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Fong Kuan Wong

@brainotopia.bsky.social

97 followers 180 following 11 posts

Brain development enthusiast 🧠 @ University of Manchester fongkuanwonglab.com

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Fong Kuan Wong @brainotopia.bsky.social · Feb 19

Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development!

As per tradition here is a graphical summary of our paper in comic form.

www.science.org/doi/10.1126/...

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Fong Kuan Wong @brainotopia.bsky.social · Sep 8

It was a pleasure writing this Perspective of our work. If you are interested in learning more about activity-dependent regulation of cortical cell numbers, do have a read.

tinyurl.com/4ede4jyb

Drawing of a pyramidal cell, interneuron and microglia in a Polaroid.

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Reposted by Fong Kuan Wong

Society for Developmental Biology @socdevbio.bsky.social · Aug 13

✨ Are you a pre-tenure faculty or advanced postdoc with an academic offer in hand? 🎓 Two weeks left to apply for the SDB New Faculty Boot Camp! 🚀 Deadline: Aug 22, 2025 Apply here 👉 tinyurl.com/SDBFaculty

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Fong Kuan Wong @brainotopia.bsky.social · Aug 7

😂 This is iconic....

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Fong Kuan Wong @brainotopia.bsky.social · Jul 16

Thanks Ioana!

Fong Kuan Wong @brainotopia.bsky.social · Jul 16

Might need some new wall space for all future papers. :) Congrats once again!

Fong Kuan Wong @brainotopia.bsky.social · Jul 16

Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors.

@martijnselten.bsky.social @clembrnrd.bsky.social

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Grubb Lab @grubblabneuro.bsky.social · Jul 14

The paper is out in journal format at EJN! We thank the reviewers for their insightful comments, and how they shaped the final form of this story. Check it out here: onlinelibrary.wiley.com/doi/10.1111/...

As usual, it's open access! We're getting the data ready for sharing very soon 👀🧠🧪

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Christian Mayer @chr-mayer.bsky.social · Jul 8

Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
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Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience

Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...

www.nature.com

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Reposted by Fong Kuan Wong

Centre for Developmental Neurobiology @devneuro.bsky.social · Jul 3

Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...

For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy

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Reposted by Fong Kuan Wong

Nicholas Clifton @nicl2.bsky.social · Jun 12

New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...

Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation

AbstractBackground and Hypothesis. SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1

doi.org

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Reposted by Fong Kuan Wong

Gord Fishell @gordfishell.bsky.social · May 21

Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it!
urldefense.proofpoint.com/v2/url?u=htt...

urldefense.proofpoint.com

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Stein Aerts @steinaerts.bsky.social · May 21

One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...

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Shane Herbert @shaneherbert.bsky.social · May 6

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

www.science.org

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Fong Kuan Wong @brainotopia.bsky.social · Apr 30

Woohoo! So happy to see this out in the wild! Massive congratulations @martijnselten.bsky.social @clembrnrd.bsky.social @marinlab.bsky.social and all the other co-authors.

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Martijn Selten @martijnselten.bsky.social · Apr 30

🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....

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Doug Dyer @douglaspdyer.bsky.social · Apr 28

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

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Clem Bernard @clembrnrd.bsky.social · Apr 25

I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀

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Clem Bernard @clembrnrd.bsky.social · Apr 17

Job alert 🚨 We are hiring a research assistant!

This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.

Please spread the word!

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mareikealbert.bsky.social @mareikealbert.bsky.social · Mar 28

⏳🧠 Developmental timing is key during neocortex development. Our new review with @takashi-namba.bsky.social lab discusses the role of epigenetic and metabolic regulation of developmental timing in neocortex evolution.

www.sciencedirect.com/science/arti...

Epigenetic and metabolic regulation of developmental timing in neocortex evolution

The human brain is characterized by impressive cognitive abilities. The neocortex is the seat of higher cognition, and neocortex expansion is a hallma…

www.sciencedirect.com

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Reposted by Fong Kuan Wong

Allen Institute @alleninstitute.org · Mar 25

Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. 🧠📈

In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.

Integrating multimodal data to understand cortical circuit architecture and function - Nature Neuroscience

This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architectu...

www.nature.com

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Sally Lowell @cellysally.bsky.social · Mar 17

I absolutely love this beginners guide to scientific conferences by @jens-cells.bsky.social. It's not only useful for beginners either- there is lots of great advice even for those of us who have been attending conferences since the last millenium.

thenode.biologists.com/the-beginner...

the-beginners-guide-to-scientific-conferences

The Beginners Guide to Scientific Conferences

thenode.biologists.com

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Fong Kuan Wong @brainotopia.bsky.social · Mar 10

We are showcasing our love for developmental biology for British Science Week this year with the different model organisms that we use in our division. 🪰🐸🐟🐣🐭🧠🔬🧬🧫

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Hilary Ashe @hilaryashe.bsky.social · Mar 5

Fun paper celebrations across the developmental biology and @mcf-uom.bsky.social groupings this afternoon. Celebrating our latest paper and papers from the @brainotopia.bsky.social @lovegrovelab.bsky.social, Herbert, Manning, Bennett and Papalopulu labs. Congrats to all!

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MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Mar 4

Are you an undergraduate student considering a career in academic research?
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...

Student Placement Scheme
Research internships available for undergraduate students
Apply by 30 March 2025

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