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François Rousset @francoisrousset.bsky.social · Sep 4

Super excited to receive the ERC starting grant to explore what phage-bacteria interactions can teach us on host-pathogen conflicts 🤩 I'm immensely grateful to my wonderful team and to present and past mentors 🙏

European Research Council (ERC) @erc.europa.eu · Sep 4

📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope

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Aude Bernheim @audeber.bsky.social · Jul 24

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

www.science.org

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Arinjay Banerjee @banerjeelab.ca · Jul 1

🚨Our new study out today in Nature Communications. Bats can asymptomatically host multiple viruses while remaining apparently healthy. Here we identify how interferon-mediated responses protect bats and identify molecular adaptations in GBP1. #LZCI
Link: www.nature.com/articles/s41...

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity - Nature Communications

Bats harbor diverse viruses but it’s less clear how they tolerate infection. Here, by characterizing innate immune responses in bat cells the authors show that IFN-beta signaling resists antagonistic ...

www.nature.com

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Lucie Etienne @lucievirevolte.bsky.social · Mar 8

Thank you, Julie

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Lucie Etienne @lucievirevolte.bsky.social · Mar 7

#standupforscience in Lyon!
For science in France and in the world.
In solidarity to our American colleagues.

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Reposted by Lucie Etienne

Stand Up For Science France @standupforscifr.bsky.social · Mar 6

Stand up for science Lyon / Grand Est :

*Lyon*
16h00 – Rassemblement place des Terreaux.

*Nancy*
10h00 – Débats. Amphithéâtre de la présidence Léopold, 34 cours Léopold, Nancy.
12-30-13h30 – ronde des obstiné·e·s.
Place Stanislas, Nancy.

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Reposted by Lucie Etienne

IRIM @irim-life.bsky.social · Nov 12

We're hiring a Group Leader in Infection Biology! 🧬
Apply now to join us at the IRIM in Montpellier, and lead cutting-edge research in pathogen virulence, host-pathogen interactions or drug resistance, and shape the future of infection biology! 🦠🧫
Please RT (and follow us!)
🗓️ Deadline: Feb. 28, 2025

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CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · Feb 18

#TalentsCNRS 🥉 | Découvrez la vidéo de Lucie Etienne, chercheuse au Centre international de recherche en infectiologie et lauréate de la médaille de bronze du @cnrs.fr en 2024 !

@cnrsbiologie.bsky.social @lucievirevolte.bsky.social @ensdelyon.bsky.social @inserm.fr

www.youtube.com/watch?v=jE8b...

Lucie Etienne : décryptage des épidémies virales et des défenses immunitaires l TalentsCNRS

YouTube video by CNRS

www.youtube.com

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Reposted by Lucie Etienne

Arinjay Banerjee @banerjeelab.ca · Feb 20

Thorough and nice study from @lucievirevolte.bsky.social and colleagues. Bat GBP5.

David Enard @denard.bsky.social · Feb 18

New paper with @lucievirevolte.bsky.social and @psudmant.bsky.social, led by Lucie Etienne and Amandine Le Corf.
The sub-cellular localization of important innate antiviral factor GBP5 has evolved multiple times during bat evolution, with consequences for activity.
www.biorxiv.org/content/10.1...

www.biorxiv.org

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Lucie Etienne @lucievirevolte.bsky.social · Feb 19

Thank you, Jia ! 🌻

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David Enard @denard.bsky.social · Feb 18

New paper with @lucievirevolte.bsky.social and @psudmant.bsky.social, led by Lucie Etienne and Amandine Le Corf.
The sub-cellular localization of important innate antiviral factor GBP5 has evolved multiple times during bat evolution, with consequences for activity.
www.biorxiv.org/content/10.1...

www.biorxiv.org

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Lucie Etienne @lucievirevolte.bsky.social · Feb 17

Through this work, we hope to enlighten adaptations in bat innate immunity and provide insights in the functions of GBP5

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Lucie Etienne @lucievirevolte.bsky.social · Feb 17

Thank you to all coauthors for their contribution.

Also a big shout out to Sarah Maesen for her contribution, co-mentored with Carine Rey at #BIBS during her Master internship @ciri-lyon.bsky.social

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Lucie Etienne @lucievirevolte.bsky.social · Feb 17

Such a blast to collaborate w. Enard & Sudmant Labs: #IRP #IRC @cnrsbiologie.bsky.social @cnrswashington.bsky.social @ucberkeleyofficial.bsky.social @uarizona.bsky.social
partnership!
Special thanks to Elise Lauterbur @lauterbur.bsky.social & Manny Vazquez⭐
@denard.bsky.social @psudmant.bsky.social

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Lucie Etienne @lucievirevolte.bsky.social · Feb 17

Terrific interdisciplinary and international work by Amandine Le Corf @ciri-lyon.bsky.social @cnrs-rhoneauvergne.bsky.social @ensdelyon.bsky.social , from phylogenomics to molecular and cellular virology! 👏

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Lucie Etienne @lucievirevolte.bsky.social · Feb 17

👀Our latest work, led by Amandine Le Corf fantastic PhD student alumni @biorxivpreprint.bsky.social . Great collab @denard.bsky.social @psudmant.bsky.social

Genomic and functional #adaptations in #GBP5 highlight specificities of #bat antiviral innate #immunity 🦇🦠

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Frederic Delsuc @freddelsuc.bsky.social · Feb 7

New @erc.europa.eu funded #ConvergeAnt paper on phylogenetics and transcriptomics of chitinase gene repertoires in convergent ant-eating mammals finally published in @genomebiolevol.bsky.social

doi.org/10.1093/gbe/...

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Lucie Etienne @lucievirevolte.bsky.social · Feb 7

Congratulations @memerman.bsky.social !! So well deserved!

Your mentorship is incredible - Thank you

Harmit Singh Malik @harmitmalik.bsky.social · Jan 31

Congrats to @memerman.bsky.social for winning the @fredhutch.bsky.social faculty conclave award for education, training, and mentorship. I cannot think of someone more deserving for three decades of transforming lives of trainees (and naive junior colleagues)!

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Lucie Etienne @lucievirevolte.bsky.social · Feb 7

We are looking for a #postdoc to discover cell-autonomous innate immune antiviral factors in mammals, based on newly-identified defense of prokaryotes!
#EvoCure #comparativeImmunology #virology
Please share
@inserm.fr @ciri-lyon.bsky.social @cnrsbiologie.bsky.social
ciri.ens-lyon.fr/teams/lp2l/j...

Postdoc position in comparative immunology and virology — Centre International de Recherche en Infectiologie

A 1-year renewable postdoctoral researcher position is available in our lab (PI: Lucie ETIENNE, CIRI, ENS-Lyon) to discover new antiviral cell-autonomous innate immune factors in mammals, based on new...

ciri.ens-lyon.fr

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Lucie Etienne @lucievirevolte.bsky.social · Feb 5

Congratulations Claire!

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Sorek Lab @soreklab.bsky.social · Jan 23

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity

Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors

A 🧵 1/10

www.cell.com/cell/abstrac...

Structure-guided discovery of viral proteins that inhibit host immunity

Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...

www.cell.com

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François Rousset @francoisrousset.bsky.social · Jan 31

Exciting to see our paper now published 🙌
www.science.org/doi/10.1126/...

In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇

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Lucie Etienne @lucievirevolte.bsky.social · Jan 28

Congratulations Francesca, Veronica, and all coauthors!! 👏

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Francesca Fiorini @frafiorini.bsky.social · Jan 28

Delighted to share our latest work on SARS-CoV-2 Nucleocapsid and Nonsense-Mediated mRNA Decay. 👇
doi.org/10.1093/nar/...

The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2

Abstract. The nonsense-mediated mRNA decay (NMD) pathway triggers the degradation of defective mRNAs and governs the expression of mRNAs with specific char

doi.org

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Jeff Mugridge @jeffmugridge.bsky.social · Jan 9

Final thoughts:
💡TRMT1 cleavage & inactivation may be another mechanism by which SARS-CoV-2 manipulates host tRNA modifications and translation!
🦠We think this could impact viral pathogenesis or phenotypes!
💊Our structure might help understand Mpro substrate recognition or different pockets to drug!

A comical summary of the paper! A short cartoon with 4 panels showing: (1) TRMT1 wanting to transfer methyl groups to tRNA; the tRNA loves this because those methyl groups (on G26) will help its stability and overall translation properties. (2) But, uh oh, here comes the SARS-CoV-2 main protease! (3) The protease takes a big bite out of TRMT1, severing its leg (ie Zinc finger domain); *CHOMP*. (4) TRMT1 and tRNA cry out to one another in grief, as the wounded TRMT1 is no longer able transfer methyl groups to tRNA - disrupting its structure and translation properties!

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