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meisellab.bsky.social @meisellab.bsky.social · 7d

Thanks for highlighting our work!

Eric Topol @erictopol.bsky.social · 7d

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...

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Pitt Department of Immunology @pitt-immunology.bsky.social · 15d

Congrats, @catmphelps.bsky.social !

Pitt Program in Microbiology & Immunology @pitt-pmi.bsky.social · 15d

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

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Pitt Program in Microbiology & Immunology @pitt-pmi.bsky.social · 15d

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

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Open Box Science @openboxscience.bsky.social · Aug 28

🔬 OBS Seminar

Shaping CD8+ T Cell Response Through Microbiota Metabolites
🗣️ Joseph Stevens @cincyresearch.bsky.social @cincykidsallergyim.bsky.social
🗣️@catmphelps.bsky.social @meisellab.bsky.social

🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET

👇 us02web.zoom.us/meeting/regi...

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Nature Reviews Cancer @natrevcancer.nature.com · Aug 5

#ResearchHighlight

In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.

👇

No strain, no formate gains - Nature Reviews Cancer

In a study published in Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota and anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.

www.nature.com

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meisellab.bsky.social @meisellab.bsky.social · Jul 22

Congratulations to the team! Excited to see the study in print!!

Reinhard Hinterleitner @rh-lab.bsky.social · Jul 22

Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestin...

www.cell.com

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Reinhard Hinterleitner @rh-lab.bsky.social · Jul 22

Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestin...

www.cell.com

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meisellab.bsky.social @meisellab.bsky.social · Jul 17

congrats Alex!

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The American Association of Immunologists @aai.org · Jul 15

AAI Members in the News! For her grad thesis with Dr. Marlies Meisel at ‪@pittdeptofmed.bsky.social‬, ‪@catmphelps.bsky.social‬ showed how #exercise improves #cancer outcomes and enhances the response to #immunotherapy in mice by reshaping the gut #microbiome
🔗 www.medschool.pitt.edu/news/gut-mic...

Headshots of Dr. Marlies Meisel and Catherine Phelps side by side.

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meisellab.bsky.social @meisellab.bsky.social · Jul 11

Amazing! Congratulations Ruth

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meisellab.bsky.social @meisellab.bsky.social · Jul 11

Thanks @nature.com for highlighting our recent study #exercise #microbiota #cancer

Nature @nature.com · Jul 10

Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate

go.nature.com/4lIZx2m

Workouts can help gut microbes to quell cancer

Mice that exercised produced higher levels of an immune-cell-stimulating molecule than sedentary rodents did.

go.nature.com

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New Scientist @newscientist.com · Jul 9

Exercise seems to help prevent cancer and reduce the growth of tumours, but until now, we didn’t know why. The key seems to lie in the gut’s microbiome.

Exercise helps fight cancer – and we may finally know why

Exercise seems to help prevent cancer and reduce the growth of tumours, and that protective effect may be due to the way working out changes the gut microbiome

www.newscientist.com

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Waggoner Lab @labwaggoner.bsky.social · Jul 10

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social
www.cell.com/cell/fulltex...

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Adriana Forero @adforu.bsky.social · Jul 10

📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P

meisellab.bsky.social @meisellab.bsky.social · Jul 9

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

www.cell.com

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meisellab.bsky.social @meisellab.bsky.social · Jul 10

thanks Ruth!

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meisellab.bsky.social @meisellab.bsky.social · Jul 9

www.upmc.com/media/news/0...

Gut Microbes Key to Understanding How Exercise Boosts Cancer Immunity

www.upmc.com

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Cell - a Cell Press journal @cp-cell.bsky.social · Jul 9

Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

dlvr.it

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Catherine Phelps @catmphelps.bsky.social · Jul 9

I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today.

Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃‍♀️🦠

authors.elsevier.com/c/1lPCrL7PXu...

authors.elsevier.com

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Eric Topol @erictopol.bsky.social · Jul 9

How exercise works through the gut microbiome to enhance response to cancer immunotherapy
www.cell.com/cell/fulltex... @cellpress.bsky.social

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meisellab.bsky.social @meisellab.bsky.social · Jul 9

Very proud of first-author @[email protected] and other lab members!
Thanks to our collaborators @gottschalklab.bsky.social, zarourhm.bsky.social, especially @rh-lab.bsky.social many more (not on bsky)

zarourhm.bsky.social

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meisellab.bsky.social @meisellab.bsky.social · Jul 9

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

www.cell.com

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The New York Times @nytimes.com · Jun 2

A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.

Exercise Extends Life for People With Cancer, Study Shows

The trial, in people treated for colon cancer, showed clear evidence that an exercise program lowered the risk of disease recurrence and death.

trib.al

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Eric Topol @erictopol.bsky.social · Jun 1

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....

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meisellab.bsky.social @meisellab.bsky.social · May 5

not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM

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Barbara Marte @barbmarte.bsky.social · May 1

also a new N&V www.nature.com/articles/d41...

Microbial molecule of ageing gut nudges blood stem cells towards cancer

The risk of developing blood cancer increases with age. The finding that a molecule from gut bacteria plays a part points to new ways to intervene.

www.nature.com

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