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Christos Lisgaras @chrislisgaras.bsky.social · 1d

Greatly enjoyed writing this piece for @braincomms.bsky.social!

🔹 "High frequency opportunities for Alzheimer's disease" academic.oup.com/braincomms/a...

This commentary calls for rethinking how we “listen to” and interpret abnormal electrical activity in Alzheimer’s disease and related dementias.

High frequency opportunities for Alzheimer’s disease

This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o

academic.oup.com

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Christos Lisgaras @chrislisgaras.bsky.social · Sep 5

Congratulations Liset!

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Christos Lisgaras @chrislisgaras.bsky.social · Aug 24

Off to beautiful Lisbon to speak the XVIII Workshop on Neurobiology of Epilepsies. Excited about this year’s topic on the resilient brain! Who’s coming?! #HFOnews 🧠 #ILAE @ilae-epilepsy.bsky.social

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Christos Lisgaras @chrislisgaras.bsky.social · Jul 21

Exited to share our new work! We found scalp high frequency oscillations (HFOs) in adults with Down syndrome, before the clinical onset of Alzheimer’s dementia and late onset myoclonic epilepsy.
HFOs may hold the key to earlier diagnosis #HFOnews
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia

INTRODUCTION Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, ...

alz-journals.onlinelibrary.wiley.com

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Christos Lisgaras @chrislisgaras.bsky.social · Jul 8

Interested in how sleep is affected across the Alzheimer’s disease continuum in people with Down syndrome? 💤
Check our new publication with collaborators in Spain out in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Impact of Alzheimer's disease on sleep in adults with Down syndrome

INTRODUCTION Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep ...

alz-journals.onlinelibrary.wiley.com

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Christos Lisgaras @chrislisgaras.bsky.social · Jun 25

Congratulations Martha!!

Christos Lisgaras @chrislisgaras.bsky.social · Jun 23

Likewise! Chat soon 🍻

Christos Lisgaras @chrislisgaras.bsky.social · Jun 23

Attending too!

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Christos Lisgaras @chrislisgaras.bsky.social · Jun 13

Interested in how preclinical studies can help understand EEG patterns? Take a look at our book chapter! With Marco de Curtis and Premysl Jiruska.
link.springer.com/chapter/10.1...
#HFOnews

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Christos Lisgaras @chrislisgaras.bsky.social · Jun 11

#HFOnews! And first outcome publication of the Third International Workshop on High Frequency Oscillations in Epilepsy. 👇👇

Liset M. de la Prida @lmprida.bsky.social · Jun 11

Don’t miss our latest 📝 with @chrislisgaras.bsky.social & Rick Staba on high-frequency oscillations in preclinical 🧠 disease models, with guidelines for recording, detection and analysis. journals.sagepub.com/doi/10.1177/...

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Christos Lisgaras @chrislisgaras.bsky.social · May 16

Off to beautiful Verona for the Spring Hippocampal Research Conference! Who’s coming?! #HFOnews

hippo.euroconferences.org/scientific-p...

Scientific Program

If you determine at the last minute that you cannot travel to Verona, you will have the option of providing a video of your presentation, which will be played in the session in which you are...

hippo.euroconferences.org

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Christos Lisgaras @chrislisgaras.bsky.social · Apr 10

Excited to be speaking about High Frequency Oscillations in Epilepsy and Sleep at the 2nd Annual Sleep Conference in NYC!

Christos Lisgaras @chrislisgaras.bsky.social · Mar 21

Happy World Down Syndrome day! We are advocating and are all inspired by individuals with Down syndrome. #WDSD2025

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Christos Lisgaras @chrislisgaras.bsky.social · Mar 21

Join us next week for an @ilae-epilepsy.bsky.social webinar on High Frequency Oscillations! Dr. Sheybani @laurentsheybani.bsky.social and Dr. Jacobs will talk all about HFOs in epilepsy. #HFOnews

Register here: docs.google.com/forms/d/1e-x...

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Christos Lisgaras @chrislisgaras.bsky.social · Mar 13

A great one by @laurentsheybani.bsky.social - on the reading list!

Laurent Sheybani @laurentsheybani.bsky.social · Mar 10

Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how?
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...

@natrevneurol.bsky.social

Mechanistic insights into the interaction between epilepsy and sleep - Nature Reviews Neurology

Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associati...

doi.org

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Christos Lisgaras @chrislisgaras.bsky.social · Mar 7

Great! hello to the team!!

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Christos Lisgaras @chrislisgaras.bsky.social · Mar 1

www.nia.nih.gov/research/blo...

Beyond amyloid: Targeting a broader range of Alzheimer's disease factors

Learn how Alzheimer's and dementia research targets have evolved.

www.nia.nih.gov

Christos Lisgaras @chrislisgaras.bsky.social · Feb 21

#HFOnews

Epilepsia Journal @epilepsiajournal.bsky.social · Feb 21

Key point: High-density (HD) grid recordings can be used and interpreted for surgical guidance.
doi.org/10.1111/epi....

#epilepsy #ILAE #focalseizures #highfrequencyoscillations #intraoperativetailoring #subduralEEG

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Christos Lisgaras @chrislisgaras.bsky.social · Feb 17

Our #EEG Review was selected as @epilepsiajournal.bsky.social Editor’s Featured Article - give it a read here👇

onlinelibrary.wiley.com/doi/10.1111/...

Epilepsia Journal @epilepsiajournal.bsky.social · Feb 17

New Articles in Epilepsia - February 15, 2025
mailchi.mp/ilae/new-art...

#epilepsy #ILAE

Christos Lisgaras @chrislisgaras.bsky.social · Feb 15

Super excited to see our 2022 animal model study (onlinelibrary.wiley.com/doi/10.1111/...) showing HFOs in Alzheimer’s model systems replicated in humans! @braincomms.bsky.social
The dream of every basic scientist 🤩

Our human study coming very soon :)

#HFOnews

academic.oup.com/braincomms/a...

High‐frequency oscillations (250–500 Hz) in animal models of Alzheimer's disease and two animal models of epilepsy

Objective To test the hypothesis that high-frequency oscillations (HFOs) between 250 and 500 Hz occur in mouse models of Alzheimer's disease (AD) and thus are not unique to epilepsy. Methods Exper.....

onlinelibrary.wiley.com

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Christos Lisgaras @chrislisgaras.bsky.social · Feb 13

Our review discussing the role of EEG in Epilepsy research is now out @epilepsiajournal.bsky.social @ilae-epilepsy.bsky.social

Thanks to all of my co-authors!

onlinelibrary.wiley.com/doi/10.1111/...

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Christos Lisgaras @chrislisgaras.bsky.social · Feb 7

The time has come!

Matteo Carandini @carandinilab.net · Feb 7

Neuropixels and Optogenetics are delighted to announce the birth of

Neuropixels Opto

Combining high-resolution electrophysiology and optogenetics

Today in bioRxiv

960 sites, 28 emitters, 2 colors

By Lakunina, @karolinazsocha.bsky.social, Ladd, et al

www.biorxiv.org/content/10.1...

(1/2)

A Neuropixels Opto probe with 3 blue emitters and 3 red emitters lighting up in succession, with corresponding neural activity in different layers of the cortex.

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Christos Lisgaras @chrislisgaras.bsky.social · Feb 7

Thank you, Laurent!

Christos Lisgaras @chrislisgaras.bsky.social · Feb 6

Looks great can’t wait to dive in!

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Reposted by Christos Lisgaras

Tristan Shuman @tristanshuman.bsky.social · Jan 28

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment.
www.cell.com/cell-reports...

Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman.

In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.

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