Lightnews — Scholar-powered news

Reposted by Marah C Runtsch

Kate Holterhoff, PhD @kateholterhoff.com · 4d

We are all Dr. Brunkow 😴
“Dr. Brunkow said she did not expect to win a Nobel Prize. ‘My phone rang, and I saw a number from Sweden and thought, well that’s just spam of some sort, so I disabled the phone and went back to sleep,’“ www.nytimes.com/2025/10/06/h...

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems

www.nytimes.com

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Reposted by Marah C Runtsch

Jason Shepherd @jasonsynaptic.bsky.social · 4d

#goals

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Marah C Runtsch @marahclarice.bsky.social · 8d

Happy 30th anniversary to one of the greatest, most life-changing albums of all time, What’s the Story, Morning Glory? #oasis

Marah C Runtsch @marahclarice.bsky.social · 16d

Congratulations to Gina and her team on the hard work and great effort; happy to be included in such a cool story! #immunosky #immunometabolism

Edward Nirenberg @enirenberg.bsky.social · 16d

One thing that comforts me in the current era is that, despite everything, really cool science continues to be published:

www.science.org/doi/10.1126/...

This could be a breakthrough for managing so many autoimmune diseases (still, in mice—don't get too excited).

Adenosine 2A receptor–dependent activation of AMPK represses TH17 cell pathogenicity through epigenetic and metabolic reprogramming

Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity.

www.science.org

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Oded Rechavi @odedrechavi.bsky.social · 22d

Only single cell sequencing of the all these post docs will reveal why

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Marah C Runtsch @marahclarice.bsky.social · Aug 14

Still riding this high of seeing one of the greatest gigs of all time with some of the greatest people 💕 #oasis #murrayfield #feelingsupersonic #morningglory

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Marah C Runtsch @marahclarice.bsky.social · Jul 21

Dear Europeans who like to suffer through the 30+ degree weather, unable to sleep:

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Andrew Monteith @ajmonteith.bsky.social · Jul 7

Just out in Infection and Immunity!
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen

Live fast, die young: neutrophils streamline their metabolism to maximize inflammation | Infection and Immunity

Cell metabolism plays a key role in shaping immune cell differentiation and function, with each immune cell subset depending on distinct metabolic pathways. While there have been extensive studies and...

journals.asm.org

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Johan Duchêne @johanduchene.bsky.social · Jul 7

A comparison of mouse vs human tumor microenvironments shows a major difference.

Mouse TMEs have more macrophages, while human TMEs have more T cells.

Chemokine expression patterns are also different.

Learn more: www.biorxiv.org/content/10.1...

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Marah C Runtsch @marahclarice.bsky.social · Jun 12

You can also access the full-text here via the free share link:

authors.elsevier.com/c/1lFk1bEXZe...

#immunosky

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Marah C Runtsch @marahclarice.bsky.social · Jun 12

Can we use what we’ve learned so far about #immunometabolism in macrophages and neutrophils as cancer immunotherapy? Not yet, but someday. I’m happy to share our latest review, summarizing the state of the field in the context of #myeloidcells and #lungcancer

www.sciencedirect.com/science/arti...

Targeting myeloid cell immunometabolism to improve current non-small cell lung cancer therapies

Although recent advancements in immunotherapy have improved clinical outcomes, non-small cell lung cancer (NSCLC) is still the deadliest cancer type, …

www.sciencedirect.com

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Marah C Runtsch @marahclarice.bsky.social · May 28

Mark your calendars for the next T Cell Europe Lecture, featuring Stefano Angiari sharing his latest #immunometabolism research, from @medunigraz.at June 3rd at 5pm CET 11am EST

www.t-cells.eu

T-Cell Connect Europe

EFIS-IL study group T CELL CONNECT EUROPE (TCC_EUROPE)

www.t-cells.eu

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Marah C Runtsch @marahclarice.bsky.social · May 15

Attending the Carrie and Lowell tour on the eve of Mother’s Day 2015 in New Orleans is still one of the best concerts I’ve ever seen and truly a formative experience in my life 💕 thank you Sufjan

Marah C Runtsch @marahclarice.bsky.social · May 15

archive.ph/qvH9r

A great interview with one of my favorite “famous” people, Sufjan Stevens, in celebration of the 10th anniversary of one of the greatest and most developed albums of all time #carrieandlowell

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Lindsey Van Haute @lindseyvanhaute.bsky.social · May 15

P-hacking

Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.

www.nature.com/articles/d41...

P hacking — Five ways it could happen to you

Some data practices can lead to statistically dubious findings. Here’s how to avoid them.

www.nature.com

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Medizinische Universität Graz @medunigraz.at · Mar 24

🚀 Förderung für engagierte Forscher*innen! 💡🔬 Bei der Pioneering Minds Award Ceremony wurden die Forschungsförderungspreise "GESUNDHEIT3000" verliehen. Der Verein #MEFOgraz prämiert innovative Projekte zur Verbesserung von Vorsorge, Früherkennung, Diagnose oder Behandlung ➡ https://bit.ly/4i7H66d.

Eine Gruppe von Leuten posiert für ein Foto.

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European Research Council (ERC) @erc.europa.eu · Apr 2

#FactCheckingDay promotes media literacy and the importance of reliable information in the fight against disinformation.

ERC Scientific Council member @lukeanthonyoneill.bsky.social shares why acting to counter disinformation matters to him as a scientist. 👇

#FactsMatter

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Andres Hidalgo @drusqui.bsky.social · Mar 19

Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...

Matrix-producing neutrophils populate and shield the skin

Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...

rdcu.be

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Marah C Runtsch @marahclarice.bsky.social · Mar 20

I’m a US citizen living and working in Europe as a scientific researcher, and I told my partner last night that we should avoid going back at all costs. This was before the news of a French researcher being detained came out. It sucks because I miss my family, I guess they should come here

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Marah C Runtsch @marahclarice.bsky.social · Mar 18

Reviewers! Your job is to improve the scientific quality and integrity of a paper and make suggestions to solidify conclusions, not to gatekeep and make authors jump through unnecessary hoops to reach some invisible bar you’ve set in order to stroke your ego! we’ve all got it tough, don’t make worse

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Marah C Runtsch @marahclarice.bsky.social · Mar 13

And yesterday I got an email from the university that some of the benefits I was apparently owed from 2024 weren’t paid correctly, so I’ll randomly get an extra fee from them. Such a stark contrast of what I’m used to in the States

Marah C Runtsch @marahclarice.bsky.social · Mar 13

My favorite part about living in Austria is that at random times I’ll get a letter saying “oops we owe you money!” from the electric company, employer, landlord, etc. My landlord randomly lowered my rent by €50/month and then sent me back the difference. Jarring as an American (in a good way)

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Gina DeNicola @ginadenicola.bsky.social · Mar 11

Fascinating work from MALDI master Ramon Sun and collaborators on glycogen metabolism in NSCLC. A real tour de force and such beautiful images 😍 www.nature.com/articles/s42...

Glycogen drives tumour initiation and progression in lung adenocarcinoma - Nature Metabolism

Clarke, Hawkinson and colleagues study the contribution of glycogen accumulation in the onset and progression of lung cancer.

www.nature.com

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Agnel Sfeir @agnelsfeir.bsky.social · Mar 10

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

Engineering mtDNA deletions by reconstituting end joining in human mitochondria

Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…

www.sciencedirect.com

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Marah C Runtsch @marahclarice.bsky.social · Mar 7

I love you, @theonion.com

The Onion @theonion.com · Mar 6

Charli XCX Does Line Of Coke With 11-Year-Old Make-A-Wish Fan

MINNEAPOLIS—In a touching moment that left the terminally ill child excitedly rambling and beaming from ear to ear, witnesses confirmed Friday that Charli XCX had done a line of coke with 11-year-old ...

theonion.com

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