@martinneurosci40.bsky.social
Reposted
Ish's outstanding work entitled: "Persistent changes in the dorsal root ganglion nociceptor translatome governs hyperalgesic priming in mice: roles of GPR88 and Meteorin" is now online in PAIN
journals.lww.com/pain/fulltex...
journals.lww.com/pain/fulltex...
Persistent changes in the dorsal root ganglion nociceptor... : PAIN
. We hypothesized that hyperalgesic priming occurs because of reorganization of translation of mRNA in nociceptors. To test this hypothesis, we used paclitaxel treatment as the priming stimulus and tr...
journals.lww.com
January 29, 2025 at 3:24 PM
Ish's outstanding work entitled: "Persistent changes in the dorsal root ganglion nociceptor translatome governs hyperalgesic priming in mice: roles of GPR88 and Meteorin" is now online in PAIN
journals.lww.com/pain/fulltex...
journals.lww.com/pain/fulltex...
Reposted
Very neat paper from Andy Bellemer's lab at App State doing a screen for RNA binding proteins in flies to find mediators of thermal nociception pmc.ncbi.nlm.nih.gov/articles/PMC... key takeaway for me is that regulators of translation are the top hits (including some already known)...
A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception
Nociception is the process by which sensory neurons detect and encode potentially harmful environmental stimuli to generate behavioral responses. Nociceptor neurons exhibit plasticity in which their s...
pmc.ncbi.nlm.nih.gov
January 29, 2025 at 8:38 PM
Very neat paper from Andy Bellemer's lab at App State doing a screen for RNA binding proteins in flies to find mediators of thermal nociception pmc.ncbi.nlm.nih.gov/articles/PMC... key takeaway for me is that regulators of translation are the top hits (including some already known)...
Reposted
Excellent review from @khannalabuf.bsky.social and his team published in Neurobiology of Pain!
Interested in clock genes and pain? ⏰🧠 Curious how your body’s internal timekeepers might tattle on pain pathways?
#Chronobiology #PainScience
The contribution of clock genes BMAL1 and PER2 in osteoarthritis-assoc... www.sciencedirect.com/science/arti...
#Chronobiology #PainScience
The contribution of clock genes BMAL1 and PER2 in osteoarthritis-assoc... www.sciencedirect.com/science/arti...
The contribution of clock genes BMAL1 and PER2 in osteoarthritis-associated pain
Joint pain is the primary symptom of osteoarthritis (OA) and the main motivator for patients to seek medical care. OA-related pain significantly restr…
www.sciencedirect.com
January 6, 2025 at 2:09 PM
Excellent review from @khannalabuf.bsky.social and his team published in Neurobiology of Pain!
Reposted
Happy to share the fully reviewed and revised version of our recent study, where we focus on recurrent mutations in cleavage and polyadenylation sites in tumor suppressor genes. Huge congrats to @ykainov.bsky.social and Fursham Hamid!
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals
Somatic mutations frequently disrupt cleavage and polyadenylation signals in tumour suppressor genes in human cancers, likely contributing to tumour progression.
doi.org
December 12, 2024 at 3:09 PM
Happy to share the fully reviewed and revised version of our recent study, where we focus on recurrent mutations in cleavage and polyadenylation sites in tumor suppressor genes. Huge congrats to @ykainov.bsky.social and Fursham Hamid!
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
Reposted
Delighted to write for the Times Education Supplement.
Timms: Could a focus on spatial reasoning improve maths scores?
www.tes.com/magazine/tea...
For more: www.surrey.ac.uk/spatial-reas...
Timms: Could a focus on spatial reasoning improve maths scores?
www.tes.com/magazine/tea...
For more: www.surrey.ac.uk/spatial-reas...
Timss: could a focus on spatial reasoning improve maths scores?
The latest Timss international rankings show English pupils' weakness in key areas of maths – and our lack of focus on spatial reasoning is a major factor, argues Emily Farran
www.tes.com
December 8, 2024 at 7:23 PM
Delighted to write for the Times Education Supplement.
Timms: Could a focus on spatial reasoning improve maths scores?
www.tes.com/magazine/tea...
For more: www.surrey.ac.uk/spatial-reas...
Timms: Could a focus on spatial reasoning improve maths scores?
www.tes.com/magazine/tea...
For more: www.surrey.ac.uk/spatial-reas...
Reposted
This one is also for #PainResearch & @alexmsalmeida.bsky.social
NEW in #NatureReviewsGastroHep!
This Review on gut-brain axis & pain signalling in the gut
By Kim Meerschaert & Isaac Chiu
www.nature.com/articles/s41...
🔓 rdcu.be/d1dFo
🧪 #gastrosky #GIsky
This Review on gut-brain axis & pain signalling in the gut
By Kim Meerschaert & Isaac Chiu
www.nature.com/articles/s41...
🔓 rdcu.be/d1dFo
🧪 #gastrosky #GIsky
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract - Nature Reviews Gastroenterology & Hepatology
Visceral pain is a major clinical issue, most commonly associated with gastrointestinal disorders. This Review discusses molecular mechanisms by which neurons are sensitized in the gut, outlining sign...
www.nature.com
November 23, 2024 at 2:39 PM
This one is also for #PainResearch & @alexmsalmeida.bsky.social
Reposted
Attentional failures after sleep deprivation represent moments of cerebrospinal fluid flow https://www.biorxiv.org/content/10.1101/2024.11.15.623271v1
Attentional failures after sleep deprivation represent moments of cerebrospinal fluid flow https://www.biorxiv.org/content/10.1101/2024.11.15.623271v1
Sleep deprivation rapidly disrupts cognitive function, and in the long term contributes to neurologi
www.biorxiv.org
November 15, 2024 at 10:17 PM
Attentional failures after sleep deprivation represent moments of cerebrospinal fluid flow https://www.biorxiv.org/content/10.1101/2024.11.15.623271v1
Reposted
KDM2B is required for ribosome biogenesis and its depletion unequally affects mRNA translation https://www.biorxiv.org/content/10.1101/2024.05.22.595403v1
KDM2B is required for ribosome biogenesis and its depletion unequally affects mRNA translation https://www.biorxiv.org/content/10.1101/2024.05.22.595403v1
KDM2B is a JmjC domain lysine demethylase, which promotes cell immortalization, stem cell self-renew
www.biorxiv.org
May 23, 2024 at 2:04 PM
KDM2B is required for ribosome biogenesis and its depletion unequally affects mRNA translation https://www.biorxiv.org/content/10.1101/2024.05.22.595403v1
Reposted
1/3
knowledge of the underlying molecular mechanisms remains limited.
Here, we show that
➡️ RNA G-quadruplexes (RG4s)
regulate mitochondrial function by modulating cytoplasmic
➡️ mRNA translation of nuclear-encoded mitochondrial proteins.
knowledge of the underlying molecular mechanisms remains limited.
Here, we show that
➡️ RNA G-quadruplexes (RG4s)
regulate mitochondrial function by modulating cytoplasmic
➡️ mRNA translation of nuclear-encoded mitochondrial proteins.
April 15, 2024 at 1:20 PM
1/3
knowledge of the underlying molecular mechanisms remains limited.
Here, we show that
➡️ RNA G-quadruplexes (RG4s)
regulate mitochondrial function by modulating cytoplasmic
➡️ mRNA translation of nuclear-encoded mitochondrial proteins.
knowledge of the underlying molecular mechanisms remains limited.
Here, we show that
➡️ RNA G-quadruplexes (RG4s)
regulate mitochondrial function by modulating cytoplasmic
➡️ mRNA translation of nuclear-encoded mitochondrial proteins.
Reposted
Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation https://www.biorxiv.org/content/10.1101/2023.11.22.568289v1
Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation https://www.biorxiv.org/content/10.1101/2023.11.22.568289v1
Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent w
www.biorxiv.org
November 23, 2023 at 2:31 AM
Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation https://www.biorxiv.org/content/10.1101/2023.11.22.568289v1