Liron Bar-Peled
@liron1bar-peled.bsky.social
780 followers 200 following 19 posts
Associate Professor at MGH Krantz Center for Cancer Research and Harvard Medical School Department of Medicine. Intersection of signaling, metabolism and chemical biology.
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liron1bar-peled.bsky.social
Congratulations Ed and team!
Reposted by Liron Bar-Peled
ubellackerlab.bsky.social
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
liron1bar-peled.bsky.social
Congrats Walter and Ralph!!!
liron1bar-peled.bsky.social
Congratulations Yogesh! Awesome work
liron1bar-peled.bsky.social
Congratulations Judy!!! So well deserved
Reposted by Liron Bar-Peled
Reposted by Liron Bar-Peled
themarkfdn.bsky.social
Last night, past Mark Foundation Emerging Leader Award winners gathered with this year’s recipients, @marasherman.bsky.social , @liron1bar-peled.bsky.social, Kai Kessenbrock, Ansu Satpathy, and Dan Wahl, to celebrate seven years of this transformational program. #MarkSymposium
liron1bar-peled.bsky.social
Too kind! Hope all is well with you :)
liron1bar-peled.bsky.social
Thank you to Florian Ullrich for shepherding this along and useful insights along the way. Finally, none of this work is done in isolation and want to shout again to all the members of our lab (barpeledlab.org)!!!!
liron1bar-peled.bsky.social
This would not have been possible without funding from NCI, @theaacr, MaryKay, @ludwigcancer, @targetcancer, Vfoundation, @pewtrusts and ALKLungCancer.
Bar-Peled Lab
barpeledlab.org
liron1bar-peled.bsky.social
which we find is a key lever within cells to control ROS levels. Really great collaboration with @brainliau and other wonderful colleagues MGHCancerCenter including Chris Ott.
Bar-Peled Lab
barpeledlab.org
liron1bar-peled.bsky.social
chemoresistance. Check it out here: www.nature.com/articles/s41586-025-08756-y. Using base editing and computational screens, we uncovered how changes in cytosolic redox converge onto VPS35 to regulate its localization, alter plasma membrane protein content and influence mitochondrial translation,
Oxidation of retromer complex controls mitochondrial translation - Nature
Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...
www.nature.com
liron1bar-peled.bsky.social
I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and
Oxidation of retromer complex controls mitochondrial translation - Nature
Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...
www.nature.com
Reposted by Liron Bar-Peled
brianliau.bsky.social
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
liron1bar-peled.bsky.social
Congratulations Brian, this is really an awesome study!!!
Reposted by Liron Bar-Peled
srviswanathan.bsky.social
Excited to share our new study on translocation RCC (tRCC) in collaboration with @liron1bar-peled.bsky.social. We reveal how the TFE3 fusion drives a key oxidative phosphorylation (OXPHOS) metabolic program in this rare kidney cancer. trebuchet.public.springernature.app/get_content/... 1/
liron1bar-peled.bsky.social
Very grateful to have a role in this and work with a great collaborator Srini!!!