Lightnews — Scholar-powered news

MargolisLab @margolislabnyu.bsky.social · 20d

Big congratulations to postdoc @sarahanajjar.bsky.social on receiving a NIH K01 award to study serotonergic mechanisms of pain! 🌟 A huge step toward independence and groundbreaking discoveries ahead! 👏
@karapedsgastrodoc.bsky.social

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

MargolisLab @margolislabnyu.bsky.social · Sep 2

Cool new study showing a comprehensive map of neuroimmune interactions throughout the gut!
www.pnas.org/doi/full/10....

PNAS

www.pnas.org

MargolisLab @margolislabnyu.bsky.social · Sep 2

@karapedsgastrodoc.bsky.social

MargolisLab @margolislabnyu.bsky.social · Sep 2

New research highlights a stomach–brain connection in mental health.
👉 Stronger frontoparietal coupling to gastric rhythms = a marker of poorer mental health (anxiety, depression, stress, well-being).
Visceral rhythms aren’t just gut feelings, they shape our emotions
www.nature.com/articles/s44...

Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health

Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...

@karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @linyhung.bsky.social @chalysthalee.bsky.social

1 1

MargolisLab @margolislabnyu.bsky.social · Aug 29

Happy Birthday to the best mentor ever, Prof. Margolis! 🥳 Thank you for always guiding and supporting us, we’re so lucky to learn from you!
@karapedsgastrodoc.bsky.social

2

MargolisLab @margolislabnyu.bsky.social · Aug 15

3

MargolisLab @margolislabnyu.bsky.social · Aug 15

Amazing week at ANMS 2025! 🌟
Sarah, Chalystha, Lin and Kara gave fantastic talks with Chalystha winning the Frank Hamilton Travel Award and Sarah named a Young Investigator Forum Fellow. Kara’s plenary lecture was a highlight, along with meeting Nobel laureate David Julius.

A gut sense for a microbial pattern regulates feeding - Nature

MargolisLab @margolislabnyu.bsky.social · Jul 24

New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues.
@karapedsgastrodoc.bsky.social

🔗 www.nature.com/articles/s41...

A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.

3 10

Reposted by MargolisLab

Chalystha Lee @chalysthalee.bsky.social · Jul 15

Just back from a great week in Vienna for #ISSR2025. I am grateful for the travel award and the opportunity to share my work. Big thanks to @karapedsgastrodoc.bsky.social and Mike Gershon for their steady support in the lab and my career. Loved connecting with 5-HT researchers from around the world!

1 1 5

Reposted by MargolisLab

Chalystha Lee @chalysthalee.bsky.social · Jul 8

@karapedsgastrodoc.bsky.social gave a fantastic talk on the lab's important work on SSRI use in the gastrointestinal tract
@margolislabnyu.bsky.social highlighting @linyhung.bsky.social and @sarahanajjar.bsky.social 's work!
@nyupainresearch.bsky.social

1 1 3

MargolisLab @margolislabnyu.bsky.social · Jun 27

Our amazing mentor and team lead @karapedsgastrodoc.bsky.social is now officially Professor Margolis! 👏👩‍🏫
She’s the definition of supportive, visionary, and unstoppable! no one deserves it more!
Feeling so lucky to be part of her team 💜
#ProfessorKara #WomenInScience #ProudTeam 💫🌟

Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice - Nature

MargolisLab @margolislabnyu.bsky.social · Jun 26

The Fattahi Lab successfully transplanted hPSC‑derived nitrergic enteric neurons into NO‑neuron–deficient mice, restoring gut motility, and created scalable 2D/3D human ENS models to support drug discovery and cell‑therapy approaches for enteric neuropathies.

www.nature.com/articles/s41...

A study presents a strategy based on human pluripotent stem cells for treating neurodegenerative disorders of the gastrointestinal tract.

Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study - Nature Metabolism

MargolisLab @margolislabnyu.bsky.social · Jun 24

A new study shows that food structure plays a key role in determining which gut hormones are released.
@karapedsgastrodoc.bsky.social

#GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege

📖 Nature Metabolism
www.nature.com/articles/s42...

In this randomized crossover pilot study, the authors collected human gastrointestinal digesta using a unique intubation technique to compare how meals with contrasting cellular structures affect post...

Blood-based T Cell Diagnosis of Celiac Disease

1 1

MargolisLab @margolislabnyu.bsky.social · Jun 20

🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌
Game-changer for gut health.
sciencedirect.com/science/arti...

#guthealthmatters #WBAIL2
@karapedsgastrodoc.bsky.social

Current diagnosis of celiac disease (CeD) is inaccurate in patients following a gluten-free diet (GFD). Blood-based diagnostics targeting gluten-speci…

sciencedirect.com

1 1

MargolisLab @margolislabnyu.bsky.social · Jun 2

Big congrats to @linyhung.bsky.social on her Nature Reviews Journal Club piece spotlighting gut serotonin as a target for mood disorder treatment!
@karapedsgastrodoc.bsky.social

file:///C:/Users/Eb4415/Downloads/Hung-2025-Nature_Reviews_Gastroenterology_&_Hepatology.pdf

3

MargolisLab @margolislabnyu.bsky.social · Jun 2

@chalysthalee.bsky.social @taeseonwoo.bsky.social @sarahanajjar.bsky.social @linyhung.bsky.social @danielxjuarez.bsky.social

MargolisLab @margolislabnyu.bsky.social · Jun 2

🎉 Big wins for the Margolis Lab at AMPIRS 2025!

👏 Chalystha and Lin rocked their talks, Taeseon and Daniel nailed their posters, and Sarah delivered an epic flash talk!

🏆 Huge congrats to Lin and Sarah for taking 1st place! So proud of this amazing team! 💜🧠
@karapedsgastrodoc.bsky.social

Reposted by MargolisLab

NYU Pain Research Center @nyupainresearch.bsky.social · May 30

Titles:
Maria Fernanda: Neuropilin-1 Modules nerve growth factor signaling to sustain periorbital pain
Zhiting Gong: Mice lacking LRP1 in Schwann cells exhibit orofacial pain
Chalystha Yie Qin Lee: Epithelial 5HT4 receptor in mood, gastrointestinal motility, and visceral pain

Reposted by MargolisLab

NYU Pain Research Center @nyupainresearch.bsky.social · May 30

Happening Now! The 5th Annual Molecular Pathobiology Innovative Research Symposium is in full swing! Dazzling presentations 🎬 by the brilliant minds of Maria Fernanda, Zhiting Gong, and Chalystha Yie Qin Lee. Shoutout to Jean-Pierre N. Saint-Jeannet, PhD, for inspiring opening remarks. Stay tuned!

2 1 7

Reposted by MargolisLab

NYU Pain Research Center @nyupainresearch.bsky.social · May 30

🚨Sound the alarm- it’s an AMPIRS photo dump! 🚨Poster Session 1 brought the heat 🔥 Big shoutout to our amazing PRC members who rocked their posters! #NYUDental #nyuniversity #AMPIRS #Painresearchcenter

1 2 6

Reposted by MargolisLab

NYU Pain Research Center @nyupainresearch.bsky.social · May 30

Shoutout to our PRC pros who rocked the Flash Talk! Titles listed below🎤mic drops all around!
Sarah Najjar: Sex differences in gut serotonergic signaling of visceral pain
Badr Sokrat: Compartmentalized intracellular signaling of the prostaglandin EP4 receptor contributes to pain

Reposted by MargolisLab

NYU Pain Research Center @nyupainresearch.bsky.social · May 30

🎤 BLINK AND YOU'LL MISS IT: FLASH TALKS AT THE 5TH ANNUAL AMPIRS! ⚡ This year’s Flash Talks were a whirlwind of brilliance 🎤one mic, infinite insight. And WOW, did our presenters deliver! 👏PRC representing! #PRCpride #violetpride #NYUDental #nyuniversity

3 2 8

Reposted by MargolisLab

NYU Pain Research Center @nyupainresearch.bsky.social · May 31

Lin Hung- Early Life Stress leads to dysregulated serotonin development in the gut and predisposes to intestinal pain/dysmotility later life
Andres Cabezas- Structural studies of a mechanosensing ion channel in a native-like environment
Emmanuel Flores- Vasopressin V2 receptor activity at lysosomes