Lightnews — Scholar-powered news

Reposted by Laura Gutiérrez-Miranda

Jane Goodall Institute of Canada @janegoodallcan.bsky.social · 7d

Dr. Jane made an indelible mark on our understanding of chimpanzees and other species, and also of humankind and the environments we all share.

She inspired curiosity, hope, and compassion in countless people, and paved the way for many others.

#ThankYouJane #RememberingJane

Photo: Marko Zlousic

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Reposted by Laura Gutiérrez-Miranda

Journal of Experimental Medicine @jem.org · Aug 21

Bassi et al. @karinayaniv.bsky.social @weizmanninstitute.bsky.social use #zebrafish to help identify new treatments for a severe lymphatic malformation. rupress.org/jem/article/...

#CardiovascularBiology #HumanDiseaseGenetics

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Reposted by Laura Gutiérrez-Miranda

Kevin Thiessen, PhD @kevinthiessen.bsky.social · May 18

My Bioinformatics Bootcamp turned blog! Enjoy this collection of free #zebrafish resources, now posted on @the-node.bsky.social. While not comprehensive, it gives an assortment of cools tools available to researchers. Feedback would be appreciated! thenode.biologists.com/bioinformati...

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · May 2

And just like that we get another #zebrafish surprise !
@pina85.bsky.social work introduces the Inferior Vena Cava vascular remodelling in zebrafish 🦓🐟
Congratulations to all the team for this beautiful story 👏🏻🍾

Giuseppina lambiase @pina85.bsky.social · May 2

I'm thrilled to announce that my #phd work is now out in #biorxiv. Check it out here! I will be happy to have your feedback! www.biorxiv.org/content/10.1... Thank you to @karinayaniv.bsky.social, Rudra N. Das for the menthorship and all authors.

In this work we discovered that during metamophosis there is a remodeling of Zebrafish Cardinal Vein followed by a replacement with the Inferior Vena Cava. This process mirrors the Human Inferior Vena Cava development, demostrating a conserved mechanism through the mammals. In this panel all the steps of Inferior Vena Cava formation (blood vascular marker, kdrl in green).

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Apr 25

And that is a wrap! Great success of the first European #Lymphatic Symposium
Next one: Budapest 2027

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Apr 4

Axillary lymphoid organ in #zebrafish
🤩
rupress.org/jem/article/...

The axillary lymphoid organ is an external, experimentally accessible immune organ in the zebrafish

This work describes a previously uncharacterized external, experimentally accessible secondary lymphoid organ in the zebrafish located above the pectoral f

rupress.org

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Mar 4

Do not miss it! ⬇️
@ivanbassi.bsky.social will present his latest project 🐟 #zebrafish

EVBO @evborg.bsky.social · Feb 25

#EVBOSeminarSeries Moderated by Thomas Juan. Speakers: @miguel-torres-1963.bsky.social and @ivanbassi.bsky.social.
⏰When: Wednesday, 5th March 2025, EU time (2PM UK). Place: online.
See you there! For registration www.evbo.org

European Vascular Biology Organisation - Advancing human health by understanding the function and pathology of blood and lymphatic vessels

Advancing human health by understanding the function and pathology of blood and lymphatic vessels

www.evbo.org

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Reposted by Laura Gutiérrez-Miranda

Kaska Koltowska @lymphaticslab.bsky.social · Feb 10

🤩 Excited to share our protocol for computationally averaging confocal images of zebrafish lymphatic vessels to identify phenotypes! 🐟🔬 Check it out in Star Protocols 👉 star-protocols.cell.com/protocols/4030

#Zebrafish #Microscopy #StarProtocols

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Feb 6

Not sure exactly what is going on but I have also received this message today at times where traffic should be rather low 😅
So just to be on the safe side here...Does anybody know if there is a mirror page or alternatives in case one of these days NCBI page is gone? 💨

Matias @kaplan.bio · Feb 6

How long does PubMed have? How long will BLAST be up? Genome browser? We have the funding to keep these tools up, we have the expertise, we have the people.

Loss of these tools would cost billions to replace by the private sector and academia. Inefficient destruction with no upside

PubMed site with “Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.”

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Jan 28

Generation of functional oocytes from male mice🤯
www.nature.com/articles/s41...

Generation of functional oocytes from male mice in vitro - Nature

Mouse induced pluripotent stem cells derived from differentiated fibroblasts could be converted from male (XY) to female (XX), resulting in cells that could form oocytes and give rise to offspring aft...

www.nature.com

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Reposted by Laura Gutiérrez-Miranda

Zebrafish Rock! @zebrafishrock.bsky.social · Jan 27

Useful new tool, for those finterested!

Seth Blackshaw @sethblackshaw.bsky.social · Jan 27

Introducing MetaLigand, our latest collaboration with the Qian group, a database for predicting non-peptide ligand mediated cell-cell signaling.

www.biorxiv.org/content/10.1...

MetaLigand: A database for predicting non-peptide ligand mediated cell-cell communication

Non-peptide ligands (NPLs), including lipids, amino acids, carbohydrates, and non-peptide neurotransmitters and hormones, play a critical role in ligand-receptor-mediated cell-cell communication, driv...

www.biorxiv.org

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Jan 13

Same here! We can only wait and cross fingers for Rita Fior's lab and all the team at Champalimaud 🤞🏻

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Jan 13

The first oncology clinical trial using #zebrafish avatars will start this month in Portugal. It is definitely not an easy task. But if it works, it will be a great predictive tool 💪🏻 Good luck!
www.science.org/content/arti...

Fish implanted with tumor cells could help oncologists quickly personalize cancer treatments

The first clinical trial of zebrafish embryos acting as cancer “avatars” will start soon

www.science.org

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Jan 11

www.nature.com/articles/s41...

Repurposing of a gill gene regulatory program for outer ear evolution - Nature

Nature - Repurposing of a gill gene regulatory program for outer ear evolution

www.nature.com

Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Jan 4

www.nature.com/articles/s44...

Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research

Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...

www.nature.com

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Jan 2

The only #resolution I want for the new year 😅
www.biorxiv.org/content/10.1...
#microscopy

Deep-Tissue Spatial Omics: Imaging Whole-Embryo Transcriptomics and Subcellular Structures at High Spatial Resolution

The inherent limitations of fluorescence microscopy, notably the restricted number of color channels, have long constrained comprehensive spatial analysis in biological specimens. Here, we introduce c...

www.biorxiv.org

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Dec 26

I remember doing the ant maze as a lab activity few years ago...and with no communication among the members allowed...it was not so easy 😅
www.pnas.org/doi/10.1073/...

Comparing cooperative geometric puzzle solving in ants versus humans | PNAS

Biological ensembles use collective intelligence to tackle challenges together, but suboptimal coordination can undermine the effectiveness of grou...

www.pnas.org

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Reposted by Laura Gutiérrez-Miranda

Journal of Cell Science @jcellsci.bsky.social · Dec 16

Aanandita Kothurkar, @colinchulab.bsky.social, Ryan MacDonald and colleagues @ucleye.bsky.social apply IBEX to simultaneously identify all the major retinal cell types.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

Figure showing that IBEX can be used to simultaneously label all major retinal types in zebrafish embryos, including confocal images and schematics indicating the labelled cell types. The confocal images show zebrafish retinas labelled with DAPI and 11 different markers: Ribeye-A (dark blue), carbonic anhydrase (CA1, purple), glutamine synthetase (GS, red), PKC-β (green), Zrf-1 (cyan), HuC/D (orange), GFP transgene (yellow), calbindin (CalB, magenta), peripherin-2 (PRPH2, light blue), GNAT2 (orange) and RLBP1 (pink).

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Reposted by Laura Gutiérrez-Miranda

bioRxivpreprint @biorxivpreprint.bsky.social · Dec 6

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins https://www.biorxiv.org/content/10.1101/2024.12.04.626907v1

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Reposted by Laura Gutiérrez-Miranda

Zebrafish Rock! @zebrafishrock.bsky.social · Dec 2

Help support ZFIN and other MODs by signing this open letter 🙏 🧪

Alliance of Genome Resources @alliancegenome.bsky.social · Nov 15

The Global Biodata Coalition has an open letter campaign to show support for sustainable funding for biodata resources. Please take a minute to read and decide if you want to sign globalbiodata.org/open-letter-...
#biocuration #bioinformatics

OPEN LETTER CAMPAIGN - Global Biodata Coalition

Careers at the Global Biodata Coalition.

globalbiodata.org

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Reposted by Laura Gutiérrez-Miranda

Development @dev-journal.bsky.social · Nov 30

Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration

Read this Research Article by Sierra Duca, Yu Xia, Michael R. M. Harrison, Jingli Cao and colleagues:
https://buff.ly/49hhwIf

Figure 1 (A) Larval expression of vegfc:EGFP (green) and kdrl:DsRed (magenta) lines in a 2 dpf live fish. Scale bar: 200 µm. (B) Confocal images showing vegfc:EGFP (green) and kdrl:DsRed (magenta) expression in the trunk at 2 dpf. A single-channel image of vegfc:EGFP expression is shown in grayscale on the right. Scale bar: 100 µm. (C,D) Whole-mount images (maximum projections of z-stacks) of the ventricular surface showing expression of vegfc:EGFP (green) and flt1:tdTomato (magenta) at 5 wpf (C) or 8-9 wpf (D). Single-channel images of vegfc:EGFP expression are shown in grayscale on the right. The framed regions are enlarged beneath. The arrows indicate EGFP+tdTpmato+ arteries. Scale bars: 100 µm.

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Nov 26

Amazing work really, congratulations!!

Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Nov 26

New study on clonal fate during mouse #embryogenesis using in vivo lineage tracing+ deep learning 🤯👏🏻👏🏻

Igor Adameyko @adameykolab.bsky.social · Nov 25

(1) How can we build complex structures from a limited set of progenitors and cell types? In our new preprint, we describe patterns of cell fate decisions during early development and (in some cases) identify molecular correlates of different behaviors.

www.biorxiv.org/content/10.1...

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases

Embryogenesis is commonly viewed through a tree model of cell differentiation, which does not adequately represent the spatiotemporal modulation of cell multipotency underlying morphogenesis. Here we ...

www.biorxiv.org

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Reposted by Laura Gutiérrez-Miranda

Vishal Mohanakrishnan @vishalmkrishnan.bsky.social · Nov 19

Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". 🦴🔬😍

Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.

www.nature.com/articles/s41...

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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · Nov 22

I would like to be added please 🙋🏻‍♀️

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