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makris1.bsky.social
Spiros Makris
@makris1.bsky.social
93 followers 110 following 1 posts
Postdoc @actonlab @LMCB_UCL @UCL |Stromal Immunology|
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makris1.bsky.social
Spiros Makris @makris1.bsky.social · Jun 29
Our latest paper is finally out! We are showing the significance of the podoplanin/CLEC-2 signaling axis beyond controlling cellular mechanics and actomyosin contractility.
#fibroblasts #podoplanin #stroma #inflammation

@actonlab.bsky.social

www.cell.com/cell-reports...
Lymph node fibroblast phenotypes and immune crosstalk regulated by podoplanin activity
Makris et al. show that podoplanin regulates the transcription profile of lymph node fibroblasts. Podoplanin deletion drives inflammation, disrupts lymph node architecture, and attenuates stromal/immu...
www.cell.com
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Reposted by Spiros Makris
coffeltlab.bsky.social
Seth Coffelt @coffeltlab.bsky.social · Feb 7
#hiring #postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...
University of Glasgow - Explore - Jobs at Glasgow - Appointments - Research Associate (Breast Cancer Now) [164192]Search iconClose menu iconMenu icon bar 1Menu icon bar 2Menu icon bar 3
www.gla.ac.uk
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Reposted by Spiros Makris
natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · Feb 6
NEW @preprintclub.bsky.social Journal Club of @biorxiv-immuno.bsky.social paper by @makris1.bsky.social @actonlab.bsky.social showing that loss of podoplanin in fibroblastic reticular cells results in decreased antibody levels and smaller germinal centres after immunization
Podoplanin mediates stromal–immune crosstalk in the lymph node - Nature Reviews Immunology
A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.
www.nature.com
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Reposted by Spiros Makris
mdejong.bsky.social
Madelon de Jong @mdejong.bsky.social · Nov 25
Share and help fill this one up! Suggestions via comments or DM! #stroma #fibroblast #MSC

go.bsky.app/KPJMU4
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Reposted by Spiros Makris
actonlab.bsky.social
Sophie Acton @actonlab.bsky.social · Nov 22
Our latest preprint! - led by @makris1.bsky.social
we find that Podoplanin expression in lymphoid tissue fibroblasts regulated their inflammatory signalling and crosstalk with immune cell populations
doi.org/10.1101/2022...
single cell RNAseq data showing shifts in fibroblast phenotypes after genetic deletion of Podoplanin in lymph node stroma.
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