This was a delightful meeting, thank you @nynkedekkerlab.bsky.social, @achilleskap.bsky.social , & @lumicks.bsky.social . I had a great time meeting UK’s young single molecule enthusiasts, so many exciting posters!

Interesting! Scientists outside of Europe looking to move to the EU or Switzerland can benefit from this funding opportunity, it includes up to an additional €2 million beyond the grant cap for setup costs.

Eep @maweigert.bsky.social @jclandoni.bsky.social

A key insight was building temporal information and memory into the ANN architecture. A huge thanks to all, especially our ‘smart’ (in so many ways) partner @maweigert.bsky. We could now detect local depolarization following constriction, using commonly used (bleachy TMRE) fluorescent biosensors.

Our latest preprint www.biorxiv.org/content/10.1..., describes Willi Stepp’s project to make smart microscopy even gentler by doing event detection in phase contrast. We developed neural networks to detect mito-LD and mito-lysosome contacts, as well as mitochondrial pre-fission constrictions.

Following the great success of the 2024 event, @ox.ac.uk and LUMICKS proudly present the second UK-Ireland symposium focusing on single-molecule research!

The abstract deadline, 7 March, is approaching fast. Secure a talk or poster by registering now > bit.ly/4gYPPpQ

Rockin’ out at EMBO in situ with @lycasworks.bsky.social @jonasries.bsky.social Christian Zimmerli, Mark Bates 🤘🔬

MBL Physiology is totally invigorating, it’s a joyful mixture of: frontier scientific discoveries, kick-a$$ microscopes, and lovely, brilliant, generous ppl. I can’t wait for the summer!

This was an amazing collaboration, we had the luxury of years of great conversations with @wallaceucsf.bsky.social and his team, as well as our other @HFSP partners @anjbadri.bsky.social and Johan Paulsson. Thanks for telling the story here, Wallace!

Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

But what triggers pearling, and how can we make sense of the distinct morphological changes that take place? We pinpoint several perturbations that differentially impact membrane tension, elasticity, or osmotic pressure, and present a unifying framework: t.ly/yTsPr Collab with Calico Labs.

Nucleoids are known to be regularly spaced along mitochondria, important for their inheritance and maintenance of the local proteome. We identified pearling, a Plateau-Rayleigh type instability described since the 1980s, to be responsible: t.ly/KKmGK. Collab with JLS lab @hhmijanelia.bsky.social

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

This work is very interesting, nice to see cybergenetics spreading beyond systems biology!

I’m excited to join this session organized by Assaf Zaritsky and Megan Driscoll for the "Beyond Pretty Pictures" subgroup. I’ll share our latest on Smart Microscopy and mitochondria.
#cellbio2024 @ascbiology.bsky.social

Sat. Dec. 14, 11:15am, Rm 30C

plan.core-apps.com/ascbembo2024/e…

We are so excited that @janfunkey.bsky.social has agreed to give the keynote seminar for @qiatcshl.bsky.social 2025 @cshlnews.bsky.social! 🔬🖥️ 🛤️ Applications due 1/31/2025. t.co/x87ngy34UC

Figure description: the indubitable cell-nuclei, partially furnished with nucleoli, are there seen, with isolated small dark granules between them.

Still on my oldies kick. Schwann proposed in his MDCCCXLVII monograph that muscle came from cell coalescence. "filaments are formed, which, in some situations, have an appearance like strings of pearls ... At a subsequent period, all trace of granules or division in the filament vanishes ..."

We do ExM! Would love to be added, thank you 😁

Hi Beth, nice to see you here — please add me 😁

Please include me, my lab and I are microscopy fanatics 😁

I lack the words to describe the magic!

I’m reading some old mito classics, Margaret Reed and Walter Harmon Lewis with their camera lucida renderings. From various sources I thought the 1914 Science paper was ‘the one’, but on jstor there were no figures. Instead, it’s the 1915 AJA paper that’s a goldmine (Figs 6 & 10). Am I mistaken?

Here is a blue sky — an auspicious sign for the day I joined bluesky? Enjoying lovely Puerto Varas for the Chilean Cell Biology Meeting with my host Veronica Eisner. 💚