Doug Dyer
@douglaspdyer.bsky.social
1.1K followers 500 following 64 posts
Immune cell recruitment, glycocalyx, chemokines and extracellular matrix at the Manchester Centre for Cell Matrix research and Lydia Becker Institute for Immunology he/him https://www.wellcome-matrix.org/people/doug-dyer/ #glycotime
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douglaspdyer.bsky.social
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
Reposted by Doug Dyer
profjudiallen.bsky.social
Become part of our new MRC Centre, working across Manchester and Oxford to solve a major challenge of our time - how does the immune system become dysregulated by environmental exposures to cause chronic disease.
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social
www.bmh.manchester.ac.uk
Reposted by Doug Dyer
johanduchene.bsky.social
⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?

Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk

Tested by @ycharos.bsky.social & @oga-community.bsky.social
OGA - Only Good Antibodies Community
onlygoodantibodies.co.uk
Reposted by Doug Dyer
megtriesscience.bsky.social
REGISTRATION FOR THE 2026 PROTEOGLYCANS GRS + GRC IS NOW OPEN! 🦠 (….and there’s a discount 😍)

Join us next summer for the GRS on Proteoglycans! We’re so excited to welcome our early career researchers that we’re giving the first 20 sign-ups a bursary towards their travel 🧵⬇️
Reposted by Doug Dyer
drtesutherland.bsky.social
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
douglaspdyer.bsky.social
We now have a very exciting technician post advertised as part of our long term Wellcome Trust funded team investigating the role of the glycocalyx during CNS inflammation. Supporint the lab, developing glycan analysis and research experience www.jobs.manchester.ac.uk/Job/JobDetai...
Research Technician in the Glyco-immunology (Dyer) Lab:Oxford Road
Include: background, duties, essential skills and experience, length of contract, full or part-time. Keep to 150 words.
www.jobs.manchester.ac.uk
douglaspdyer.bsky.social
Excellent but slightly sad to see this one out, my last contribution as a Postdoc to the Handel lab is in here, congrats to the main people on it!! More of evidence and mechanism of chemokine specificity! www.jbc.org/article/S002...
www.jbc.org
Reposted by Doug Dyer
labliston.bsky.social
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
Reposted by Doug Dyer
drtesutherland.bsky.social
Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...
Lecturer in Neuroimmunology, Medicine, Medical Sciences & Nutrition (MED243A) | The University of Aberdeen
Browse and apply for current job openings at the University of Aberdeen across various schools, departments and roles, including admin and academic.
www.abdn.ac.uk
Reposted by Doug Dyer
megtriesscience.bsky.social
Great opportunity available in my PhD lab! An exciting project with a really fun and supportive team 🦠
douglaspdyer.bsky.social
Please get in touch if interested, always happy to discuss interests!
Reposted by Doug Dyer
labliston.bsky.social
🧵How to write and manage your first research budgets

The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
douglaspdyer.bsky.social
Exciting to see where it goes and make sure glycans stay at the forefront!!
Reposted by Doug Dyer
merrylabnotts.bsky.social
It was a great day! @nabalabuic.bsky.social @douglaspdyer.bsky.social @wellcometrust.bsky.social A great chance for a discussion about how we bring together all our specialities to build a useful matrix atlas - and what that should look like. Matrix assemble!
Reposted by Doug Dyer
reisesousalab.bsky.social
My "Crash Course in …Immunology" is now posted on YouTube youtu.be/nBC9vvlTxF8. Taken from a public lecture @crick.ac.uk on history and basic concepts in immunity. Aimed at the lay public and those seeking an introductory overview.
The Past, Present and Future of Immunology Research – with Caetano Reis e Sousa
YouTube video by Francis Crick Institute
youtu.be
Reposted by Doug Dyer
sheencr.bsky.social
I thought it might be helpful to do a more general immunology explainer which I can then build on for example when I discuss specific papers or political actions. Do let me know if its useful and other topics if so. This first one is a general one about how we tackle infections... 🧪 #ImmunoSky
Fundamental immunology 101: the basics of an immune response
Tackling infections
open.substack.com
douglaspdyer.bsky.social
Really interesting article just odd being framed in the context of London! Not everything has to be referenced like that…
Reposted by Doug Dyer
sheencr.bsky.social
So excited to FINALLY be able to share exciting news from @lydiabeckeriii.bsky.social on our newly awarded MRC Centre of Research Excellence (MRC CoRE) in Exposome Immunology #ImmunoSky 🧪 🧵