Lightnews — Scholar-powered news

Madeline Kavanagh @mads-chem.bsky.social · 7d

Awesome talk from @ox.ac.uk Prof. Alex Bullock @leidenscience.bsky.social today. Neat examples of #neomorphic gain-of-function mutations driving disease by acting as #molecularglues and using #FBDD to expand the #druggability of E3ligases with thesgc.bsky.social‬
an#EUbOPENEN @led3hub.bsky.social

2 7

Reposted by Madeline Kavanagh

Virtual ChemBioTalks @chembiotalks.bsky.social · 14d

The first Flash Talk at the 5th Virtual ChemBioTalks will be given by Jingzhi Fan. He will present on “Metabolomics-Inspired Biomaterials: Calcium Phosphate with Targeted Metabolic Enhancement for Bone Repair”.

Register for free: web.cvent.com/event/60e9f3...

#ChemBio #ChemSky #DrugDiscovery

2 3

Reposted by Madeline Kavanagh

Stephan Hacker @stephanhacker2.bsky.social · 17d

Looking forward to a great @led3hub.bsky.social Lecture by Willem Velema on Thursday. Excited to learn, how his group is targeting RNA to develop novel #antibiotics.

#ChemSky #ChemBio @leidenscience.bsky.social

Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · 17d

We are very much looking forward to the first LED3 Lecture of the academic year on Thursday, September 25th, at 4 p.m.

Willem Velema will talk about his research into targeting bacterial #RNA for #antibiotic development.

www.universiteitleiden.nl/en/science/l...

#ChemSky #ChemBio #DrugDiscovery

2 7

Madeline Kavanagh @mads-chem.bsky.social · Sep 3

Looking for a #PhD in #medicinal #chemistry and #chemical #proteomics focused on #drugdevelopment for #infectiousdiseases?
We have a vacancy!!
Come join our interdisciplinary team @leidenscience.bsky.social & and help develop new approaches to treat mycobacterial infections 😀
tinyurl.com/3srxfr55

PhD Candidate in Chemistry, Proteomics, and Immunology

PhD Candidate in Chemistry, Proteomics, and ImmunologyThe Leiden Institute of Chemistry is looking for a PhD candidate to pursue research on the development of immune-modulatory drugs to treat infecti...

www.universiteitleiden.nl

2 5

Reposted by Madeline Kavanagh

Stephan Hacker @stephanhacker2.bsky.social · Jul 16

Looking forward to hearing about the potential of machine learning for #Biology and #DrugDiscovery from an industry perspective. Register for the Virtual @chembiotalks.bsky.social to hear the perspective of Chris Dallago (@machine.learning.bio) from Nvidia.
#ChemBio #Chemsky #ML #MachineLearning

Virtual ChemBioTalks @chembiotalks.bsky.social · Jul 16

The third talk of the 5th Virtual ChemBioTalks will be given by Chris Dallago (@machine.learning.bio). He will talk about the research at NVIDIA into “Industrial BioML: the coming of age of machine learning for biology”.

Make sure to register for free: https://cvent.me/G1geWW

5 10

Reposted by Madeline Kavanagh

Virtual ChemBioTalks @chembiotalks.bsky.social · Jun 6

Free registration is now open for the 5th Virtual ChemBioTalks on September 30th, 2025.

We are looking forward to a full program including keynote lectures by Sarah O'Connor and @craigmcrews.bsky.social as well as five additional exciting lectures. (1/2)
cvent.me/G1geWW

#ChemBio #Chemsky

1 5 14

Reposted by Madeline Kavanagh

Stephan Hacker @stephanhacker2.bsky.social · May 7

Very excited that Ed Tate will visit us for a @led3hub.bsky.social Lecture on May 22nd and talk about cutting-edge #ChemBio and #chemoproteomics research in the field of #DrugDiscovery. If you are interested, feel free to come by!

#ChemSky

Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · May 7

We are looking forward to the LED3 Lecture of Ed Tate on May 22nd at 4 p.m. in the Gorlaeus building room CM1.26. He will talk about his research on "Targeting Post-translational Modification for Drug Discovery". If you are interested, come by: www.universiteitleiden.nl/en/science/l...

1 6

Madeline Kavanagh @mads-chem.bsky.social · May 1

Great opportunity for #PhD #postdoc to showcase their #chemistry #chemicalprobe #proteomics #chembiol research at the next @chembiotalks.bsky.social
Looking forward to keynotes from @craigmcrews.bsky.social and @oconnorlab.bsky.social and exciting #earlycareer Flashtalks!! #chemsky

Virtual ChemBioTalks @chembiotalks.bsky.social · May 1

Do you want to present your #ChemBio research to a global audience at the 5th Virtual ChemBio Talks?

If you are a #PhD or #postdoc, here is your chance! Apply for a Flash Talk via our abstract challenge. Deadline is June 30th.

#ChemSky

chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

3 4

Madeline Kavanagh @mads-chem.bsky.social · Apr 30

Had a great time today discussing the power of #chemoproteomics to help develop #drugs with novel mechanisms of action today for @flgenomics.bsky.social webinar series. Great to see the #chemistry, #AI #proteomics, and #genomics communities coming together to drive change drug development!

1 4

Reposted by Madeline Kavanagh

Matt Bogyo @mbogyo.bsky.social · Apr 19

If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio
www.sciencedirect.com/science/arti...

Chemical strategies for targeting lipid pathways in bacterial pathogens

Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has b…

www.sciencedirect.com

19 32

Madeline Kavanagh @mads-chem.bsky.social · Apr 16

Exciting Day 3 RACI #MCCB2025 ! Starting with showstopping stories from GateBioscience's Pat Sharp on the development of Sec61 #inhibitors for Prion disease, & Prof. Avril Robertson from UQ on targeting NLRP3 #inflammasomes. Impressive preclinical efficacy fromin both stories!

Reposted by Madeline Kavanagh

HHMI @hhmi.org · Apr 5

Congrats to HHMI Investigator David R. Liu on receiving the 2025 Breakthrough Prize in Life Sciences! He is recognized for developing base editing & prime editing: 2 breakthrough gene-editing technologies that enable the correction or replacement of virtually any genetic mutation. hhmi.news/3RA6shj

HHMI Investigator David R. Liu, smiling, with a graphic of a DNA helix in the background. Text overlay announces his award of the 2025 Breakthrough Prize in Life Sciences.

20 140

Reposted by Madeline Kavanagh

Stephan Hacker @stephanhacker2.bsky.social · Apr 3

Very excited that I will have the chance to work together with @mads-chem.bsky.social, @martola.bsky.social, Daan van der Es, Martijn Verdoes and Paul Geurink on this exciting event. (2/2)

1 4

Madeline Kavanagh @mads-chem.bsky.social · Apr 1

Had an amazing time at #abpp2025 over the last couple of days. Incredible lineup of speakers showcasing why #ABPP and #proteomics have transformational for #drugdiscovery and #chembiol
Already looking forward for #abpp2027 in @LeidenScience

9

Reposted by Madeline Kavanagh

Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · Apr 1

We are very excited that three of our researchers, @mads-chem.bsky.social, @kimmb1.bsky.social and Sander van Kasteren, were successful in obtaining funding through the ZonMw open competition.

Learn more about the three projects here: www.universiteitleiden.nl/en/news/2025...

Chemistry as the key to medical innovation

Is it a coincidence that three chemists from the same department have each independently received a ZonMw grant? 'No,' the researchers agree in unison. 'The role of chemistry in medical biology is bec...

www.universiteitleiden.nl

3 11

Madeline Kavanagh @mads-chem.bsky.social · Mar 27

Really enjoyed hosting @jpoverington.bsky.social from @drughunter.com today for @led3hub.bsky.social lecture @leidenscience.bsky.social Some great insights into how #genetics informs #drug target selection and how we can leverage #chemoinformatics to reduce attrition in #drugdevelopment.

1 6

Reposted by Madeline Kavanagh

Stephan Hacker @stephanhacker2.bsky.social · Mar 25

Impressive talk by Georgia Andriopoulou from the group of @mads-chem.bsky.social of the @led3hub.bsky.social at #Lunteren. She talked about her research into new libraries of covalent compounds with tailored properties for #chemoproteomics identification of new therapeutic targets.
#chemsky #chembio

2 7

Madeline Kavanagh @mads-chem.bsky.social · Mar 24

On #WorldTBday @leidenscience.bsky.social "Dutch Perspective on Mycobacterial Infections" provided insights on #hostpathogen interactions #drugdevelopment & #immunology from global leaders. Unfortunatley, #MDR #infections continue to rise, urgently requiring new #drugs with new #targets

Symposium: A Dutch Perspective on Mycobacterial Infections

On the 24th of March 2025, World TB day, we organize a symposium to connect the Dutch scientific community working on mycobacterial infections. We will cover all aspects of tuberculous or non-tubercul...

www.universiteitleiden.nl

1 1

Madeline Kavanagh @mads-chem.bsky.social · Mar 13

Huge congratulations to the first MSc #graduate from the Kavanagh lab (and future #PhD ) @leidenscience.bsky.social @led3hub.bsky.social Could not be more proud of Jakob and his hard work pushing forward the development of #chemicalprobes to modulate #immunology #chembio #STEMed

2 15

Madeline Kavanagh @mads-chem.bsky.social · Mar 13

Excited to be joining an great line up of speakers at RACI #MCCB2025 in Darwin just a couple of weeks. Looking forward to exciting science with the #ozchem community #chembio #proteomics #drugdiscovery #NT

bit.ly/3PNkUl6

1

Reposted by Madeline Kavanagh

Stephan Hacker @stephanhacker2.bsky.social · Mar 12

Two amazing @led3hub.bsky.social Lectures are coming up:

On March 17th, Jeff Kelly will talk about tackling neurodegenerative diseases.

On March 27th, John Overington will talk about the power of data in Drug Discovery.

Come by, if you are interested!
www.universiteitleiden.nl/en/science/l...

1 3 11

Reposted by Madeline Kavanagh

Stephan Hacker @stephanhacker2.bsky.social · Mar 10

Join us in Leiden on March 17th for the @led3hub.bsky.social Lecture of Jeffery W. Kelly of @scripps.edu.

Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · Mar 10

We are looking forward to the LED3 Lecture of Jeff Kelly from @scripps.edu on March 17th at 4 p.m. in room 15.31 of the Sylvius building. He will talk about "The Scientific Origins of Drugs that Slow Neurodegeneration". If you are interested, please come by. www.universiteitleiden.nl/en/science/l...

3 6

Madeline Kavanagh @mads-chem.bsky.social · Mar 8

Happy #IWD2025 ! Special shout out to all those #STEMwomen today (including my mum!) keep being amazing #mentorsmatter #DEI #standupforscience

3

Reposted by Madeline Kavanagh

Virtual ChemBioTalks @chembiotalks.bsky.social · Feb 24

Whom would you like to hear at our next event?

The planning for the 5th Virtual ChemBioTalks is starting. We are excited for talks by @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale.

Let us know in reply to this post, whom you would additionally like to hear!

7 14

Madeline Kavanagh @mads-chem.bsky.social · Feb 9

Anyone looking to brush up on #ochem should check out this awesome #free resource from @synthesisworkshop.bsky.social Lecture notes, videos, problem sets & more ! #StemEd #chemnerd #medchem #synthesis Also check out their #podcast (The SW Pod) and #youtube lectures!
youtu.be/Yn7o9z_93WY?...

Advanced Organic Chemistry: Hammetts and KIEs

YouTube video by Synthesis Workshop Videos

youtu.be

1