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Marcell Harhai

@marcellharhai.bsky.social

250 followers 210 following 5 posts

MD on a PhD journey 🌱 | moon-tracker, ballroom dancer, roller skate-enthusiast 🌝💃🛼 🇭🇺🇸🇪🏳️‍🌈he/him 📍🇨🇭 @jourdainlab.bsky.social, @dib-unil.bsky.social, @unil.bsky.social https://www.linkedin.com/in/marcellharhai

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Marcell Harhai @marcellharhai.bsky.social · Jul 28

Here it is❗️Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports by Cell Press! 🎉

Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫

www.cell.com/cell-reports...

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease

Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

www.cell.com

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Marcell Harhai @marcellharhai.bsky.social · Jul 28

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease

www.cell.com

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Marcell Harhai @marcellharhai.bsky.social · Jul 15

Happy to have been part of this exciting mito project with my favourite experiment - the Seahorse. See the freshly published article below! 🧫

www.sciencedirect.com/science/arti...

POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis

Evasion of programmed cell death (PCD) is a hallmark of cancer, yet the mechanisms underlying resistance to ferroptosis – an iron-dependent form of PC…

www.sciencedirect.com

Reposted by Marcell Harhai

Alexis A. Jourdain @jourdainlab.bsky.social · Mar 14

🚨 New preprint available! Third and final in the #CRISPR screen series!🚨

👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis

www.biorxiv.org/content/10.1...

By A. Strefeler in collaboration with Dave Pagliarini and team.

@DIB_UNIL @FBM_UNIL

🧵 1/9

www.biorxiv.org

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Reposted by Marcell Harhai

Alexis A. Jourdain @jourdainlab.bsky.social · Jan 30

New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...

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Reposted by Marcell Harhai

Juan C. Landoni 🔬 @jclandoni.bsky.social · Nov 17

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪

www.annualreviews.org/content/jour...

#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

Sub compartments of mitochondria graphic

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Marcell Harhai @marcellharhai.bsky.social · Jan 30

🧪 ‼️

Alexis A. Jourdain @jourdainlab.bsky.social · Jan 30

Marcell Harhai @marcellharhai.bsky.social · Jan 30

First PhD manuscript preprint OUT NOW! ‼️

🧫 New galactose #CRISPR screening strategy
📝 Updated OXPHOS-regulating gene inventory
🧬 #FAM136A in the IMS
👂 Mito defects in #Ménière’s disease

All come together in our latest work available at www.biorxiv.org/content/10.1...

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Reposted by Marcell Harhai

Alexis A. Jourdain @jourdainlab.bsky.social · Jan 18

Celebrating the New Year in style! Best wishes from the Jourdain Lab 🥌🫕🇨🇭

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Marcell Harhai @marcellharhai.bsky.social · Dec 23

Exciting new work on mitos! 💫

Juan C. Landoni 🔬 @jclandoni.bsky.social · Dec 23

Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪