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LPJ Lab - Neuroimmunometabolism

@lpjlab.org

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Welcome to Luca Peruzzotti-Jametti's lab @University of Cambridge! We're dedicated to investigating how cell #metabolism shapes #brain - #immune interactions to pioneer new therapies for #MultipleSclerosis and other CNS disorders. https://www.LPJLab.org

www.LPJLab.org

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Sep 4

Excited to share that I was a guest on MS-Perspektive - The #MultipleSclerosis #Podcast with Nele von Horsten! 🎧

We had a great chat about the latest research in MS and how we're working to find new treatments. 💪

Listen to the full episode here 👇
ms-perspektive.com/129-luca-per...

Hope for Myelin Repair: Stem Cells & Progressive MS

Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

ms-perspektive.com

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · 4d

New Nature Metabolism review breaks down the history, role, and therapeutic promise of itaconate. Learn how this metabolite exerts potent anti-inflammatory effects—a crucial mechanism for future drug development!
#Immunometabolism #Inflammation
www.nature.com/articles/s42...

Metabolic Messengers: itaconate

McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.

www.nature.com

LPJ Lab - Neuroimmunometabolism @lpjlab.org · 4d

Fascinating read on #brain 🧠 tumor #immunology! Primary brain tumors vs metastases have fundamentally different immune microenvironments.
This is why secondaries often show a better response to #immunotherapy. share.google/RJdXIc02PCyH...

share.google

Reposted by LPJ Lab - Neuroimmunometabolism

Michael Platten, MD @michael-platten.bsky.social · 4d

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

The immunology of brain tumors

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

www.science.org

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · 15d

New preprint: #Microglia don't just clear debris - they undergo a massive metabolic overhaul after phagocytosis, including adaptive mitochondrial changes, which may make them pro-regenerative! 🥳🧠💪
#Neuroscience #Mitochondria #Metabolism #BioRxiv

www.biorxiv.org/content/10.1...

Metabolic and transcriptional adaptations to phagocytosis sustain microglia functionality and regenerative properties

Phagocytosis of apoptotic cells, or efferocytosis, is a tightly regulated process that ensures tissue homeostasis and prevents mounting inflammatory responses. In the brain parenchyma, it is executed ...

www.biorxiv.org

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · 21d

Use the form on our website! www.LPJLab.org

LPJLab

www.lpjlab.org

LPJ Lab - Neuroimmunometabolism @lpjlab.org · 22d

#PhD position available!

Our collaborator Roberta Magliozzi is looking for a motivated student to map the meningeal immune landscape in #MultipleSclerosis.
This is a great opportunity for anyone interested in neuroimmunology! 🧠

Please SHARE and APPLY here:
www.imperial.ac.uk/brain-scienc...

Funding

Funding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have obtaine...

www.imperial.ac.uk

LPJ Lab - Neuroimmunometabolism @lpjlab.org · 24d

Thank you, Stuart!
Glad you were able to attend. CNS inflammation is such an important and evolving area of neuroscience. I think it's a field with immense potential for new discoveries and tangible patient benefits.

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Reposted by LPJ Lab - Neuroimmunometabolism

Cambridge Neuroscience @camneuro.bsky.social · 27d

Session Six featured fantastic talks by Prof. Vendeuscolo from the Dept. of Chemistry @cam.ac.uk, Prof. Peruzzotti-Jametti from the Dept. of Clinical Neurosciences @cam.ac.uk, and the Andrew Huxley Plenary Lecture by our special guest Prof. Studer from the Sloan Kettering Cancer Center, NY
#CNS2025

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · 28d

Human myelinated brain organoids with integrated #microglia as a model for #myelin repair and remyelinating therapies | Science Translational Medicine
www.science.org/doi/10.1126/...

Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies

Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

www.science.org

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Reposted by LPJ Lab - Neuroimmunometabolism

Gregory MS @gregory-ms.com · 28d

An interview with Dr. Luca Peruzzotti Jametti on the topic of #Myelin repair.

ms-perspektive.de/en/129-luca-...

#MSchat #MultipleSclerosis #Neurology #StemCells @pluchinolab.bsky.social @restorems.bsky.social @lpjlab.org

Hope for Myelin Repair: Stem Cells & Progressive MS

Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

ms-perspektive.de

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · 29d

Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience!

www.cell.com/cell/fulltex...

Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience

A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...

www.cell.com

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Sep 4

Hope for Myelin Repair: Stem Cells & Progressive MS

Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

ms-perspektive.com

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Reposted by LPJ Lab - Neuroimmunometabolism

Cytosurge AG @cytosurge.bsky.social · Aug 29

www.nature.com/articles/s43... reproduced in vitro thanks to #FluidFM

MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation - Nature Cancer

Cangkrama et al. show that tumor cells from various cancer types use the mitochondrial trafficking protein MIRO2 and nanotubes to transfer mitochondria into surrounding fibroblasts, thereby inducing c...

www.nature.com

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Reposted by LPJ Lab - Neuroimmunometabolism

Nature Metabolism @natmetabolism.nature.com · Aug 27

PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis)

An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application

https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab

Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism

Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.

bit.ly

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Aug 27

Absolutely! And I was happy to see that we share the same opinions! 😁

LPJ Lab - Neuroimmunometabolism @lpjlab.org · Aug 27

Beyond understanding the #brain, our goal is to heal it!
www.lpjlab.org/news-1/8dgsijj0s02907evez1bmai1fht6pa

Join us on September 10-11 at the 8th #Cambridge #Neuroscience Symposium to explore the latest breakthroughs that are poised to transform #patient care!

Register here: tinyurl.com/27rzs5ku

LPJ Lab - Neuroimmunometabolism @lpjlab.org · Aug 27

The debate on intercellular mitochondrial transfer is heating up! In this new Viewpoint, eminent scientists in the field of mitochondrial biology, including our friend @rubenqc-lab.bsky.social, share their views on the topic.
Dive in and let us know what you think!

www.nature.com/articles/s42...

Mitochondrial transfer - Nature Metabolism

Intercellular mitochondrial transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticis...

www.nature.com

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Aug 26

Cool event alert! 🧠
The next European Microglial Webinar is happening on Tuesday, 02/09 at 5pm CEST / 3pm GMT.
Michael Dolan will be speaking on "Formation and Function of Microglial States in Remyelination."
Zoom Link: unil.zoom.us/j/93018596158
#Microglia #Neuroscience

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Reposted by LPJ Lab - Neuroimmunometabolism

RyanLab_TCD @ryanlab.bsky.social · Jul 25

The source of dietary fat influences anti-tumour immunity in obese mice #immunometabolism
Great work from @lydialynch.bsky.social lab and colleagues
www.nature.com/articles/s42...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

www.nature.com

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Jul 22

It's a fun way to release some steam! 💪

LPJ Lab - Neuroimmunometabolism @lpjlab.org · Jul 22

What a night!
Our lab traded pipettes for axes, and let's just say we honed our missing skills with expert precision! 😉
It was an absolute blast seeing everyone de-stress and have a laugh, no matter where the axes landed 🪓🎯
Huge thanks to everyone! 👏
#Neuroscience #AxeThrowing #TeamBuilding

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Jul 9

A super cool #single-cell spatial transcriptomic mouse #brain atlas is out! 🐭🧠🔬
Unveiling cell types, #gene expression, & TF dynamics across the whole brain!
Awesome! ✨
#neuroskyence #neuroscience #compneurosky

www.cell.com/neuron/fullt...

Single-cell spatial transcriptomic atlas of the whole mouse brain

Han et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas with over 4 million spatially resolved cells and 29,655 genes. Their findings include region- enriched cell clusters a...

www.cell.com

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Jul 9

Thrilled to share our latest paper showing that the transplantation of directly induced neural #StemCells enhances #remyelination of chronic demyelinating lesions!
💉🧠=💪
A great team effort with @pluchinolab.bsky.social and all our collaborators! #MultipleSclerosis

academic.oup.com/brain/advanc...

Remyelination of chronic demyelinated lesions with directly induced neural stem cells

Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts. They show that i

academic.oup.com

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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Jul 9

We're very excited about the potential implications of this work! It was a significant team effort with @pluchinolab.bsky.social

Reposted by LPJ Lab - Neuroimmunometabolism

Clinical Neurosciences, Cambridge @camneurodept.bsky.social · Jul 7

An @cam.ac.uk study published in Brain shows stem cell grafts can restore myelin in #MS lesions in mice. This holds promise for chronic demyelinating disorders & progressive multiple sclerosis.

Congrats to @lpjlab.org @pluchinolab.bsky.social

The paper: academic.oup.com/brain/advanc...

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