Lightnews — Scholar-powered news

Oscar Marín Lab @marinlab.bsky.social · Jul 16

She is! Thanks for the fantastic comic -- it will go on the wall to make company for the one of your paper (and Clems' paper)

1 2

Oscar Marín Lab @marinlab.bsky.social · Jul 16

10/10 Here’s the paper @cellcellpress.bsky.social if you want to dig in www.cell.com/cell/fulltex... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @wellcometrust.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

www.cell.com

1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

9/10 In sum, our findings reveal a postnatal molecular switch that drives the activity-dependent maturation of parvalbumin interneurons, a critical population for cortical function. Funded by the @wellcometrust.bsky.social

1 1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

8/10 Importantly, this mechanism also allows PV interneurons to regulate their mitochondrial content and function, which may also contribute to their maturation

1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

7/10 PGC-1alpha cooperates with ERR-gamma to directly regulate the transcription of many PV-enriched genes. Incidentally, it also seems involved in repressing genes that are typically enriched in other cells, like SST interneurons

1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

6/10 How is this achieved? We discovered that PGC-1alpha regulates the expression of most genes that are typically enriched in mature PV interneurons

1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

5/10 What are the mechanisms regulating the protracted maturation of cortical interneurons? We found that this process requires neuronal activity and is mediated by the transcriptional modulator PGC-1alpha

1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

4/10 Interestingly, while PV interneurons are generated in the embryo, they are late bloomers: in humans, for example, it takes more than two years for PV interneurons to acquire their mature properties

1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

3/10 Several unique properties distinguish PV interneurons: They exert a very tight control over the output of pyramidal cells; are fast-spiking, meaning they can fire action potentials at very high frequencies; are covered by perineuronal nets, and have many mitochondria

1 1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

2/10 PV interneurons are a type of inhibitory neuron in the cortex, characterized by their expression of the calcium-binding protein parvalbumin. These neurons play a crucial role in regulating neuronal activity and are involved in #memory, sensory processing, and motor control

1 1

Oscar Marín Lab @marinlab.bsky.social · Jul 16

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

www.cell.com

3 23 53

Reposted by Oscar Marín Lab

Martijn Selten @martijnselten.bsky.social · Jul 15

🚨 New Paper Alert! 🚨

I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.

Link below 👇
www.cell.com/cell/fulltex...

@cellpress.bsky.social @marinlab.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

www.cell.com

1 5 22

Reposted by Oscar Marín Lab

Centre for Developmental Neurobiology @devneuro.bsky.social · Jun 4

We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June
@marinlab.bsky.social

www.kcl.ac.uk/jobs/116505-...

Senior Executive Assistant

www.kcl.ac.uk

1 1

Reposted by Oscar Marín Lab

Daniel Ibrahim @danielibrahim.bsky.social · May 27

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

rdcu.be

7 110 250

Reposted by Oscar Marín Lab

Denis Jabaudon @djabaudon.bsky.social · May 28

Still openings, check it out!

Denis Jabaudon @djabaudon.bsky.social · Feb 2

🧠Job Opening!🧠

We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.

Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!

1 22 15

Reposted by Oscar Marín Lab

Hetan Shah @hetanshah.bsky.social · May 28

On the value of investing in curiosity driven research - which in this case contributed to the personalised gene therapy for a rare disease
on.ft.com/45rXI50 @anjahuja.bsky.social

But it also sends a critical message about the value of fundamental and translational
scientific research. The work that led to this breakthrough, using "genetic scissors" to repair a faulty gene, began in laboratories pursuing basic science and was later adapted for therapeutic use. If we are to safeguard the breakthroughs of the future, governments must recognise and protect the pipelines that lead from curiosity-driven investigation to real-world benefit.

2 15 55

Reposted by Oscar Marín Lab

Raticos de Ciencia @raticosdeciencia.bsky.social · May 11

🎙️[49] ENTENDER EL CEREBRO PARA REGULARLO
👨‍🔬 con #OscarMarínParra
@MarinLab

Alteraciones durante el desarrollo de nuestro🧠 pueden ser la causa de desordenes psiquiátricos como #autismo, #epilepsia, #bipolaridad o #esquizofrenia

#Neurociencias
(1/3)

1 1 2

Oscar Marín Lab @marinlab.bsky.social · May 20

Yeah, don’t forget the inferior colliculus

1 1

Reposted by Oscar Marín Lab

Cedric Boeckx @cedricboeckx.bsky.social · May 15

Great @nature.com paper on the early stages of human cortical development, led by @qianxuyu.bsky.social from C. Walsh’s lab, in collaboration with @drmingyaoli.bsky.social
A wonderful new resource to probe area & layer specification 🧪🧠🧬

5 8

Reposted by Oscar Marín Lab

Debby Silver @debbysilver.bsky.social · May 14

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

www.nature.com

19 68 170

Reposted by Oscar Marín Lab

Oscar Marín Lab @marinlab.bsky.social · Apr 30

1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu

3 19 64

Reposted by Oscar Marín Lab

James Briscoe @jamesbriscoe.bsky.social · May 7

Meet the 2025 @dev-journal.bsky.social Pathway to Independence (PI) fellows

Eight developmental and stem cell biologists transitioning from postdoc to principal investigator

journals.biologists.com/dev/pages/pi...

PI Fellows 2025 | Development | The Company of Biologists

PI Fellows 2025 | Development | The Company of Biologists .align{ margin-right: 10px; margin-left: 0px; } .left { float: left; width: 15%; } .right {...

journals.biologists.com

21 54

Oscar Marín Lab @marinlab.bsky.social · May 7

That’s brilliant — congrats!

1 1

Oscar Marín Lab @marinlab.bsky.social · Apr 30

10/10 Here’s the paper @nature.com if you want to dig in www.nature.com/articles/s41... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @erc.europa.eu

www.nature.com

2 9

Oscar Marín Lab @marinlab.bsky.social · Apr 30

9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @erc.europa.eu and Rosetrees Trust

1 1 2