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macdonaldlab.bsky.social
Ryan MacDonald
@macdonaldlab.bsky.social
270 followers 340 following 2 posts
Glia biologist. Vision scientist. Interested in mechanisms of development and ageing in the retina. We love glia. You should too.
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Reposted by Ryan MacDonald
clark-lab-retina.bsky.social
Brian Clark @clark-lab-retina.bsky.social · Aug 6
Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
plosbiology.org
PLOS Biology @plosbiology.org · Aug 5
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
Left: The active DNA methylation cycle. (i) 5mC is added by DNMTs. (ii) The TET enzymes oxidize 5mC to 5hmC. (iii) 5hmC is converted to 5fC and 5caC by the TET enzymes, followed by conversion back to cytosine by TDG and the base-excision repair pathway. (iv) Alternatively, APOBEC converts 5mC to thymine, causing DNA mismatch. Right: H&E staining of an allelic series of TET conditional P21 mutants.
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Reposted by Ryan MacDonald
michelcayouette.bsky.social
Michel Cayouette @michelcayouette.bsky.social · Jul 25
Hi all, we got a grant for a cool project that will follow up of our paper published a few months ago (see below). We will explore how light acts as a morphogen to instruct PCP. If you are looking for a postdoc position and interested in this topic, please reach out!
michelcayouette.bsky.social
Michel Cayouette @michelcayouette.bsky.social · Feb 5
ICYMI our latest paper is now out officially in print (is there still such thing?). And since Dev Cell @cellpress.bsky.social did not select our submission for cover, I post it here. A really cool illustration from my son Zack. www.cell.com/developmenta...
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Reposted by Ryan MacDonald
zebrafishrock.bsky.social
Zebrafish Rock! @zebrafishrock.bsky.social · Apr 3
#ZebrafishCareers 🇬🇧 (Postdoc) #killifish

Link to MacDonald Lab website: zebrafishucl.org/macdonald-la...
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Reposted by Ryan MacDonald
ladyglaucoma.bsky.social
Revathi Balasubramanian @ladyglaucoma.bsky.social · Mar 27
My lab studies mechanisms of pediatric glaucoma and the development of tissues affected (Schlemm's canal and trabecular meshwork). I am getting creative with fundraising because, well... So if you know someone who might be interested in funding our work: joinus.cuimc.columbia.edu/index.cfm?fu...
I'm supporting Your Columbia!
Your Columbia is your opportunity to be a part of the unparalleled research, education, and clinical care that takes place every day at Columbia University Irving Medical Center. It’s a potent and imp...
joinus.cuimc.columbia.edu
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Reposted by Ryan MacDonald
zebrafishrock.bsky.social
Zebrafish Rock! @zebrafishrock.bsky.social · Feb 7
#ZebrafishCareers 🇬🇧 (Postdoc) #killifish
macdonaldlab.bsky.social
Ryan MacDonald @macdonaldlab.bsky.social · Feb 7
We’re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
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macdonaldlab.bsky.social
Ryan MacDonald @macdonaldlab.bsky.social · Feb 7
We’re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
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Reposted by Ryan MacDonald
clark-lab-retina.bsky.social
Brian Clark @clark-lab-retina.bsky.social · Feb 4
First post on this platform is to announce that our preprint is posted to bioRxiv:

bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...
doi.org
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macdonaldlab.bsky.social
Ryan MacDonald @macdonaldlab.bsky.social · Jan 21
Sorry we’ve never tried cultured organs either.
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