contributions to evoked potentials by brain stimulation, which has been widely used for therapeutic interventions, are not fully understood. In this translational...

www.nature.com

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Laurent Sheybani @laurentsheybani.bsky.social · Mar 31

Encouraging phase 2 trial in fronto-temporal dementia ->

Brain Communications @braincomms.bsky.social · Mar 31

Assogna et al. report that co-ultramicronised palmitoylethanolamide + luteoline slowed cognitive decline in FTD patients in a Phase 2 trial, showing promise for future treatment. Please read at: buff.ly/VlC9Kdd #FTD

Laurent Sheybani @laurentsheybani.bsky.social · Mar 25

Excited to take part in tomorrow's webinar organized by the Young Epilepsy Session (YES) of the International League Against Epilepsy (ILAE). I will be discussing mechanisms of generation of HFOs and why this is important for clinical practice.
@ilae-epilepsy.bsky.social

Christos Lisgaras @chrislisgaras.bsky.social · Mar 21

Join us next week for an @ilae-epilepsy.bsky.social webinar on High Frequency Oscillations! Dr. Sheybani @laurentsheybani.bsky.social and Dr. Jacobs will talk all about HFOs in epilepsy. #HFOnews

Register here: docs.google.com/forms/d/1e-x...

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Laurent Sheybani @laurentsheybani.bsky.social · Mar 23

Disrupting synaptic transmission affects sleep-wake dynamic --> www.cell.com/current-biol...

Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice

Using a mouse model of altered neurotransmission (Vamp2rlss), Guillaumin et al. show that differences typically observed between vigilance states in neural dynamics and spectral signatures can be mark...

www.cell.com

Laurent Sheybani @laurentsheybani.bsky.social · Mar 20

At the MicMac conference in Toulouse, listening to talks on HFOs, and look what comes out in Brain Communications:
doi.org/10.1093/brai...

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Laurent Sheybani @laurentsheybani.bsky.social · Mar 19

Mosaicism in the brain:
doi.org/10.1093/brai...
Complexity should be seen as an opportunity...

Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants

D’Gama et al. studied a prospective patient cohort being evaluated with stereo-EEG electrodes for seizure localization. They identified somatic mosaic vari

doi.org

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Laurent Sheybani @laurentsheybani.bsky.social · Mar 16

Coupling of spindles to slow waves is important for memory, but this is disrupted in people with epilepsy -->

doi.org/10.1111/epi....

Widespread decoupling of spindles and slow waves in temporal lobe epilepsy

Objective Memory impairment is common in people with temporal lobe epilepsy (TLE). Recent studies in healthy subjects showed a positive correlation between sleep spindles coupled to slow waves (SWs)...

doi.org

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Laurent Sheybani @laurentsheybani.bsky.social · Mar 10

Exciting work where we address the mechanisms underlying long held epidemiological associations between epilepsy and sleep.
Thanks to all co-authors: Birgit Frauscher, Christophe Bernard and Matthew C Walker. Thanks to my funding:
@snsf-ch.bsky.social
Guarantors of @brain1878.bsky.social

Nature Reviews Neurology @natrevneurol.nature.com · Mar 10

New online! Mechanistic insights into the interaction between epilepsy and sleep https://bit.ly/4ixu2qu

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Laurent Sheybani @laurentsheybani.bsky.social · Mar 10

Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how?
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...

@natrevneurol.bsky.social

Mechanistic insights into the interaction between epilepsy and sleep - Nature Reviews Neurology

Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associati...

doi.org

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Laurent Sheybani @laurentsheybani.bsky.social · Mar 8

Thalamic activity during wake and sleep in 121 people with epilepsy -->
academic.oup.com/braincomms/a...

Interictal waking and sleep electrophysiological properties of the thalamus in focal epilepsies

Epilepsy is a cortico-subcortical network disorder. By analyzing thalamo-cortical relationships in 121 patients through stereotactic-EEG, Biagioni et al. i

academic.oup.com

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Laurent Sheybani @laurentsheybani.bsky.social · Mar 5

@dgiampiccolo.bsky.social

Brain Communications @braincomms.bsky.social · Mar 5

Matchin et al. report that sentence comprehension relies on distinct networks: working memory maps to dorsal stream damage, while syntax links to ventral stream lesions in post-stroke aphasia. Please read at:https://buff.ly/4ify9Yj @wmatchin @JuliusThor_VPR @Leo_Bonilha @GregoryHickok

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