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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Jul 25

New preprint from MCF:
Kerrie Marie and collaborators reveal dynamic patterns of lineage state switching correlated with melanoma tumor evolution, offering insights into potential new therapeutic targets.
www.biorxiv.org/content/10.1...

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

Melanoma plasticity, driven by phenotype state switching, underlies clinically relevant traits such as metastasis and therapy resistance. As melanoma progression is thought to recapitulate aspects of ...

www.biorxiv.org

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Jul 17

We are excited to announce that Professor Graham Pavitt, Chair in Molecular Biology, has been appointed as our new Head of Division!
Join us in welcoming Graham to his new role—we look forward to the exciting times ahead!

research.manchester.ac.uk/en/persons/g...

Graham Pavitt

research.manchester.ac.uk

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Reposted by Molecular and Cellular Function, University of Manchester

Pliotas Group @pliotasgroup.bsky.social · Jul 15

In our study @elife.bsky.social we uncover the mechanism of mPPase inhibition. Over 20x structures to date are in a symmetric form. We use EPR(PELDOR/DEER) and reveal asymmetric binding at the active site while maintaining symmetric conformation at periplasmic site

elifesciences.org/reviewed-pre...

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Jul 17

Very special graduation...

Congratulations Katie and @tranejoan.bsky.social !

Joan Chang @tranejoan.bsky.social · Jul 11

Yesterday I attended the #graduation of my #firstPhD student Katie Lowles. What a moment! No longer her PI but still feeling very proud @mcf-uom.bsky.social @mcrcellmatrix.bsky.social

(Oh and I also attended my first ever #GRCCollagen...it was awesome even though I had to leave early!)

Reposted by Molecular and Cellular Function, University of Manchester

Daniela Robles-Espinoza @daniela-oaks.bsky.social · Mar 10

Super excited to host Dr Kerrie L Marie @mcf-uom.bsky.social today @liigh-unam.bsky.social! She talked to us about the embryonic pathways that are co-opted by #melanoma cells, a great talk with lots of questions 🤓

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Reposted by Molecular and Cellular Function, University of Manchester

Joan Chang @tranejoan.bsky.social · Mar 11

We're ready for #BritishScienceWeek @ManchesterMuseum! All about #secretion, #ECMatrix assembly, from cells to #zebrafish! @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

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Reposted by Molecular and Cellular Function, University of Manchester

Byron Lab @thebyronlab.bsky.social · Mar 5

Fantastic postdoc opportunities available @fbmh-uom.bsky.social!

💡 Please get in touch if you're interested in using biomaterials, cell biology, 'omics technologies and data science to investigate cell adhesion networks and gene expression in cancer

#science #research #jobs #careers

Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Mar 4

Early-career fellowships at the University of Manchester!

To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers:

www.bmh.manchester.ac.uk/research/sup...

Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester

Find out about and apply for a Bicentenary Early Career Research Fellowship.

www.bmh.manchester.ac.uk

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Mar 5

Our researchers leb by @hilaryashe.bsky.social show the versatility of the SunTag system by providing proof-of-principle data for new avenues of exploration, quantitation and visualisation of protein synthesis.
@biologists.bsky.social

journals.biologists.com/jcs/article/...

Exploiting the SunTag system to study the developmental regulation of mRNA translation

The ability to quantitatively study mRNA translation using SunTag imaging is transforming our understanding of the translation process. Here, we expand the SunTag method to study new aspects of transl...

journals.biologists.com

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Reposted by Molecular and Cellular Function, University of Manchester

Hilary Ashe @hilaryashe.bsky.social · Mar 5

Our new paper describes how SunTag imaging of mRNA translation can be used to study ribosome pausing in development. We also adapt the system to study translation of a secreted protein. Work done in collaboration with @mrattray.bsky.social and @markashe.bsky.social
doi.org/10.1242/jcs....

Exploiting the SunTag system to study the developmental regulation of mRNA translation

The ability to quantitatively study mRNA translation using SunTag imaging is transforming our understanding of the translation process. Here, we expand the SunTag method to study new aspects of transl...

doi.org

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Mar 5

A new day, a new preprint!

@tranejoan.bsky.social lab demonstrated that macrophages promote collagen deposition in fibroblasts by inducing circadian rhythms, with M2-derived PDGFA playing a key role in this process.

Read here:
www.biorxiv.org/content/10.1...

Macrophages promote collagen deposition through circadian regulation of fibroblasts

Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

www.biorxiv.org

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Reposted by Molecular and Cellular Function, University of Manchester

Joan Chang @tranejoan.bsky.social · Mar 5

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...

Macrophages promote collagen deposition through circadian regulation of fibroblasts

Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

www.biorxiv.org

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Reposted by Molecular and Cellular Function, University of Manchester

Sankari Nagarajan @sankarinagarajan.bsky.social · Mar 4

Exciting PhD opportunity available in my lab for the students from Black heritage background. Apply soon. 🤞🤞🤞
@mcr-breastcentre.bsky.social @mcf-uom.bsky.social

CRUK Black Leaders in Cancer Non-Clinical PhD Opportunity

📅 Deadline: 4 April

🔗 crukcentre.manchester.ac.uk/study/resear...

Research Opportunities - Cancer Research UK Manchester Centre

Explore the range of postgraduate cancer research opportunities available in Manchester.

crukcentre.manchester.ac.uk

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Mar 4

Early-career fellowships at the University of Manchester!

To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers:

www.bmh.manchester.ac.uk/research/sup...

Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester

Find out about and apply for a Bicentenary Early Career Research Fellowship.

www.bmh.manchester.ac.uk

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Reposted by Molecular and Cellular Function, University of Manchester

Sankari Nagarajan @sankarinagarajan.bsky.social · Mar 4

A fantastic postdoc opportunity available for talented PhD graduates to work in our CRUK funded PhD project.
jobs.manchester.ac.uk/internal/Job...
@mcr-breastcentre.bsky.social @mcrcnews.bsky.social @mcf-uom.bsky.social @mcrcellmatrix.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social

jobs.manchester.ac.uk

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Mar 4

New preprint!
@sankarinagarajan.bsky.social and colleagues employed machine learning approaches to identify critical gene pathways and transcription factor networks in breast cancer

Sankari Nagarajan @sankarinagarajan.bsky.social · Mar 4

Our lab's very first manuscript is out in BioRxiv. Hope this would be interesting for breast cancer scientists: www.biorxiv.org/content/10.1... @mcf-uom.bsky.social @mcr-breastcentre.bsky.social @mcrcnews.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social

Subtype-specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Gene expression is tightly controlled by DNA elements called enhancers by associating with lineage-specific transcription factors. These enhancers transcribe non-coding RNAs (called enhancer RNAs or e...

www.biorxiv.org

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Reposted by Molecular and Cellular Function, University of Manchester

Hilary Ashe @hilaryashe.bsky.social · Feb 24

Is there more to defining the eve stripes in the Drosophila embryo than just transcriptional regulation? We provide evidence that spatially regulated mRNA decay is also important.

Magnus Rattray @mrattray.bsky.social · Feb 14

Nice new paper from Jennifer Love and @hilaryashe.bsky.social lab members shows how mRNA decay is spatially and temporally regulated, ramping up at the edges of stripes in early drosophila embryos, with mRNAs increasingly localising to P-bodies for degradation www.biorxiv.org/content/10.1...

www.biorxiv.org

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Feb 13

New paper by @pliotasgroup.bsky.social !

Pliotas Group @pliotasgroup.bsky.social · Feb 10

In our recent article we show the YbiO mechanosensitive channel can achieve pore openings of 3nS under membrane tension equalling the largest known gated-pore MscL and we also solve a cryo- EM structure of a YbiO in a sub-open state. Great effort by @lane-b.bsky.social www.cell.com/structure/fu...

The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore

Lane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances equivalent to the largest gated-pore in nature when subjected to membrane tension. Single-channel analysis shows...

www.cell.com

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Jan 23

Welcome to Bluesky @pliotasgroup.bsky.social !

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Jan 18

Paper alert!
Pliotas Group reviewed pulsed dipolar electron paramagnetic resonance spectroscopy applications and highlighted emerging strategies for future studies

www.sciencedirect.com/science/arti...

Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling

Pulsed dipolar electron paramagnetic resonance spectroscopy (PDS), combined with site-directed spin-labelling, represents a powerful tool for the inve…

www.sciencedirect.com

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Reposted by Molecular and Cellular Function, University of Manchester

Joan Chang @tranejoan.bsky.social · Jan 16

Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻

Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.

doi.org/10.7554/eLif...
@elife.bsky.social

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...

doi.org

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Jan 18

Paper alert!
A collaborative study led by @tranejoan.bsky.social shows that circadian-regulated endocytic recycling is central to homeostatic assembly of collagen fibrils and is disrupted in diseases.
Published in @elife.bsky.social
doi.org/10.7554/eLif...

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...

doi.org

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Dec 3

Bicentenary PhD scholarship is available in @ximenasotouom.bsky.social group.
If you are enthusiastic and keen on using Zebrafish to elucidate signals and mechanisms involved in spinal cord regeneration apply!
Deadline is the 10th of January, 2025.
www.findaphd.com/phds/project...

(Bicentenary) Understanding Spinal Cord Regeneration: The Role of Dynamic Gene Expression at The University of Manchester on FindAPhD.com

PhD Project - (Bicentenary) Understanding Spinal Cord Regeneration: The Role of Dynamic Gene Expression at The University of Manchester, listed on FindAPhD.com

www.findaphd.com

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Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · Nov 21

Hello, Bluesky community!
We are the Division of Molecular and Cellular Function (MCF) in the Faculty of Biology, Medicine and Health at the University of Manchester.
Follow us for research updates and job opportunities!

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