banner
mariapalumbieri.bsky.social
Maria Dilia Palumbieri
@mariapalumbieri.bsky.social
46 followers 64 following 5 posts
Passionate about science. Interested in DNA repair and ADP ribosylation Postdoc at the MaxPlanck for biology of ageing @maticlab.bsky.social
Posts Media Videos Starter Packs
Pinned
mariapalumbieri.bsky.social
Maria Dilia Palumbieri @mariapalumbieri.bsky.social · Jul 10
Thrilled to share my first first-author postdoc publication — a team effort with @aklvnbch.bsky.social. We present the first MS-based evidence of ADP-ribosylation–linked ubiquitin (ADPrUb) in cells after DNA damage.
Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb
maticlab.bsky.social
The Matić Lab @maticlab.bsky.social · Jul 9
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
3 6
mariapalumbieri.bsky.social
Maria Dilia Palumbieri @mariapalumbieri.bsky.social · 15d
Great to see research on ADPrUb, including our work, being highlighted and summarized here:
maticlab.bsky.social
The Matić Lab @maticlab.bsky.social · 20d
Superb News&Views on our recent paper reporting identification of ADP-ribosyl-linked serine ubiquitylation
www.nature.com/articles/s41...
ADPr gets a ubiquitin upgrade - Nature Chemical Biology
MARUbylation is a hybrid post-translational protein modification in which mono-ADP-ribosylation acts as a scaffold for sequential mono- and polyubiquitylation. Recent studies illuminate its substrates...
www.nature.com
mariapalumbieri.bsky.social
Maria Dilia Palumbieri @mariapalumbieri.bsky.social · 15d
ADPr gets a ubiquitin upgrade:
great to see research on ADPrUb, including our work, being highlighted and summarized here:
doi.org/10.1038/s415...
2
Reposted by Maria Dilia Palumbieri
mpiage.bsky.social
MPI for Biology of Ageing @mpiage.bsky.social · Jul 24
New Video: "Combining Cancer Drugs to Extend Lifespan" 📹

Watch our new video to learn how researchers at the Max Planck Institute for Biology of Ageing discovered that combining Rapamycin and Trametinib significantly extends the lifespan of mice.

youtu.be/5L-k4v1TRd0
Live longer - Combination therapy with Rapamycin and Trametinib prolongs the life of mice
YouTube video by Max Planck Institute for Biology of Ageing
youtu.be
2 4
mariapalumbieri.bsky.social
Maria Dilia Palumbieri @mariapalumbieri.bsky.social · Jul 14
Congrats Chiara, @chiololab.bsky.social and team!!
Reposted by Maria Dilia Palumbieri
natchembio.nature.com
Nature Chemical Biology @natchembio.nature.com · Jul 10
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites

www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
5 12
Reposted by Maria Dilia Palumbieri
andriigorelik.bsky.social
Andrii Gorelik @andriigorelik.bsky.social · Jul 10
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
5 16
mariapalumbieri.bsky.social
Maria Dilia Palumbieri @mariapalumbieri.bsky.social · Jul 10
Thrilled to share my first first-author postdoc publication — a team effort with @aklvnbch.bsky.social. We present the first MS-based evidence of ADP-ribosylation–linked ubiquitin (ADPrUb) in cells after DNA damage.
Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb
maticlab.bsky.social
The Matić Lab @maticlab.bsky.social · Jul 9
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
3 6
Reposted by Maria Dilia Palumbieri
aklvnbch.bsky.social
Andreas Kolvenbach @aklvnbch.bsky.social · Jul 9
Really happy that our paper is finally released. We show that PARP1 and histones are targets of ADP-ribosyl-linked ubiquitylation during DNA damage and describe how to detect the dual modification. Great teamwork with @mariapalumbieri.bsky.social & thanks to everyone involved @maticlab.bsky.social !
maticlab.bsky.social
The Matić Lab @maticlab.bsky.social · Jul 9
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
1 2 5
Reposted by Maria Dilia Palumbieri
ahellab.bsky.social
ahellab.bsky.social @ahellab.bsky.social · May 24
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
'
my.corehr.com
1 23 19
mariapalumbieri.bsky.social
Maria Dilia Palumbieri @mariapalumbieri.bsky.social · May 19
Thrilled to have presented our latest work at FEBS PARP 2025! A fantastic joint effort with @aklvnbch.bsky.social . I really enjoyed sharing our results and discussing with experts in the field—looking forward to what’s next!
Many thanks to the organizers for making this great meeting possible!
1 3
Reposted by Maria Dilia Palumbieri
lopeslab.bsky.social
Lopes_Lab @lopeslab.bsky.social · May 7
Exciting PhD project available in our lab (time sensitive)! 👇
1 15 10
Reposted by Maria Dilia Palumbieri
cp-trendsbiochem.bsky.social
Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Apr 25
Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.

#ADPribosylation #ubiquitination #MARUbylation #crosstalk

authors.elsevier.com/sd/article/S...
1 5 5
Reposted by Maria Dilia Palumbieri
cga-age.bsky.social
Cologne Graduate School of Ageing Research @cga-age.bsky.social · Mar 20
🎥We're excited to share the new film about our graduate programme. Get a glimpse of our faculty & PhD students and explore your research opportunities. Join us as we dive into the world of ageing research and discover what makes the CGA truly unique.👩‍🔬🧑‍🎓 www.ageing-grad-school.de/about-us/cal...
Discover the CGA film
Get to know our people & programme
www.ageing-grad-school.de
6 13
Reposted by Maria Dilia Palumbieri
maticlab.bsky.social
The Matić Lab @maticlab.bsky.social · Feb 9
We’ve uploaded a bioRxiv preprint on new antibodies specific for poly-ADP-ribosylation (PARylation). These modular tools were developed and validated through novel applications of our Serine ADP-ribosylation-based technology. www.biorxiv.org/content/10.1...
4 4 5