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Centre for Developmental Neurobiology @devneuro.bsky.social · 6d

Our Neureka! Seminar Series is back 🧠

We’re very pleased to welcome Professor Nicky Clayton from the University of Cambridge, who will be presenting the first seminar of the academic year, hosted by Alexi Mery.

Join us at 1pm today in the Large Meeting Room to hear about her exciting research!

Centre for Developmental Neurobiology @devneuro.bsky.social · 9d

www.linkedin.com/posts/vitae_...

#vitaecon2025 | Vitae

Congratulations to the winners of the Vitae Impact, Culture and Engagement (ICE) Awards 2025! ⭐ The awards ceremony was held on the evening of Day 1 of the in-person element of #VitaeCon2025, thank ...

www.linkedin.com

Centre for Developmental Neurobiology @devneuro.bsky.social · 9d

Huge congratulations to Dr. Leigh Wilson who recently won the award for Innovative and Inclusive Practice at the @vitae-news.bsky.social Impact, Culture and Engagement Awards! 🎉

@devneuroacademy.bsky.social
@devneuro.bsky.social
@kingsioppn.bsky.social

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Centre for Developmental Neurobiology @devneuro.bsky.social · Sep 3

We're very pleased to welcome Professor Thomas Reh from the University of Washington, who is visiting the CDN to present an external seminar hosted by Professor Benedikt Berninger.

Join us at 1pm today in the Large Meeting Room to hear all about his exciting research!

Centre for Developmental Neurobiology @devneuro.bsky.social · Jul 18

We’re delighted to welcome Prof. Dimphna Meijer from the Delft University of Technology, who will be presenting an external seminar today, hosted by Prof. Robert Hindges.

Join us at 1pm in the Large Meeting Room to hear her talk!

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Jul 16

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

www.cell.com

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Reposted by Centre for Developmental Neurobiology

Dev Neuro Academy @devneuroacademy.bsky.social · Jul 11

Sneak peek of the exhibition happening today👀🤞

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Reposted by Centre for Developmental Neurobiology

Dev Neuro Academy @devneuroacademy.bsky.social · Jul 11

Happy Friday and Day 4 of DNA CREATE!!!

Today the students will be presenting their projects at the Science Gallery 🖼️🥼

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Reposted by Centre for Developmental Neurobiology

Dev Neuro Academy @devneuroacademy.bsky.social · Jul 10

Day 3 has been busy, busy, busy!!!

Students are focused working on their group projects! Excited for the exhibition tomorrow

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Reposted by Centre for Developmental Neurobiology

Dev Neuro Academy @devneuroacademy.bsky.social · Jul 8

Day 1 of DNA CREATE is off to a great start!

We started the morning with some introductions, ice breakers and reflection as we created our own self portraits🙌

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Reposted by Centre for Developmental Neurobiology

Dev Neuro Academy @devneuroacademy.bsky.social · Jul 9

Good morning and happy Wednesday from the DNA Create team!

Today’s morning session is all about brains (literally) 🧠

Our students are diving into neuroanatomy and getting a firsthand look at neuroscience research, thanks to our incredible researchers at @devneuro.bsky.social 🤞🤞🤞

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Centre for Developmental Neurobiology @devneuro.bsky.social · Jul 3

Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...

For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy

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Centre for Developmental Neurobiology @devneuro.bsky.social · Jun 19

We're #hiring! We're looking for an experienced and dynamic Research Strategy Manager to join our vibrant Centre. More details in link. Deadline 09 July
www.kcl.ac.uk/jobs/118025-...

Research Strategy Manager

www.kcl.ac.uk

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Centre for Developmental Neurobiology @devneuro.bsky.social · Jun 4

We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June
@marinlab.bsky.social

www.kcl.ac.uk/jobs/116505-...

Senior Executive Assistant

www.kcl.ac.uk

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Centre for Developmental Neurobiology @devneuro.bsky.social · May 15

New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f

Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations

Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...

rdcu.be

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Reposted by Centre for Developmental Neurobiology

Corinne Houart @cohouart.bsky.social · May 8

@houartlab.bsky.social first time at the comparative neuro conference. Fantastic #ECCN2025 meeting! The mix of ‘old’ and new technologies brings the field a new edge and the potential for new understanding of brain evolutionary mechanisms. Exciting!

Roberto Toro @r3rt0.bsky.social · May 6

Differences in neurogenesis across species appear since the earliest stages of development, as shows @cohouart.bsky.social
#ECCN2025 @borrell-lab.bsky.social @k4tj4.bsky.social

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Reposted by Centre for Developmental Neurobiology

Corinne Houart @cohouart.bsky.social · May 8

Dkk genes dynamically expressed in the zebrafish nervous system, some in very discreet brain populations (watch this space for brain images).
Malik Missaoui is using genetics to follow behaviour of endogenous proteins and crack their local functions.
@mrc-cndd.bsky.social @kingsioppn.bsky.social

Houart Lab @houartlab.bsky.social · May 6

🎣 Fishing for Dkk in #zebrafish 🎣

In the lab, PhD student Malik Misssaoui looks for the expression patterns of the dkk genes in zebrafish. Dkk proteins are modulators of wnt singalling, and changes in their expression levels have been linked to neurodegenerative diseases like Alzheimers.

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Apr 30

10/10 Here’s the paper @nature.com if you want to dig in www.nature.com/articles/s41... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @erc.europa.eu

www.nature.com

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Apr 30

9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @erc.europa.eu and Rosetrees Trust

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Apr 30

8/10 Importantly, this mechanism also regulates the connectivity of PV interneurons during learning, for example, in a fear-conditioning paradigm

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Apr 30

7/10 For PV interneurons, Vgf is the critical gene modulating the plasticity of inhibitory inputs received from other PV interneurons

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Apr 30

6/10 Incidentally, the Greenberg lab described a few years ago that hippocampal pyramidal cells use Scg2 to modulate the inhibition they receive from PV and CCK interneurons. You can find their paper here www.nature.com/articles/s41...

Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network - Nature

Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the role...

www.nature.com

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Apr 30

5/10 How is this achieved? We found that PV interneurons induce the expression of two genes encoding multiple neuropeptides, Scg2 and Vgf, in response to increased activity

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Apr 30

4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity

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Reposted by Centre for Developmental Neurobiology

Oscar Marín Lab @marinlab.bsky.social · Apr 30

3/10 Neuronal activity operates within a tightly controlled range for the optimal functioning of #brain circuits. When synaptic connectivity and network activity are modified, such as when we are learning, compensatory mechanisms are needed to maintain stability

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