Animal survival in fluctuating environments depend on the ability to modulate their developmental pace in response to nutrient availability, a phenomenon known as developmental plasticity. In Drosophi...

Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

Gut-to-brain communication via glial cytokine signaling links intestinal oxidative stress to altered sleep patterns, highlighting how gut inflammation can influence brain function and restorative slee...

Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we id…

Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes critical for physiological homeostasis and organismal ageing. While mTORC1 preferenti...

Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Dr...

Occupying the interface between host and environment, host-associated microbes play essential roles in interactions with pathogens and influence disease progression (1–4). Considering that most entry ...

Juvenile growth is an adaptive trait since chronic undernutrition leads to reduced growth rate and delayed maturation. Using Drosophila and mouse gnotobiotic models, we previously established the evol...