merveyigit.bsky.social
Merve Yigit
@merveyigit.bsky.social
66 followers 140 following 6 posts
PhD student in Sendoel Lab | eIF2A | skin cancer | RNA biology | Translation
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merveyigit.bsky.social
Merve Yigit @merveyigit.bsky.social · Jun 29
PhDone 🥳🎓

The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
sendoellab.bsky.social
Sendoel Lab @sendoellab.bsky.social · Jun 27
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
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merveyigit.bsky.social
Merve Yigit @merveyigit.bsky.social · Jul 26
Check out the latest work from our lab! Amazing job @dadita.bsky.social 👏🏻👏🏻💯
dadita.bsky.social
David Taborsky @dadita.bsky.social · Jul 25
How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!
biorxiv-devbio.bsky.social
bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Jul 22
Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids https://www.biorxiv.org/content/10.1101/2025.07.22.666114v1
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merveyigit.bsky.social
Merve Yigit @merveyigit.bsky.social · Jun 29
PhDone 🥳🎓

The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
sendoellab.bsky.social
Sendoel Lab @sendoellab.bsky.social · Jun 27
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
1 6
merveyigit.bsky.social
Merve Yigit @merveyigit.bsky.social · Jun 29
Thank you! It was an incredible journey. Many thanks to all my committee members, great collaborations and amazing supervision!
Reposted by Merve Yigit
nccr-rna-disease.bsky.social
NCCR RNA & Disease @nccr-rna-disease.bsky.social · May 27
Preprint by the Sendoel Lab ( @sendoellab.bsky.social ) with first author Merve Yigit ( @merveyigit.bsky.social‬ "The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control"
@biorxivpreprint.bsky.social‬
buff.ly/hP9Iani
‪@anupamd.bsky.social‬
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merveyigit.bsky.social
Merve Yigit @merveyigit.bsky.social · May 26
#alternativetranslation #cancer #scc #ribosomequalitycontrol #ribosome #skin #usp10 #g3bp1 #rnf10 #ubiquitin #turboID #silac #massspectrometry #proteomics #riboseq #eIF2A #translation #mRNA
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merveyigit.bsky.social
Merve Yigit @merveyigit.bsky.social · May 26
I’m thrilled to share my very first first-author preprint and our lab’s latest work💫 We discovered a novel role for eIF2A in ribosome-associated quality control (RQC), challenging decades-old assumptions about its enigmatic function in translation initiation.

Check it out to learn more! ⭐️
#RNA
sendoellab.bsky.social
Sendoel Lab @sendoellab.bsky.social · May 26
Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x

www.biorxiv.org/content/10.1...
The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control
The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...
www.biorxiv.org
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merveyigit.bsky.social
Merve Yigit @merveyigit.bsky.social · Dec 12
Oh, the weather outside is frightful
But the paper submission is so delightful
And since we've no results yet
Let it pipette, let it pipette, let it pipette
claradure.bsky.social
Clara Duré @claradure.bsky.social · Dec 12
It‘s beginning to look a lot like Christmas🎄 when you suddenly need two additional pairs of helping hands 🐙 🧪
@merveyigit.bsky.social @fabiolavaldiviaf.bsky.social
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Reposted by Merve Yigit
sendoellab.bsky.social
Sendoel Lab @sendoellab.bsky.social · Nov 18
How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6

www.biorxiv.org/content/10.1...
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