Fred Ramsdell was parked at a campground in Montana on Monday when his wife suddenly started shouting. He first thought that maybe she had seen a grizzly bear. Instead, she had regained cell service and had seen a flood of text messages with the same news. “You just won the Nobel Prize!” she yelled.

Neuropixels Ultra!

By @steinmetzneuro.bsky.social, who led a big collaboration

www.sciencedirect.com/science/arti...

100%

Congratulations!!

How does the brain decide? 🧠

Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.

After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.

rdcu.be/eGUrv

In neuroscience, we often try to understand systems by analyzing their representations — using tools like regression or RSA. But are these analyses biased towards discovering a subset of what a system represents? If you're interested in this question, check out our new commentary! Thread:

attractors are the new receptive fields

🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds.
pip install and play around with our toy dataset:
🔗 github.com/Julie-Fabre/...

Here’s the programme: parisneuro.ovh/program/

I really recommend sending your students to the Paris Spring School, many imaging and ephys techniques are covered in pretty good depth and the atmosphere is consistently fantastic every year! And in such a setting! parisneuro.ovh

we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team.

publicusaresearchbenefits.com

please share and re-share so we get more great stories in there!

🔊New resource: Bombcell, automated quality control for extracellular electrophysiology
💡This is an #opensource, user-friendly toolbox that streamlines quality control for spike sorting outputs.
👩‍🔬Develop by Julie M. J. Fabre
🔗Link: open-neuroscience.com/en/post/bomb...
#OpenScience #Neuroscience

Thrilled to share our state-of-the-art method for in vivo cell-type classification and brain region localization, NEMO, which is now now a spotlight at @iclr-conf.bsky.social !

We use NEMO to characterize the electrophysiological diversity of cell-types across the entire mouse brain. 🐭 🧪 🧠

Two UCL researchers, including Dr Julie Fabre (@uclqsion.bsky.social) have been named as Schmidt Science Fellows, an award given to 32 exceptional early career researchers worldwide.
Congratulations to both Dr @juliefabre.bsky.social & Dr Almarri on this incredible achievement! 👏

How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later?

Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala.

📄: nature.com/articles/s41...

Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D!

Suite3D: Volumetric cell detection for two-photon microscopy
by @haydari.bsky.social & team.
www.biorxiv.org/content/10.1...

First off, Bombcell is a MATLAB package (python version coming) developed by @juliefabre.bsky.social. It uses several metrics, like waveform shape, spike amplitudes and drift, to determine whether a detected unit is noise, multi-unit activity, axonal or a single neuron.
github.com/Julie-Fabre/...

It was an honour, thank you @rezashadmehr.bsky.social for organizing this great seminar series!

Talk link: m.youtube.com/watch?v=zy0v...

Congrats!!

1/7 Our paper on individual variability in decision-making is finally out in @nature.com! Inspired by the classic work by Mante and Sussillo, we trained many rats to solve context-dependent decision-making, and we found that different brains use different neural mechanisms to solve the same task!

control is a complimentary approach to alignment.

its really sensible, practical and can be done now, even before systems are superintelligent.

youtu.be/6Unxqr50Kqg?...

The International Brain Laboratory reproducibility platform paper is now published at eLife. An amazing effort by many different labs and individuals to understand and improve the reproducibility of electrophysiological measurements in mice. 🧠

🚨 New paper alert! 🚨
We’ve just launched openretina, an open-source framework for collaborative retina modeling across datasets and species.
A 🧵👇 (1/9)

Standing up for science in Seattle - some lab members (Zhiwen, Nancy, Fabiola, and Jeremy) plus lab-friend Harsha @harshag.bsky.social. If only it seemed like there was the remotest chance anyone in the administration cared about our voices.