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mareikealbert.bsky.social @mareikealbert.bsky.social · 19d

Proud to see your story featured on the cover of #Neuron! 🤩

Along with a great #preview from Fides Zenk lab @epign.bsky.social

www.cell.com/neuron/abstr...

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mareikealbert.bsky.social @mareikealbert.bsky.social · 21d

Thank you for highlighting our work and putting into perspective! ☺️

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EpiGN - Fides Zenk Lab @epign.bsky.social · 21d

Excited to share our News & Views in Neuron, co-authored with Yong-Qi Gao 🎉🧠

👉 www.sciencedirect.com/science/arti...

It highlights the fantastic new work from the @mareikealbert.bsky.social lab.

Unlocking the epigenome: Single-cell histone profiling in cortical development

Ditzer et al. used single-cell cytometry by time-of-flight-based method for epigenetic analysis to profile histone modifications in the primary human …

www.sciencedirect.com

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mareikealbert.bsky.social @mareikealbert.bsky.social · Sep 6

Huge congrats 🥳 So well deserved!

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TUD | Center for Regenerative Therapies Dresden (CRTD) @crtd-tud.bsky.social · Sep 4

🥳 Congratulations to our postdoc, Dr. Anna Czarkwiani @aniaczark.bsky.social, on receiving the ERC Starting Grant @erc.europa.eu!

With €2 million in funding, Anna will explore the biology of gravisensation and uncover insights into related disorders. 🧠

#CMCBnews @tudresden.bsky.social #ERCStG

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German Stem Cell Network GSCN @gscnoffice.bsky.social · Aug 22

GSCN 2025 Young Investigator Award goes to @bulutkarslioglu.bsky.social of the Max Planck Institute of Molecular Genetics in Berlin.
Find PR here www.gscn.org/ #stemcells #stammzellen #epigenetics #genetics @maxplanck.de @mdc-berlin.bsky.social @www.helmholtz-munich.de @bihatcharite.bsky.social

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TanentzapfLab @tanentzapflab.bsky.social · Aug 13

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

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German Stem Cell Network GSCN @gscnoffice.bsky.social · Aug 14

Workshop Single Cell Genomics on 13 & 14 Oct in @www.helmholtz-munich.de , right before the @gscnoffice.bsky.social 13th Conference. Register and be part!
#stemcells #singlecell #genomics #data #stammzellen #organoids

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katja heuer @k4tj4.bsky.social · Jul 27

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To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

📣 Proud of this fantastic work by two amazing PhD students Nora Ditzer and Ezgi Senoglu from @crtd-tud.bsky.social. 🥳 👏 Huge thanks to all co-authors! Enjoy the read. (11/11)

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

Overall, this study comprehensively characterizes the epigenetic state of specific neural cell types and highlights a novel role for H3K27me3 in regulating the ECM composition in the human developing neocortex. (10/11)

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

Intriguingly, pharmacological PRC2 inhibition in human cortical organoids induces increased production of the ECM components Syndecan 1 and Laminin alpha 1. (9/11)

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

Our findings are especially interesting considering previous results from the Hippenmeyer lab, where PRC2 knockout in individual cells of the mouse cortex suggested a non-cell autonomous mechanism for the regulation of NPC fate decisions by PRC2. (8/11)

www.science.org/doi/epdf/10....

www.science.org

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

Our cell type-specific profiling of the genome-wide H3K27me3 profile not only identified neuronal differentiation, but also extra-cellular matrix (ECM) genes as targets of PRC2. (7/11)

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

Whereas a recent study from the Treutlein lab and @epign.bsky.social revealed a role of PRC2 in regulating the exit from pluripotency, we now dissect the role of PRC2 within the neural lineage after the initial cell fate commitment. (6/11)

www.nature.com/articles/s41...

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems - Nature Neuroscience

The mechanisms underlying human cell diversity are unclear. Here the authors provide a single-cell epigenome map of human neural organoid development and dissect how epigenetic changes control cell fa...

www.nature.com

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

We found that loss of H3K27me3 in human cortical organoids induces a shift of neural progenitor cell proliferation towards differentiation that results in reduced organoid size. (5/11)

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

Here, we performed pharmacological inhibition of PRC2 in human cortical organoids from week 3 to 8, leading to a near complete loss of H3K27me3, and studied NPC behaviour. (4/11)

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

These results beautifully align with a recent study from the Studer lab where PRC2 was shown to contribute to an epigenetic barrier that mediates the protracted maturation of human neurons compared to other species. (3/11)

www.nature.com/articles/s41...

An epigenetic barrier sets the timing of human neuronal maturation - Nature

The slow maturation of human neurons is regulated by epigenetic modification in nascent neurons, mediated by EZH2, EHMT1, EHMT2 and DOT1L.

www.nature.com

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

We apply an innovative, highly multiplexed approach, Epi-CyTOF, to study > 30 epigenetic modifications at single-cell level in the human developing neocortex. We identify H3K27me3, deposited by PRC2, as the modification with the strongest cell type-specific enrichment. (2/11)

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mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.

@crtd-tud.bsky.social @cp-neuron.bsky.social

www.sciencedirect.com/science/arti...

A thread below 👇

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TUD | Center for Regenerative Therapies Dresden (CRTD) @crtd-tud.bsky.social · Jul 23

How important is #epigenetics for human brain?

Researchers led by @mareikealbert.bsky.social used brain organoids 🧠 🧫 and Epi-CyTOF to show that histone methylation controls how brain cells multiply and how big the organoid grows.

Read more ➡️ tud.link/4ywe3g

#neuroscience #CMCBnews

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Deutsche Forschungsgemeinschaft @dfg.de · Jul 17

Rund 150 (!) aktuell und ehemalig Geförderte waren beim diesjährigen #EmmyNoether-Jahrestreffen - und es war wieder einmal lustig, produktiv, sonnig, kollaborativ, synergetisch, kommunikativ und noch viel mehr. 😊
Kurzer Bericht, mehr Impressionen & die Präsentationen zu den Talks:
fcld.ly/ent2025

Bilderstrecke aus 6 Fotos: Gruppenaufnahme der Teilnehmer*innen am See in Potsdam und weitere Personen-Abbildungen in kommunikativen Situationen

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Sandra Hake @hake-chromatin.bsky.social · Jul 16

Join us!!!!!

THE Symposium for all Chromatin and Epigenetics experts and 'lovers' this year!!!

Gesellschaft für Genetik @gfgenetik.bsky.social · Jul 16

🎉 Join us at the upcoming GfG Symposium "Epigenetics & Chromatin" in Giessen, Sept 24–26, 2025!
Amazing speakers, low registration fee, € 300 prizes for best poster & short talk, + free GfG membership for non-members.

Please RT!

express.converia.de/frontend/ind...

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Mauricio Rocha @rocha-lab.bsky.social · Jul 10

Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.

mpi-muenster.mpg.de/career

Max Planck Institute for Molecular Biomedicine @mpi-muenster.bsky.social · Jul 10

We are looking for a #Postdoc with a great interest in biological robustness to lead a project investigating the self-correction capabilities of the developing nervous system. Join us at the @rocha-lab.bsky.social Rocha lab @mpi-muenster.bsky.social!

jobs.mpi-muenster.mpg.de/jobposting/0...

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Martin Weigert @maweigert.bsky.social · Jul 10

Do you like developing new AI vision methods for microscopy image analysis? You love theory & implementation? 1 week left to apply for a fully funded PhD position in our lab in Dresden 🇩🇪! Topics: object detection/tracking, multimodal models & more. DM/email for details! #PhD #AcademicJobs #GPUsgoBrr

Vacancy ID 12244

www.verw.tu-dresden.de

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