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Reposted by Mathew Garnett

Cancer Research UK Manchester Institute @cruk-mi.bsky.social · 14d

Exciting news - we are recruiting new Group Leaders! 🥼

We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes

Full details on our website: www.cruk.manchester.ac.uk/career/new-g...

Group Leader Recruitment at the Cancer Research UK Manchester Institute

YouTube video by CRUK Manchester Institute

youtu.be

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Mathew Garnett @mgarnett.bsky.social · 18d

DepMap Miner features:
· Tailor model data selections
· Explore relationships between 'omics' data
· customisable plots
· Visualise gene dependencies across 900+ cell lines
· Export data easily to continue exploring
Discover more: dataminer.depmap.sanger.ac.uk

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Mathew Garnett @mgarnett.bsky.social · 18d

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.

Start mining data now: dataminer.depmap.sanger.ac.uk

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Reposted by Mathew Garnett

Anna Obenauf @obenaufa.bsky.social · Sep 4

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Full Professorship in Molecular Mechanisms of Disease

The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...

www.maxperutzlabs.ac.at

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Mathew Garnett @mgarnett.bsky.social · Jul 20

Excited to be on my was to the GRC synthetic lethal approaches in oncology conference #GRCSyntheticLethal. Some stellar science kicking off tonight. In the meantime enjoying the beautiful scenery on the drive up the Maine coast.

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Reposted by Mathew Garnett

Wellcome Sanger Institute @sangerinstitute.bsky.social · Jul 4

A new drug target that has the potential to treat aggressive eye cancer has been discovered 👁️

This research may provide a hopeful outlook for eye cancer patients with very limited treatment options and has implications for a range of other cancers ⤵️

www.sanger.ac.uk/news_item/ne...

Group Leader at the Wellcome Sanger Institute, David Adams stands outdoors, discussing the significant genetic discovery related to uveal melanoma and cancer therapy. His quote reads: “Our study reveals a previously unrecognised genetic relationship in uveal melanoma, driven by a particular relationship between the CDS1 and CDS2 genes. This discovery not only deepens our understanding of tumour biology but also opens new routes for precise therapy development. What makes this finding especially exciting is its relevance beyond uveal melanoma as our research suggests a therapeutic potential for a broad range of cancers.”

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Reposted by Mathew Garnett

Wellcome Sanger Institute @sangerinstitute.bsky.social · Jun 25

Join the Frontier of Cellular Genomics at Wellcome Sanger Institute. We are looking for Group Leaders to drive innovative science with core funding, cutting-edge technology, and global impact.

Apply now: lnkd.in/eqneJFVt

📅 Closing date: 17 August

#GroupLeader #FacultyPosition #CambridgeScience

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Reposted by Mathew Garnett

Elizabeth McKenna @elizsmckenna.bsky.social · Jun 24

Now online in Cancer Discovery: AAnet Resolves a Continuum of Spatially-Localized Cell States to Unveil Intratumoral Heterogeneity - by Aarthi Venkat, Scott Youlten, Beatriz San Juan, Smita Krishnaswamy, Christine Chaffer, and colleagues doi.org/10.1158/2159...

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Reposted by Mathew Garnett

Helmholtz Munich @helmholtzmunich.bsky.social · Jun 13

Cancer Plasticity Atlas To Improve Cancer Therapies

#HelmholtzMunich joins @sangerinstitute.bsky.social & @parse.bsky.social to build the Cancer Plasticity Atlas, using #AI & single-cell data to model therapy response.

👉 t1p.de/13ifi

@fabiantheis.bsky.social
@mgarnett.bsky.social

#CancerResearch

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Reposted by Mathew Garnett

Wellcome Sanger Institute @sangerinstitute.bsky.social · Jun 12

Announcing a new collaboration with @parse.bsky.social @www.helmholtz-munich.de to develop a #Cancer Plasticity Atlas.

The reference map will help predict the effect of cancer drugs - where resistance might develop and where to target future treatment efforts.

www.sanger.ac.uk/news_item/pi...

Pioneering cancer plasticity atlas will help predict response to cancer therapies

Utilising novel organoid perturbation and Artificial Intelligence (AI) platforms, the aim is to create a comprehensive dataset to fuel foundational drug discovery models and cancer research.

www.sanger.ac.uk

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Mathew Garnett @mgarnett.bsky.social · Jun 12

This is going to be a great event showcasing cutting edge science.

Francesco Iorio @francescoiorio.bsky.social · Jun 11

🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR

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Mathew Garnett @mgarnett.bsky.social · Jun 6

Don't miss your chance to register for the GRC conference on Synthetic Lethality Approaches in Oncology this July in beautiful Maine (near Boston). We have stellar speakers, with a mix from academia and industry in this translational space. There are speaker slots from abstracts.

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Reposted by Mathew Garnett

Victor Javier @vjsanchez.bsky.social · May 31

MLOmics: Cancer Multi-Omics Database for Machine Learning 🧪 🧬🖥️ www.nature.com/articles/s41...

MLOmics: Cancer Multi-Omics Database for Machine Learning - Scientific Data

Scientific Data - MLOmics: Cancer Multi-Omics Database for Machine Learning

www.nature.com

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Mathew Garnett @mgarnett.bsky.social · May 27

For students & trainees, there are speaking slots for selected abstracts at the upcoming GRC conference on Synthetic Lethality in Oncology (www.grc.org/synthetic-le...). The informal small meeting format is perfect for networking and to find your next career opportunity. Bursaries available.

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Mathew Garnett @mgarnett.bsky.social · May 22

Check out the first session for the upcoming GRC conference on synthetic lethality in oncology www.grc.org/synthetic-le.... Top flight speakers - Simon Powell (MSK), Chris Lord (ICR), and plenary talk from William Sellers (Broad Inst.). What a start! It's not too late to register.

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Mathew Garnett @mgarnett.bsky.social · May 22

Check this out if you're interested in #crispr #baseeditor. Congratulations Cansu for creating this wonderful tool.

Cansu Dinçer @cansudincer.bsky.social · May 22

🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor

bioRxivpreprint @biorxivpreprint.bsky.social · May 20

BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments https://www.biorxiv.org/content/10.1101/2025.05.19.654892v1

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Reposted by Mathew Garnett

European Research Council (ERC) @erc.europa.eu · May 16

Today, the ERC formally adopted a decision to increase its support for researchers moving to Europe.

On top of its normal grants, the ERC offers 'start-up' funding to help PIs establish laboratories / research teams in Europe.

This extra funding is now x2 (up to €2 million!)

europa.eu/!6Vdgmp

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Mathew Garnett @mgarnett.bsky.social · May 12

Learn about the future of synthetic lethality in oncology at the upcoming Gordon Research Conference. This is the inaugural meeting and WOW what a lineup! We have a truly phenomenal program, with top speakers from academia and industry. Check it out at the link below.
www.grc.org/synthetic-le....

2025 Synthetic Lethality Approaches in Oncology Conference GRC

The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.

www.grc.org

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Reposted by Mathew Garnett

European Commission @ec.europa.eu · May 8

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

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Reposted by Mathew Garnett

Tom Ellis @proftomellis.bsky.social · May 2

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...

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Reposted by Mathew Garnett

Gabriele Picco @gabrielepicco.bsky.social · Apr 28

Great talk by Yanhua Rao at #AACR2025 on GSK’s new clinical WRN inhibitor. Proud to see our unpublished data spotlighted for revealing new MoA insights. Exciting times ahead! @mgarnett.bsky.social

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Mathew Garnett @mgarnett.bsky.social · Apr 27

Six years after the discovery of WRN synthetic lethality in MSI cancers, WRN inhibitors hit center stage again today at #aacr25 with report of the first in human phase 1 trial data for RO7589831. Can’t wait to see it!

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Reposted by Mathew Garnett

Inigo Martincorena @imartincorena.bsky.social · Apr 26

I am speaking at #AACR25 this afternoon on our latest work on somatic mutations in normal tissues. If you are attending AACR, feel free to drop by and say hello.
brnw.ch/21wRUZZ

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Reposted by Mathew Garnett

Gabriele Picco @gabrielepicco.bsky.social · Apr 25

Just landed in Chicago for #AACR25 — Millennium Park in bloom! Excited for team talks on WRN inhibitors in MSI cancers, with first-in-human data discussed by @mgarnett.bsky.social at the Clinical Trials Plenary. I’ll present new data on WRNi-driven evolution — Poster #420! #MSI #SyntheticLethality

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Reposted by Mathew Garnett

Matt Coelho @mattcoelho.bsky.social · Apr 22

Excited to announce our preprint today @biorxivpreprint.bsky.social
Using functional genomics, we map the genetic determinants cancer cell sensitivity to tumour-reactive T cells:
www.biorxiv.org/content/10.1...

CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance

Cancer immunotherapy is only effective in a subset of patients, highlighting the need for effective biomarkers and combination therapies. Here we systematically identify genetic determinants of cancer...

www.biorxiv.org

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