Matthias Farlik
@mfarlik.bsky.social
3.9K followers
2K following
600 posts
PI of the INIMAC - Innate Immune Activation Lab - with a focus on innate immune cells and mechanisms leading to their activation. Immunology + NGS-Tech-Dev is where I come from. Functional screens rock! @meduniwien.ac.at. Opinions expressed are my own!
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Matthias Farlik
@mfarlik.bsky.social
· Nov 15
Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures
Background Patient-derived colorectal cancer (CRC) organoids (PDOs) solely consisting of malignant cells led to major advances in the understanding of cancer treatments. Yet, a major limitation is the...
bit.ly
Reposted by Matthias Farlik
Reposted by Matthias Farlik
Reposted by Matthias Farlik
Matthias Farlik
@mfarlik.bsky.social
· Aug 26
Matthias Farlik
@mfarlik.bsky.social
· Aug 24
Matthias Farlik
@mfarlik.bsky.social
· Aug 21
Reposted by Matthias Farlik
Stefan Lassnig
@stefanlassnig.bsky.social
· Aug 20
Pilnaceks letzte Nacht: nur sechs Minuten allein - zackzack.at
Ist Christian Pilnacek am 20. Oktober 2023 um 4.03 Uhr verstorben? Und: War Pilnacek in seiner letzten Nacht nur sechs Minuten allein? Erste Antworten finden sich im IT-Bericht, mit dem die WKStA Piln...
zackzack.at
Matthias Farlik
@mfarlik.bsky.social
· Aug 16
Matthias Farlik
@mfarlik.bsky.social
· Aug 15
Matthias Farlik
@mfarlik.bsky.social
· Aug 15
Reposted by Matthias Farlik
Reposted by Matthias Farlik
Reposted by Matthias Farlik
Immunity
@cp-immunity.bsky.social
· Aug 12
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflammation-induced PF. Mechanistically, nociceptor depletion results in aberrant production of the neuropeptide VIP by alveolar macrophages, which increases TGF-β1 levels and causes Siglec-F+ neutrophils to release NETs that contribute to PF pathology.
dlvr.it
Reposted by Matthias Farlik
Matthias Farlik
@mfarlik.bsky.social
· Aug 12
Matthias Farlik
@mfarlik.bsky.social
· Aug 11
Reposted by Matthias Farlik