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Juan C. Landoni 🔬

@jclandoni.bsky.social

2.6K followers 1.9K following 120 posts

Mitochondriac 🔬 Postdoc @EPFL Manley lab of Experimental Biophysics 🧪 Ph.D. @HelsinkiUni 🇦🇷🇫🇮🇪🇺🇨🇭🏳️‍🌈 (he/él) linktr.ee/jclandoni

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Juan C. Landoni 🔬 @jclandoni.bsky.social · Dec 23

Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

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Reposted by Juan C. Landoni 🔬

Juan C. Landoni 🔬 @jclandoni.bsky.social · Nov 12

#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!

#Mito #Mitochondriac

go.bsky.app/J6Bu5fL

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Juan C. Landoni 🔬 @jclandoni.bsky.social · 4d

Who's coming next week? 🤩🔬

#EESImaging #SeeingisBelieving

EMBL Events @events.embl.org · Jul 8

📣 Do you want to be part of #EESImaging, the exciting symposium that brings together leading innovators in imaging technologies and biological applications?

Then hurry up and submit your abstract! The deadline is tomorrow ⏰ https://s.embl.org/ees25-09-bl

Reposted by Juan C. Landoni 🔬

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Reposted by Juan C. Landoni 🔬

American Society for Cell Biology @ascbiology.bsky.social · 19d

From MBoC: Wallace F. Marshall (UCSF) and team profile the giant ciliate Stentor pyriformis—symbiotic algae in microtubule baskets, symbiont-dependent phototaxis, and a standard genetic code. Paper: www.molbiolcell.org/doi/10.1091/... #CellBiology

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Juan C. Landoni 🔬 @jclandoni.bsky.social · Sep 7

"Who needs a 30x zoom anyway?"
I just found out the answer 🌙🤩

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Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 26

Proof that I also care about other organelles 😁🔬
🟢 #ER 👉👈 #Mitochondria 🟣

Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 25

Shout-out to @lycasworks.bsky.social for the push and code seed and copilot for the rocky but huge help 🤖

Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 25

Trying my hand at HTML/CSS using @github.com hosting for a new personal website 💻 Highly recommend!

jclandoni.github.io

Comments/tips welcome (should look nicer on desktop but mobile should work too).

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Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 22

Still not a bean 🫘

#Mitochondria (and friends) in #retina cells 👀 EM tomography 🔬🧪

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Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 20

So excited to follow the opening symposium of #SWAN 🦢[Sustainable Wellbeing Across Lifespan] at @helsinki.fi today! Congrats to @awartiovaara.bsky.social and all members for the exciting ongoing and future reseach!

#mitochondria #metabolism #aging #health

Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 19

Order, chaos & complexity

#Mitochondria in #muscle cells 💪🔬, color-coded by 3D depth 🧪

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Reposted by Juan C. Landoni 🔬

Society for Developmental Biology @socdevbio.bsky.social · Aug 18

🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio

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Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 6

@schmidtocean.bsky.social

Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 6

Link of ‪‪@schmidtocean.bsky.social‬ YouTube channel with all the dives (there's SO many).

It's perfect second screen content 🤩🦀🪸🦑

www.youtube.com/watch?v=lcM8...

Lance 36 Mar Del Plata Canyon | SOI Divestream 820

YouTube video by Schmidt Ocean

www.youtube.com

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Juan C. Landoni 🔬 @jclandoni.bsky.social · Aug 6

In case you haven't heard, #Argentinian scientists are live-streaming their deep-sea mission with real-time interactive commentary.

It's genius, mesmerising, and triggering huge public interest and support for #science funding 🐙🧪 And the memes are great! #CONICET #MarDelPlataCanyon

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Reposted by Juan C. Landoni 🔬

Marcell Harhai @marcellharhai.bsky.social · Jul 28

Here it is❗️Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports by Cell Press! 🎉

Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫

www.cell.com/cell-reports...

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease

Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

www.cell.com

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Reposted by Juan C. Landoni 🔬

Alexis A. Jourdain @jourdainlab.bsky.social · Jul 28

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉

🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres

www.cell.com/cell-reports...

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease

www.cell.com

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Reposted by Juan C. Landoni 🔬

Alexis A. Jourdain @jourdainlab.bsky.social · Jul 28

Congrats to PhD student @marcellharhai.bsky.social , who joined the lab 2y ago (!) and led this work, to second author M. Foged, and to all our collaborators!

We are thankful to our funding sources including the @FSRMM, Novartis and @snsf.ch.

@dib-unil.bsky.social @fbm-unil.bsky.social

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Reposted by Juan C. Landoni 🔬

Tatjana Kleele @tatjanakleele.bsky.social · Apr 14

Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists!
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...

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Juan C. Landoni 🔬 @jclandoni.bsky.social · May 1

Touché 😂😂😂

Juan C. Landoni 🔬 @jclandoni.bsky.social · May 1

Is there still a reason for dumping figures at the end of manuscripts instead of in-text, even for #BioRxiv preprints? My scroll-finger is exhausted... 🙏🧪📜

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Reposted by Juan C. Landoni 🔬

Juan C. Landoni 🔬 @jclandoni.bsky.social · Nov 17

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪

www.annualreviews.org/content/jour...

#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

Sub compartments of mitochondria graphic

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Juan C. Landoni 🔬 @jclandoni.bsky.social · Apr 7

Want to capture elusive events without stressing out your cells? Check out @wl-stepp.bsky.social hybrid-EDA! A smart microscopy approach to detect events in phase, and only image when it matters! 🔬🧫🧪

www.biorxiv.org/content/10.1...

@sulianamanley.bsky.social @maweigert.bsky.social

Smart hybrid microscopy for cell-friendly detection of rare events

Fluorescence microscopy offers unparalleled access to the spatial organization and dynamics of biological events in living samples, yet capturing rare processes over extended durations remains challen...

www.biorxiv.org

Reposted by Juan C. Landoni 🔬

Suliana Manley @sulianamanley.bsky.social · Apr 6

A key insight was building temporal information and memory into the ANN architecture. A huge thanks to all, especially our ‘smart’ (in so many ways) partner @maweigert.bsky. We could now detect local depolarization following constriction, using commonly used (bleachy TMRE) fluorescent biosensors.

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