littleneuro.bsky.social
Simon Little
@littleneuro.bsky.social
160 followers 170 following 6 posts
Neurologist & Neuroscientist interested in Brain Stimulation, Movement, Mood, Motivation, Sleep, Self Regulation, Psychology and Parenting
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littleneuro.bsky.social
Simon Little @littleneuro.bsky.social · Jun 27
Grateful to the big team and collaborators including Jeffrey Herron, Ph.D. and @gallantlab.org who helped make this possible as well as other members of littlelab.ucsf.edu
Little Lab, UCSF Neurology
littlelab.ucsf.edu
littleneuro.bsky.social
Simon Little @littleneuro.bsky.social · Jun 27
This was fully programmed using ML, remotely in patients own homes, addressing the challenges of increasing DBS programming complexity.
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littleneuro.bsky.social
Simon Little @littleneuro.bsky.social · Jun 27
Happy to share our latest study led by Tanner Dixon and our team @ucsfhealth.bsky.social and @neurosurgucsf.bsky.social out today in Nature BME! Movement Responsive, AI programmed, BCI-aDBS improves naturalistic movements and reduces excessive movements at rest in PD.
www.nature.com/articles/s41...
Movement-responsive deep brain stimulation for Parkinson’s disease using a remotely optimized neural decoder - Nature Biomedical Engineering
An adaptive deep brain stimulation algorithm delivers targeted stimulation increases during movement using brain motor signals.
www.nature.com
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Reposted by Simon Little
gershbrain.bsky.social
Sam Gershman @gershbrain.bsky.social · Mar 31
I'd like to see a revival of panache and artistry in scientific prose style. Since we have to read so many papers, they should be fun and beautiful. I would also argue that this serves the goal of communication: readers will be more likely to remember a striking phrase or image.
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littleneuro.bsky.social
Simon Little @littleneuro.bsky.social · Jan 21
Happy to be launching this Special Edition in NPJ Parkinson’s on all things sleep and PD related
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Reposted by Simon Little
claeneuro.bsky.social
CLaE @claeneuro.bsky.social · Dec 21
Nature

Psilocybin desynchronizes the human brain
www.nature.com/articles/s41...
Psilocybin desynchronizes the human brain - Nature
Healthy adults were tracked before, during and after high doses of psilocybin and methylphenidate to assess how psychedelics can change human brain networks, and psilocybin was found to massively disr...
www.nature.com
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Reposted by Simon Little
drrickadams.bsky.social
Prof Rick Adams @drrickadams.bsky.social · Dec 20
This will build on amazing recent work by @melgaby.bsky.social and others, looking at how planning algorithms are encoded in prefrontal cortex circuits: bsky.app/profile/melg...
melgaby.bsky.social
Mohamady El-Gaby @melgaby.bsky.social · Nov 25
A bit late to the Bluesky party but here’s our work showing a coordinate system for behavioural space, and an algorithm for computing behavioural sequences in the mFC: www.nature.com/articles/s41...
A cellular basis for mapping behavioural structure - Nature
Mice generalize complex task structures by using neurons in the medial frontal cortex that encode progress to task goals and embed behavioural sequences.
www.nature.com
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littleneuro.bsky.social
Simon Little @littleneuro.bsky.social · Dec 20
Great job Andy!!
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littleneuro.bsky.social
Simon Little @littleneuro.bsky.social · Dec 19
Jimmy- you are the best and thoroughly deserved!!!
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Reposted by Simon Little
natureportfolio.nature.com
Nature Portfolio @natureportfolio.nature.com · Dec 2
A study in Nature Medicine finds that deep brain stimulation of a region called the lateral hypothalamus improves walking and promotes recovery in humans and rodents with spinal cord injury. https://go.nature.com/3Vlosyl 🧪
This is figure 6, which shows that DBSLH mediates long-term improvements in walking in humans with SCI.
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