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Reposted by Maxim Igaev

Jose Jimenez-Luna @jjimenezluna.bsky.social · Jul 10

BioEmu is now on @science.org ! The revised version includes an upgraded model and makes a lot of MD simulation data internally generated at MSR available to the public. This took a lot of firepower from us in the last two years.
www.science.org/doi/10.1126/...

Scalable emulation of protein equilibrium ensembles with generative deep learning

Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that...

www.science.org

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Michal Kolář @mhko.bsky.social · Jul 9

New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring.

www.sciencedirect.com/science/arti...

A scheme of chemico-biological evolution of protein-RNA interactions. It started about 4.5 billion years ago with prebiotic monomers, went through peptides, oligonucleotides, and simple complexes, reaching proteins and RNA at about 4-3.7 billion years ago.

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Reposted by Maxim Igaev

CompBioPhys @compbiophys.bsky.social · Jul 2

📌Carter @carterjwilson.bsky.social‬ is presenting (P-2.44) "A Tale of Two #Aquaporins: Structural Mechanisms of Gating and Inhibition in Aqp3 and Aqp7" and + 📌Florian will explain (P-2.196) "How Loop #Dynamics Control Activity and Selectivity of a Short Chain #Reductase" Happy discussions! 👥

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CompBioPhys @compbiophys.bsky.social · Jul 2

Have a great D2@ #EBSA2025 in Rome🫠! Here are the posters of today's session: 📌Maksim @maksimkalutskii.bsky.social is presenting (P-2.195) his project addressing #Microtubule Dynamics Are Defined by Conformations and Stability of Clustered #Protofilaments 📜🔗 www.pnas.org/doi/10.1073/...

Microtubule dynamics are defined by conformations and stability of clustered protofilaments | PNAS

Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening, and transitions betw...

www.pnas.org

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Derivery Lab - MRC LMB @deriverylab.bsky.social · Jun 23

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

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Manuel Thery @manuelthery.bsky.social · Jun 4

the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours.
Alone you go faster, together we go further.

Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · Jun 3

Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...

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Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · Jun 3

Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...

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Reposted by Maxim Igaev

Leah @hoxinsocks.bsky.social · Jun 10

( #TubulinTuesday! )

Maxim Igaev @maxotubule.bsky.social · Jun 3

Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.

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Reposted by Maxim Igaev

Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · Jun 8

UK immigration policy is destabilising international academics’ careers. The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabu et al
www.timeshighereducation.com/opinion/uk-i...

UK immigration policy is destabilising international academics’ careers

The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabi, Fleura Bardhi and Laetitia Mimoun

www.timeshighereducation.com

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Reposted by Maxim Igaev

CompBioPhys @compbiophys.bsky.social · Jun 5

📜 Great work by Maksim and Co-authors! Congratulations to this latest #microtubule #publication in @pnas.org 🍾 @maxotubule.bsky.social @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social

Maxim Igaev @maxotubule.bsky.social · Jun 3

Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.

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Maxim Igaev @maxotubule.bsky.social · Jun 3

Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.

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Reposted by Maxim Igaev

Matthieu Chavent @matthchavent.bsky.social · May 27

Our joint paper with Wonpil Im lab is now available as a preprint:
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"

www.biorxiv.org/content/10.1...

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Maxim Igaev @maxotubule.bsky.social · Jun 3

Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.

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Maxim Igaev @maxotubule.bsky.social · Apr 14

It was a great pleasure! Thanks for hosting me 🫡

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Reposted by Maxim Igaev

Rafael C. Bernardi @rcbernardi.bsky.social · Feb 17

🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...

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irobcross.bsky.social @irobcross.bsky.social · Feb 12

Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

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Maxim Igaev @maxotubule.bsky.social · Jan 7

sorry, in Rome

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Maxim Igaev @maxotubule.bsky.social · Jan 7

EBSA 2025 in Milan (www.ebsa2025.eu)

EBSA 2025

Join the 15th EBSA Congress in Rome from June 30 to July 4, 2025! Organized by SIBPA, EBSA, and the Protein Society, with support from IUPAB, the event will take place at the Palazzo dei Congressi. Di...

www.ebsa2025.eu

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Reposted by Maxim Igaev

CompBioPhys @compbiophys.bsky.social · Jan 7

The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics

CompBioPhys @compbiophys.bsky.social · Dec 4

📢 It's our great pleasure to invite you all to our upcoming #Workshop on "Computer Simulation and #Theory of Macromolecules" in #Hünfeld on March 7-8, 2025 in #hybrid format! See you online or on-site! More details are provided here: www.mpinat.mpg.de/workshop/hue... #TheoryHünfeld2025 #biophysics

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Michal Kolář @mhko.bsky.social · Dec 14

We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to [email protected].

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Martin Vögele @martinvoegele.bsky.social · Dec 13

The inside of a cell is incredibly crowded! With advancing computing power and smart algorithms, this complex world is becoming more accessible through simulations.

This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...

#CompChem

Recent Progress in Modeling and Simulation of Biomolecular Crowding and Condensation Inside Cells

Macromolecular crowding in the cellular cytoplasm can potentially impact diffusion rates of proteins, their intrinsic structural stability, binding of proteins to their corresponding partners as well ...

pubs.acs.org

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Reposted by Maxim Igaev

Jess Ewald @ewaldlab.org · Dec 13

🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉

We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.

I am beginning the search for two postdocs now - stay tuned for more details!

ewaldlab.org

Ewald Lab

@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.

ewaldlab.org

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Max Planck Institute of Biophysics @mpibp.bsky.social · Dec 12

Do not miss our latest #cryoET work! 🕵️ Xing et al. present the dynamic architecture of TRiC in human cells! The study of this protein-folding chaperonin opens the door to understanding its dysfunction in diseases like cancer and neurodegeneration 🧠🧪 #teamTOMO @becklab.bsky.social

Chaperonin TRiC within human cells. The left panel displays a representative 3D map from a tomogram illustrating the spatial distribution of open and closed TRiC complexes in human cells. The top right panel highlights the interaction of PDCD5 with the CCT3-1-4 subunits of the open TRiC complex. The bottom right panel shows the closed TRiC complex forming clusters of two
particles.

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Jorge Ferreira @jorgeferreira.bsky.social · Nov 13

Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you.
go.bsky.app/G5cQqYT

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Kirsty Wan @micromotility.bsky.social · Nov 13

Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN

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