Kate LeGrand
@lekate.bsky.social
410 followers 250 following 26 posts
PhD candidate with the LSHTM TB Modelling Group | Geospatial epi, med anthro, and community-based research
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lekate.bsky.social
Reflecting on this year’s #TB #UnionConf2024 and am so inspired by the brilliant minds and groundbreaking research being done to combat this global health threat. Special shoutout to the TB Modelling Group @lshtm.bsky.social 🫁
Reposted by Kate LeGrand
Reposted by Kate LeGrand
kchorton.bsky.social
At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings?

📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n

bit.ly/3V3vXth
The potential impact, cost and cost-effectiveness of tuberculosis interventions - a modelling exercise
Background While a range of interventions exist for tuberculosis prevention, screening, diagnosis, and treatment, their potential population impact and cost-effectiveness are seldom directly compared,...
bit.ly
lekate.bsky.social
📯 New research from @kchorton.bsky.social and colleagues from @lshtm-tbmod.bsky.social!

#TB incidence can rebound after community screening ends, meaning the gains made during a program can be erased in the years that follow. This highlights a major challenge in sustaining impact #EndTB #EpiSky
kchorton.bsky.social
Community screening for #tuberculosis could extend the reach of #TB services, but evidence on its effectiveness is limited.

In our latest preprint, we examine the epidemiological impact of trade-offs in diagnostic algorithm, population coverage, and duration of screening. 1/n

bit.ly/3UK7pFD
Exploring trade-offs in diagnostic algorithm, population coverage, and duration of community screening for tuberculosis
Background Current tuberculosis (TB) prevention and care strategies have failed to reduce disease burden at the pace required to meet global targets. Community screening may enable more rapid declines...
www.medrxiv.org
Reposted by Kate LeGrand
kchorton.bsky.social
New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood.

www.thelancet.com/journals/lan...
The figure shows two graphs, both with age on the x-axis and separate curves for males and females. In the top figure, the y-axis shows prevalence of Mtb immunoreactivity; in the bottom figure, the y-axis shows annual risk of Mtb conversion. In both figures, the curves for males and females diverge from adolescence and remain higher for men than women through adulthood.
Reposted by Kate LeGrand
kchorton.bsky.social
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.

doi.org/10.1016/S221...

@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
Figure 1. Estimated number of trial endpoints in the control group of a prevention-of-disease vaccine trial in a high disease-burden setting showing number of endpoints on the y-axis and time in months on the x-axis. For bacteriologically confirmed symptomatic tuberculosis disease endpoints only, we estimate 69 endpoints, and for combined bacteriologically confirmed asymptomatic and symptomatic tuberculosis disease endpoints, we estimate 151 endpoints. Scenario assumes symptomatic disease incidence before trial screening of 300/100 000 per year and following 10 000 individuals over 3 years. Prevalent symptomatic and asymptomatic tuberculosis disease are screened out in month 0 and are not trial endpoints. Active screening occurs every 6 months for both scenarios and participants self-presenting with symptoms suggestive of tuberculosis disease would also be investigated.
Reposted by Kate LeGrand
hannahritchie.bsky.social
Tuberculosis still kills around 1.3 million people every year.

It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?

Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
Reposted by Kate LeGrand
Reposted by Kate LeGrand
johngreensbluesky.bsky.social
The chest x-ray use pioneered by Alan Hart continues to be extremely important in screening for tuberculosis. Although no one accomplishes anything in isolation, I'd argue that Hart has helped saved MILLIONS of lives because chest x-rays have been so essential in driving down rates of TB globally.
erininthemorning.com
Remembering Dr. Alan Hart for Pride, trans man from the early 1900s. He revolutionized the detection of tuberculosis, saved thousands of lives, and died using his name, as the man he always was meant to be.

We have always been here.
Reposted by Kate LeGrand
reinhouben.bsky.social
Amid all the bad news in Global Health, perhaps some good news? A first analysis on the risk of false positive diagnoses in community-screening for tuberculosis using Xpert shows our clinic-based data is likely (very) wrong and overestimates false positives by >80%: tinyurl.com/yfecute9.
lekate.bsky.social
Come work with us at @lshtm-tbmod.bsky.social!
🏁Application closes Friday
lshtm-tbmod.bsky.social
Are you interested in #TB and have experience in #modelling infectious diseases?

Come join us in the TB Modelling Group at #LSHTM!

We're advertising for a 1 year Research Fellow position, with a closing date of 30 May 2025 👉 jobs.lshtm.ac.uk/vacancy.aspx...
Job Opportunity at LSHTM: Research Fellow
The London School of Hygiene & Tropical Medicine (LSHTM) is a world-leading centre for research and postgraduate education in public and global health. Our mission is to is to improve health and healt...
jobs.lshtm.ac.uk
lekate.bsky.social
New preprint out from @raclark18.bsky.social, @kchorton.bsky.social, and colleagues from @lshtm-tbmod.bsky.social. The sudden withdrawal of international aid risks reversing years of hard-won gains. Beyond USAID, potential funding cuts via The Global Fund could add nearly 1M #TB deaths #EpiSky
Reposted by Kate LeGrand
kchorton.bsky.social
Modelling projects the devastating impacts of US funding cuts, including our estimates of #TB incidence and deaths @lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
altcdc.altgov.info
A Lancet preprint estimates that if US funding is cut and not replaced, from 2025-2040 there will be 15.2 mil add'l AIDS deaths, 2.2 mil add'l TB deaths, 7.9 mil add'l child deaths from other causes, and 40-55 mil add'l unplanned pregnancies.

@altusaid.altgov.info

papers.ssrn.com/sol3/papers....
A line graph of estimated AIDS-related deaths from 2025 through 2040 in 55 PEPFAR-supported countries. The Y axis is estimated number of deaths and ranges from 200,000 to 2 million. The X axis is years and ranges from 2010 to 2040. There is a black line labeled “historical trend” from 2010 to 2025 showing a decrease in deaths from 1.2 million to ~420,000. Then in 2025 the black line splits into three scenarios: 1) a dashed green line showing deaths if USAID were to increase, 2) a dashed blue line showing deaths if USAID remained at 2024 levels, and 3) a dashed red line showing deaths if USAID stopped and was not replaced. In scenario 1 (funding increased) deaths continue to decrease from ~420,000 to 200,000. In scenario 2 (funding stays the same) deaths stay the same at 420,000. In scenario 3 (funding cut and not replaced) deaths increase from ~420,000 to 1.7 million.
Reposted by Kate LeGrand
lancetmicrobe.bsky.social
New review article

Integrating genomic and spatial analyses to describe #tuberculosis transmission: a scoping review

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #TB #OpenAccess #OA
Reposted by Kate LeGrand
alexandra-richards.bsky.social
Great to be able to finally get this work out, closing out my time with @lshtm-tbmod.bsky.social
petermacp.bsky.social
New preprint led by @alexandra-richards.bsky.social & @kchorton.bsky.social from @lightontb.bsky.social

Eliminating men’s excess risks for #TB & improving access to treatment to comparable rates to women could have major gains for men, women & children.

www.medrxiv.org/content/10.1...
Reposted by Kate LeGrand
cfmcquaid.bsky.social
In 2024, 68 million people were internally displaced by humanitarian crises, & are at increased risk of TB, the world's biggest infectious disease killer. We urgently need estimates to identify the scale of this problem & drive our response. We provide initial numbers here gh.bmj.com/content/10/3...
Thinking fast and slow: the urgency of crisis response must not lead us to overlook chronic needs such as tuberculosis
The number of people facing displacement due to humanitarian crises worldwide is increasing rapidly and is likely to continue. An average 10% year-on-year increase in the last 5 years resulted in 68.3...
gh.bmj.com
lekate.bsky.social
It’s here! Ready to be both devastated and inspired by John Green’s "Everything is #Tuberculosis." Let's educate ourselves and demand action, understanding that knowledge is the first step towards dismantling injustice.
@johngreensbluesky.bsky.social #TBSky #EndTB #EpiSky
lekate.bsky.social
A new analysis from my friend, Khai Tram, and his colleagues, estimates over 100,000 excess HIV-related deaths in the next year due to the current 90-day pause in PEPFAR funding. The actions of this administration are nothing short of reprehensible. Call your representatives!! #EpiSky #IDSky #MedSky
jirairratevosian.bsky.social
New: Our analysis indicates that the Trump administration's proposed 90-day policy review would result in at least 100,000 lives lost over the next year. onlinelibrary.wiley.com/doi/epdf/10....
Reposted by Kate LeGrand
cfmcquaid.bsky.social
Climate change is likely to exacerbate determinants which drive TB, the world’s leading infectious disease killer. Commissioned by WHO, we developed an analytical framework outlining potential causal relationships between climate change and TB:
medrxiv.org/cgi/content/...
@lshtm.bsky.social @who.int
Climate change and tuberculosis: an analytical framework
Climate change is likely to exacerbate a range of determinants which drive tuberculosis, the world's leading infectious disease killer. However, tuberculosis is often neglected in wider climate health...
medrxiv.org