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Reposted by François Rousset

CNRS @cnrs.fr · 2d

#ExpertsCNRS 🔎 Journalistes, en lien avec le #NobelPrize de médecine, le bureau de presse du @cnrs.fr vous propose des scientifiques pouvant vous éclairer sur les travaux des lauréats.

Si vous êtes intéressés :
📞📩 cnrs.fr/fr/contacts

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Reposted by François Rousset

Erin Doherty @erinedoherty.bsky.social · 7d

Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity.

Check out this work co-led with @benadler.bsky.social here:

www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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Reposted by François Rousset

Ben Adler @benadler.bsky.social · 7d

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.

Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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Reposted by François Rousset

Vivek Mutalik @vivekmutalik.bsky.social · 7d

*New preprint*
#phage #phagesky
This is a cool effort lead by Fangchao, Arkin lab, to test a new tech to study phage-host interaction mechanism at scale, in a droplet!
We benchmarked it by using a set of 2 classical coli phages to identify their receptors, impt for generatin data for AI/ML models

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 9d

Droplet-based Random Barcode Transposon-site Sequencing (Droplet RB-TnSeq) to characterize phage-host interactions https://www.biorxiv.org/content/10.1101/2025.09.29.679331v1

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François Rousset @francoisrousset.bsky.social · 7d

Amazing !! Congrats @benmorehouse.bsky.social and co !

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Luuk Loeff @lloeff.bsky.social · 9d

Hiring! 🧬🔬

Ever wondered how bacteria fight off viruses? We’re looking for a PhD student to dive into the molecular basis of newly discovered microbial immune systems, an area of biology where much remains to be uncovered.

RT/share to help us find our next team member!
www.lumc.nl/en/about-lum...

PhD-positie Bacteriële Verdedigingssystemen tegen Virussen | LUMC

Wij zoeken een getalenteerde en gemotiveerde PhD-kandidaat om het onderzoeksteam van Luuk Loeff te versterken. In dit project maak je gebruik van geavanceerde technologieën om te ontrafelen hoe bacter...

www.lumc.nl

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François Rousset @francoisrousset.bsky.social · 12d

Wow 🤯

Caitie McCafferty @computingcaitie.bsky.social · 15d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

Reposted by François Rousset

Kranzusch Lab @kranzuschlab.bsky.social · 13d

You’ve heard of ubiquitination, meet deazaguanylation: Doug Wassarman in our lab discovered phage defense pathways have co-opted Q nucleobase biosynthetic enzymes to catalyze a new form of protein conjugation chemistry @science.org

www.science.org/doi/10.1126/...

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Zamin Iqbal @zaminiqbal.bsky.social · 13d

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 29d

We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social

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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Sep 6

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.

www.science.org

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Reposted by François Rousset

Royal Society Publishing @royalsocietypublishing.org · Sep 5

A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1

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Kranzusch Lab @kranzuschlab.bsky.social · Sep 5

How can we understand the earliest events in evolution of eukaryotic immunity? @yao-li.bsky.social reports incredible molecular fossils of complete bacterial-like operons in eukaryotes that illuminate how animal immunity was first acquired from anti-phage defense

www.biorxiv.org/content/10.1...

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François Rousset @francoisrousset.bsky.social · Sep 5

Effector-triggered immunity (ETI) indirectly detects pathogen effector activity on the host cell.

Kevin Barthes,Tanita Wein and I examine how prokaryotic and eukaryotic viruses deploy similar effectors that activate ETI, underscoring its central role across the tree of life.

tinyurl.com/mr3a3xh2

Viral effectors trigger innate immunity across the tree of life | Philosophical Transactions of the Royal Society B: Biological Sciences

Viruses are ubiquitous biological entities that exert immense selective pressures on their hosts, driving the evolution of diverse innate immune mechanisms across all domains of life. While innate imm...

royalsocietypublishing.org

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François Rousset @francoisrousset.bsky.social · Sep 4

Super excited to receive the ERC starting grant to explore what phage-bacteria interactions can teach us on host-pathogen conflicts 🤩 I'm immensely grateful to my wonderful team and to present and past mentors 🙏

European Research Council (ERC) @erc.europa.eu · Sep 4

📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope

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Helmholtz-Zentrum für Infektionsforschung (HZI) @helmholtzhzi.bsky.social · Sep 4

Im Kampf gegen multiresistente Keime können #Bakteriophagen eine weitere Waffe sein. Für sein Projekt "RIBO-PHAGE" erhält @jenshoer.bsky.social, Nachwuchsgruppenleiter @helmholtz-hiri.bsky.social, nun einen #ERCStG des @erc.europa.eu!🎉 Herzlichen Glückwunsch!
www.helmholtz-hzi.de/media-center...

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François Rousset @francoisrousset.bsky.social · Sep 2

Amazing Jeremy 💪🤯

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François Rousset @francoisrousset.bsky.social · Sep 2

Mind-blowing tour-de-force for synthetic biology and immunity 🤯
Congrats @garbjeremy.bsky.social and @soreklab.bsky.social 🤩

Sorek Lab @soreklab.bsky.social · Sep 2

Preprint: De-novo design of proteins that inhibit bacterial defenses

Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications

Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection

Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

www.biorxiv.org

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Reposted by François Rousset

Sorek Lab @soreklab.bsky.social · Aug 25

Preprint: We discovered phage proteins that sequester diverse immune signaling molecules, including cUMP, cCMP, and N7-cADPR

The first viral sponges to inhibit Pycsar and type IV Thoeris

Congrats to talented leading author Romi Hadary! Read her thread to learn more about our findings

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François Rousset @francoisrousset.bsky.social · Aug 25

Amazing Romi 🙌

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Erin Doherty @erinedoherty.bsky.social · Aug 22

Excited to share our new preprint co-led by @jnoms.bsky.social!

Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

Divergent viral phosphodiesterases for immune signaling evasion

Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...

www.biorxiv.org

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Reposted by François Rousset

Doudna Lab @doudna-lab.bsky.social · Aug 22

New pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨

Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.

Erin Doherty @erinedoherty.bsky.social · Aug 22

Excited to share our new preprint co-led by @jnoms.bsky.social!

Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

Divergent viral phosphodiesterases for immune signaling evasion

Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...

www.biorxiv.org

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Reposted by François Rousset

Alicia Calvo-Villamañán @aliciapcv.bsky.social · Aug 20

This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens

Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

rdcu.be

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Reposted by François Rousset

BejaLab @bejalab.bsky.social · Aug 4

Small uncultured viral-like entities redraw the origin of viruses and cellular compartments www.biorxiv.org/content/10.1...

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