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Reposted by Michael Honigberg

JACC Journals @jaccjournals.bsky.social · Aug 29

In this exploratory analysis, treatment with low-dose colchicine was associated with an attenuated annual clonal growth in TET2 CH. These findings suggest the potential for colchicine to curb the proliferative advantage of key CH driver mutations https://bit.ly/3HWJL5M

#ESCCongress #WCCardio #JACC

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Reposted by Michael Honigberg

JAMA Cardiology @jamacardiology.com · Aug 30

Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis.

#ESCCongress #WCCardio

ja.ma/45RBaJG

A graph titled Figure 1. Cumulative Incidence of Myocarditis and Pericarditis During Follow-Up by Clonal Hematopoiesis of Indeterminate Potential (CHIP) Status displays three lines: Large CHIP, Any CHIP, and No CHIP, charting cumulative incidence over follow-up time.

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Reposted by Michael Honigberg

Eric Topol @erictopol.bsky.social · Aug 30

New report that CHIP (clonal hematopoiesis of indeterminate potential, blood stem cell clones that increase with age) is an independent risk factor for myocarditis and pericarditis, promoting inflammation #ESC2025
@jama.com

jamanetwork.com/journals/jam...

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Michael Honigberg @mchonig.bsky.social · Aug 27

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Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.

Paper (OA): www.jacc.org/doi/10.1016/...

Editorial: www.jacc.org/doi/10.1016/...

Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!

@mghcvrc.bsky.social @broadinstitute.org

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Michael Honigberg @mchonig.bsky.social · Aug 27

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HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)

In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size

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Michael Honigberg @mchonig.bsky.social · Aug 27

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Key CHIP subtypes were associated w/ adverse CV events

Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF

👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)

Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity

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Michael Honigberg @mchonig.bsky.social · Aug 27

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We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP

Women were followed for ~10 y for coronary heart disease and several secondary outcomes

👇

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Michael Honigberg @mchonig.bsky.social · Aug 27

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CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers

We + others have shown that CHIP also associates w/ ⬆️ CVD risk

But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD

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Michael Honigberg @mchonig.bsky.social · Aug 27

The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!

jacc.org/doi/10.1016/...

Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study

👇

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Michael Honigberg @mchonig.bsky.social · Aug 21

Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs

Honigberg lab is rapidly growing 📈 👇

@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social

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Reposted by Michael Honigberg

Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · Aug 6

Now accepting applications for the 2026-2027 Women's Heart Health Program Fellowship!🫀Click here for details: massgeneral.org/heart-center...

@mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social

Women's Heart Health Fellowship Program

The Women’s Heart Health Fellowship Program at Massachusetts General Hospital provides advanced training in the prevention, diagnosis, and treatment of heart disease in women.

massgeneral.org

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Reposted by Michael Honigberg

Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · Jul 30

Registration is now open!📣We're co-hosting a patient SCAD Symposium with @scadalliance.bsky.social in October 🫀
Please click on the event page to register & for all of the details! massgeneral.org/heart-center...
@emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social

SCAD Patient Symposium: Your Heart, Your Story

Join us October 18, 2025 for a day of building community with your peers, and hearing from renowned experts about all things SCAD.

massgeneral.org

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Michael Honigberg @mchonig.bsky.social · Jul 3

The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social

In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes

journals.lww.com/greenjournal...

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Reposted by Michael Honigberg

Jon Pagtakhan @jonpheart.bsky.social · Jun 6

Missed the deadline? Plot twist: You didn't!
Deadlines extended! 🗓️
#AHA25 & #ReSS25 abstracts now due 6/9 at 10am ET.
Award applications due 6/9 at 7pm ET.
Submit here:
🔹 AHA: bit.ly/2025Extension
🔹 ReSS: bit.ly/ReSSExtension
@ahascience.bsky.social #CardioSky

Scientific Sessions

Join us for FOUR days of programming, November 7–10, 2025, for AHA's Scientific Sessions (#AHA25) at the Ernest N. Morial Convention Center in New Orleans, Louisiana. It's AHA's biggest cardiova...

bit.ly

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Reposted by Michael Honigberg

Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · Jun 5

The inaugural MGB & Inova YIA was a huge success 🎉Please join us in congratulating 👏👏
Basic & Translational category:
Winner: Maria Pabon (BWH)
Honorable Mention: Amelie Vromman (BWH)
Clinical Research category:
Winner: Meesha Vullikanti (Yale)
Honorable Mention: Izza Shahid (Houston Methodist)

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Michael Honigberg @mchonig.bsky.social · May 29

Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social

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Michael Honigberg @mchonig.bsky.social · May 10

Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social

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Reposted by Michael Honigberg

CardioOB @cardioob.bsky.social · Apr 28

Genetic Risk & 1st-Trimester CV Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women

#CardioObstetrics #CardioSky #JACC
www.jacc.org/doi/10.1016/...
@mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social

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Michael Honigberg @mchonig.bsky.social · Apr 8

Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC

First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)

overall and across levels of HDP genetic risk

www.jacc.org/doi/10.1016/...

#CardioObstetrics #CardioSky

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Reposted by Michael Honigberg

Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · Apr 2

We love our team ❤️ Check out @mchonig.bsky.social's latest review!

Michael Honigberg @mchonig.bsky.social · Apr 2

Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social

www.nature.com/articles/s41...

Full text link: rdcu.be/ef9VW

@mgbresearch.bsky.social @mgbwomenheart.bsky.social

Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target - Nature Reviews Cardiology

In this Review, Schuermans and Honigberg highlight the involvement of clonal haematopoiesis of indeterminate potential (CHIP) in cardiovascular diseases, such as atherosclerosis and heart failure, and...

www.nature.com

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Michael Honigberg @mchonig.bsky.social · Apr 2

… posted prematurely/in error without acknowledging the awesome work of lead author and overall rockstar @artschuermans.bsky.social !

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Michael Honigberg @mchonig.bsky.social · Apr 2

Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social

www.nature.com/articles/s41...

Full text link: rdcu.be/ef9VW

@mgbresearch.bsky.social @mgbwomenheart.bsky.social

Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target - Nature Reviews Cardiology

In this Review, Schuermans and Honigberg highlight the involvement of clonal haematopoiesis of indeterminate potential (CHIP) in cardiovascular diseases, such as atherosclerosis and heart failure, and...

www.nature.com

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Michael Honigberg @mchonig.bsky.social · Apr 2

@mgbwomenheart.bsky.social

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Michael Honigberg @mchonig.bsky.social · Apr 2

Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social

professional.heart.org/en/education...

Role of Cardiovascular Health in Maternal Health

Explore the role of cardiovascular health in maternal well-being. Learn warning signs, improve communication, and access life-saving tools.

professional.heart.org

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Reposted by Michael Honigberg

Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · Mar 27

Our team is gearing up for #ACC25! We'd love to see you! Come find us at one of our sessions! 🩺♥️
@mchonig.bsky.social @mdharringtonc.bsky.social @accintouch.bsky.social

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