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Reposted by Luke Jostins-Dean

Kathryn Paige Harden @kph3k.bsky.social · 15d

I have been saying this for years:

There is nothing inherently progressive about emphasizing environmental causes over genetic ones.

Bad speculation about environmental causes can also be dangerous.

I wish, though, that the current administration hadn’t illustrated my point so spectacularly.

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Yang Luo @y-luo.bsky.social · Sep 1

This project is in close collaboration with the amazing @lukejostins.bsky.social, and the student will benefit from a multi-disciplinary team! 🌟🧬🧠

Yang Luo @y-luo.bsky.social · Sep 1

🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics

kennedy.ox.ac.uk

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Kaur Alasoo @kauralasoo.bsky.social · Sep 3

Parquet works really well with R as well. I use it all the time to work with GWAS summary statistics that won't fit into memory (our latest metabolite GWAS tested 95M+ variants in UKBB). Here's a minimal example of how to filter data on the fly while reading into R: gist.github.com/kauralasoo/f...

Filtering parquet files with dplyr

GitHub Gist: instantly share code, notes, and snippets.

gist.github.com

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Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · Sep 1

🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics

kennedy.ox.ac.uk

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Luke Jostins-Dean @lukejostins.bsky.social · Aug 25

TIHYLTTW is just too perfect a name to give up, even if it makes it less marketable. One of my all-time favourite book titles.

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Pearl Freier @pearlf.bsky.social · Aug 25

Novartis & Roche collaborated w/ Oxford researchers at the Big Data Institute 2 develop AI model using largest collection of clinical trial data (Novartis-Oxford MS dataset) from >8000 ppl living w/ multiple sclerosis (MS) to reclassify the progression of MS www.ndm.ox.ac.uk/news/using-a... #biosky

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Luke Jostins-Dean @lukejostins.bsky.social · Aug 22

Significant after correcting for 0.98 tests

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Luke Jostins-Dean @lukejostins.bsky.social · Aug 16

Both of these guys talk very directly to my heart

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Luke Jostins-Dean @lukejostins.bsky.social · Aug 16

Both sides of this debate made me feel very warmly about the people of France. www.theguardian.com/society/2025...

Call to ban ‘intolerant’ child-free resorts and hotels in France

Debate grows as Senator Laurence Rossignol says ‘we can’t organise society by separating children off’

www.theguardian.com

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Nightingale Health @nightingalehealth.com · Aug 14

Welcome to our webinar “Multi-omic insights into human disease” by @jeffbarrett.eu on 4 September at 3 p.m. CEST!

Join us for an exploration of how integrating proteomics and metabolomics can deepen our understanding of human health and disease.

Learn more and sign up: www.lyyti.fi/reg/multiomi...

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Luke Jostins-Dean @lukejostins.bsky.social · Jul 19

A true *history of Britain

Luke Jostins-Dean @lukejostins.bsky.social · Jul 19

The first seems to be 18th century, marked by Hume and Gibbon treating the legends as myths built upon a real minor local figure. The second, generally believing that Arthur was entirely fictional (or a broad composite of people) is much more recent (our lifetimes).

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Luke Jostins-Dean @lukejostins.bsky.social · Jul 19

Nicholas Higham has a book that tries to answer that ("King Arthur. Myth-Making and History"). There are basically two stages: when did people stop believing the Arthurian romances were a true historian of Britain, and when did people stop believing Arthur was likely to be a real person at all.

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Luke Jostins-Dean @lukejostins.bsky.social · Jul 19

It's a great book but I don't recall it having anything in particular about when people stopped believing in the truth of the Arthurian legends.

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Yang Luo @y-luo.bsky.social · Jul 16

Amazing news! Excited to be part of this new direction of research.

Kennedy Institute of Rheumatology @kiroxford.bsky.social · Jul 16

Huge news! A £50M MRC CoRE will bring together Manchester & Oxford to study how environmental exposures cause chronic inflammatory disease.

The CoRE will be Directed by Prof Judi Allen (Manchester) & co-Directed by Prof Dame Fiona Powrie, Director of the KIR.

www.kennedy.ox.ac.uk/news/new-ps5...

New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases

A new Medical Research Council Centre of Research Excellence (MRC CoRE) will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases, such as asthma, ...

www.kennedy.ox.ac.uk

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Luke Jostins-Dean @lukejostins.bsky.social · Jul 8

Nice to see evidence we didn't just dream all these loci up.

The link from MAML2 notch signalling in DCs to systemic IL12/23 levels is interesting. Any idea what MAML2 is doing in DCs? I think most of the work to date has been in salivary glands (where MAML2 somatic mutations drive cancer).

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Luke Jostins-Dean @lukejostins.bsky.social · Jul 8

@bradleyomics.bsky.social great work guys, well done

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Tobi Alegbe @tobioinformatics.bsky.social · Jul 8

🚨New preprint just dropped 🚨
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!

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Bradley Harris @bradleyomics.bsky.social · Jul 8

To see which of these underpin susceptibility, we colocalised these with IBD GWAS. Remarkably, we nominate effector genes at an enormous 74 (❗) loci where one has not previously been nominated in @OpenTargets. This therefore SUBSTANTIALLY improves on previous efforts. 10/

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Helena Kilpinen @hkilpinen.bsky.social · Jun 25

Job alert ‼️ @thomasdwkim.bsky.social and I are recruiting a postdoc in single-cell genomics via the NORPOD program of the @nordicembl.bsky.social. Collaboration between @fimm-uh.bsky.social and @dandrite.bsky.social on multimodal data integration in neurodevelopment.
jobs.helsinki.fi/job/Helsinki...

Postdoctoral Researcher in Single-Cell Genomics through the NORPOD program

jobs.helsinki.fi

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Luke Jostins-Dean @lukejostins.bsky.social · Jun 22

My 7-year-old just made a knife out of Lego, and did this:

"I have a knife!"

*Does a few slashes, then poses in a fighting stance"

"and I am going to a gun fight"

Is this from something, or did he make it up himself?

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Reposted by Luke Jostins-Dean

James Lee @dr-james-lee.bsky.social · Jun 9

📢 📢Job alert!📢📢
We have an exciting opportunity for a 4 year post-doc in my lab at @crick.ac.uk‬. This project will take a similar approach to our recent ETS2 paper, published in Nature, to better understand the mechanisms that contribute to IBD tinyurl.com/yx43upnk

Postdoctoral Fellow - Lee Lab

Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Lee Lab Reports to: James Lee [C] Closing Date: 23.59 GMT Job Description: Job titl...

tinyurl.com

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Luke Jostins-Dean @lukejostins.bsky.social · Jun 2

I should probably say, just to be clear, that Nightingale Health Plc does not recommend eating 15 grams of butter on your slice of bread. There are likely to be negative effects on your health if done frequently, and you also just feel sort of oily afterwards.

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Luke Jostins-Dean @lukejostins.bsky.social · Jun 2

If you are interested to know why I have been weighing out 15 grams of butter for my bread, and what it has to do with the metabolomics of aging, sign up to this webinar tomorrow

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Nightingale Health @nightingalehealth.com · Jun 2

📣 Our webinar “Measuring the effects of aging with metabolomic profiling” by @lukejostins.bsky.social is tomorrow! Remember to sign up and join us tomorrow at 3 p.m. CEST.

Sign up: www.lyyti.fi/reg/aging_we...

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