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Reposted by Martijn Selten

Alessandro Gozzi @gozziale.bsky.social · 28d

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n

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Martijn Selten @martijnselten.bsky.social · Jul 23

Very nice comic, as always!

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Reposted by Martijn Selten

Fong Kuan Wong @brainotopia.bsky.social · Jul 16

Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors.

@martijnselten.bsky.social @clembrnrd.bsky.social

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Martijn Selten @martijnselten.bsky.social · Jul 17

Haha, this is fantastic!

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Institute of Psychiatry, Psychology & Neuroscience @kingsioppn.bsky.social · Jul 17

New research has established the molecular mechanism that drives interneurons in the cerebral cortex to mature.

The work provides clarity how cortical circuits develop and on the mechanisms behind neurodevelopmental disorders.

Click to learn more👇

bit.ly/3THw7Gb

"Molecular switch” in the brain may explain why toddlers are uncoordinated

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has established the molecular mechanism that drives interneurons in the cerebral cortex to mat...

bit.ly

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Oscar Marín Lab @marinlab.bsky.social · Jul 16

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

www.cell.com

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Martijn Selten @martijnselten.bsky.social · Jul 15

🚨 New Paper Alert! 🚨

I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.

Link below 👇
www.cell.com/cell/fulltex...

@cellpress.bsky.social @marinlab.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

www.cell.com

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Martijn Selten @martijnselten.bsky.social · Jul 15

Congratulations!!!

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Poirazi Lab @dendritesgr.bsky.social · Jul 3

📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations!

www.sciencedirect.com/science/arti...

Distinct dendritic integration strategies control dynamics of inhibition in the neocortex

Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We fo…

www.sciencedirect.com

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Centre for Developmental Neurobiology @devneuro.bsky.social · Jul 3

Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...

For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jun 15

Fos labels a distinct excitatory neuron ensemble for memory retrieval https://www.biorxiv.org/content/10.1101/2025.06.14.659414v1

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Martijn Selten @martijnselten.bsky.social · Jun 11

A very nice read!

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Zeynep Okur @zeynepokur.bsky.social · Jun 11

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation

Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

www.sciencedirect.com

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Wei Wen🫩 @wwenneuro.bsky.social · May 31

Very happy that this work is finally out in ‪@pnas.org‬! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...

Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS

Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to stabilize key features of network activity, but whether these di...

www.pnas.org

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Friedemann Zenke @fzenke.bsky.social · May 27

1/6 Why does the brain maintain such precise excitatory-inhibitory balance?
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social

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Centre for Developmental Neurobiology @devneuro.bsky.social · May 15

New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f

Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations

Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...

rdcu.be

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Martijn Selten @martijnselten.bsky.social · May 14

Fantastic work, congratulations!

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Martijn Selten @martijnselten.bsky.social · May 14

Today I started recording these fantastic pyramidal neurons in layer 2/3 of the somatosensory cortex!

New collab with @igenescu.bsky.social.

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Reposted by Martijn Selten

Nature @nature.com · May 5

Nature research paper: Regulation of PV interneuron plasticity by neuropeptide-encoding genes.

https://go.nature.com/4lWkesG

Regulation of PV interneuron plasticity by neuropeptide-encoding genes - Nature

Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through changes in the expression of the neuropeptide-encoding genes Vgf and Scg2.

go.nature.com

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Martijn Selten @martijnselten.bsky.social · May 3

Thank you Amélie!

Martijn Selten @martijnselten.bsky.social · May 2

Thanks Max!

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Martijn Selten @martijnselten.bsky.social · Apr 30

Thanks Clem - It was great working on this together!

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Martijn Selten @martijnselten.bsky.social · Apr 30

Thanks Fong!

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Martijn Selten @martijnselten.bsky.social · Apr 30

🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....

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Clem Bernard @clembrnrd.bsky.social · Apr 25

I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀

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