Lightnews — Scholar-powered news

mikakivimaki.bsky.social @mikakivimaki.bsky.social · Jul 16

New multicohort resource for researchers exploring proteomics in neurodegenerative diseases — including data from the Whitehall II study. 🧠🔬

www.nature.com/articles/s41...

The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging - Nature Medicine

The largest harmonized proteomic dataset of plasma, serum and cerebrospinal fluid samples across major neurodegenerative diseases reveals both disease-specific and transdiagnostic proteomic signatures...

www.nature.com

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Whitehall II Study @whitehall2study.bsky.social · May 29

It was a pleasure to celebrate Whitehall II's 40th anniversary this month at UCL with Professor Sir Michael Marmot who set up the study in 1985. Watch the recording of the event here: www.youtube.com/watch?v=__gL...

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mikakivimaki.bsky.social @mikakivimaki.bsky.social · May 28

Workplaces are an important but underused channel for health promotion – a new review examines the most effective strategies.

www.thelancet.com/journals/lan...

Effectiveness of workplace interventions for health promotion

Workplaces are an important setting for health promotion, offering established infrastructure, daily access to large populations, and opportunities to engage groups that are often under-represented in...

www.thelancet.com

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Eric Topol @erictopol.bsky.social · May 27

2 new studies on weight loss
1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam...
2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...

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mikakivimaki.bsky.social @mikakivimaki.bsky.social · May 27

Long-term follow-up shows that losing weight in midlife—without surgery or medication—can lower the risk of chronic diseases later in life

jamanetwork.com/journals/jam...

Weight Loss in Midlife, Chronic Disease Incidence, and All-Cause Mortality

This cohort study investigates the association of sustained weight loss in midlife with long-term health benefits.

jamanetwork.com

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Eric Topol @erictopol.bsky.social · May 26

My conversation with Sir John Bell, one of the most influential physician-scientists in the world.
(it's free, with transcript)
erictopol.substack.com/p/sir-john-b...

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mikakivimaki.bsky.social @mikakivimaki.bsky.social · May 25

A state-of-the-art review with 1700+ references unpacks how systemic factors shape brain and vascular ageing—drawing on parabiosis, blood exchange and plasma transfer studies.

link.springer.com/content/pdf/...

link.springer.com

mikakivimaki.bsky.social @mikakivimaki.bsky.social · May 25

A 10-year gap in frailty-free life expectancy between the highest and lowest socioeconomic groups.

link.springer.com/article/10.1...

Frailty-free life expectancy and its association with socio-economic characteristics: an analysis of the English Longitudinal Study of Ageing cohort study - BMC Medicine

Background Frailty is more prevalent in socio-economically disadvantaged groups; however, little is known about how this translates to differences in the number of years people live with and without f...

link.springer.com

Reposted

Eric Topol @erictopol.bsky.social · May 11

Multiple recent studies, including 3 impressive natural experiments, consistently show a link between Shingles vaccines and reduced dementia. This week a nationwide S Korea study added a reduction of cardiovascular events
My summary Table. More here on dementia erictopol.substack.com/p/the-shingl...

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Eric Topol @erictopol.bsky.social · May 8

Things with evidence that promote healthy aging, and I've adopted
gift link
www.wsj.com/health/welln...

A Doctor’s Science-Backed Formula for Aging Better

Dr. Eric Topol’s research revealed it’s not so much genes that lead to long life but instead simple and practical steps to stay healthy. He’s taking his own advice.

www.wsj.com

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Nature Portfolio @natureportfolio.nature.com · Apr 22

Reducing high blood pressure substantially lowers the risk of dementia and cognitive impairment without dementia, according to the results of a clinical trial published in Nature Medicine. go.nature.com/44z6kGy #medsky 🧪

This is figure 2, which shows SBP and DBP in the intervention and usual care groups over the 48 months of follow-up.

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Nature Portfolio @natureportfolio.nature.com · Apr 21

A study in Nature Medicine shows that a meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors had superior performance in predicting the 10-year risk of coronary artery disease. go.nature.com/4igXqAJ 🔒

This is figure 1, which gives an overview of cohort construction, model development and performance assessment for 10-year incident CAD risk meta-prediction in the UKBB.

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JAMA @jama.com · Apr 17

The future burden of dementia in the US may be substantially lower than current projections.

Watch and learn more, then read the full JAMA Viewpoint on the changing story of the dementia epidemic. jamanetwork.com/journals/jam...

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Eric Topol @erictopol.bsky.social · Apr 4

In case you follow me @X, my account was HACKED and someone is impersonating me selling bitcoin (and who knows what else to come).
Beyond that, all attempts to contact X to rectify the matter go nowhere.
If you have an account there, and get the chance, please post so people will know. Thanks!

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Eric Topol @erictopol.bsky.social · Mar 18

Do viruses play a role in the cause of Alzheimer's disease?
In the wake of observational studies showing some protection from the vaccines vs. shingles
www.economist.com/science-and-...
Unclear, but an ongoing clinical trial of valacyclovir, an anti-viral, may help to resolve

Do viruses trigger Alzheimer’s?

A growing group of scientists think so, and are asking whether antivirals could treat the disease

www.economist.com

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Eric Topol @erictopol.bsky.social · Mar 14

We've known social disadvantage was linked to adverse health outcomes. A @NatureMedicine study used high- throughput proteomics to show there is accelerated aging, increased risk of 66 age-related diseases, and unfavorable changes in the immune system, ⬆️ inflammation
www.nature.com/articles/s41...

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mikakivimaki.bsky.social @mikakivimaki.bsky.social · Mar 14

This multicohort study links social disadvantage to accelerated ageing, highlighting NF-κB activation as a key underlying mechanism.

#Aging #SocialDeterminants #NFkB

rdcu.be/edyqo

Social disadvantage accelerates aging

Nature Medicine - Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.

rdcu.be

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mikakivimaki.bsky.social @mikakivimaki.bsky.social · Mar 12

New study on excess deaths during the COVID-19 pandemic across 18 European countries

 –Countries with lower GDP saw a greater loss of years of life 

–Higher vaccination coverage was linked to fewer years of life lost—independent of GDP

#PublicHealth #Vaccination

journals.plos.org/plosmedicine...

Direct and indirect impacts of the COVID-19 pandemic on life expectancy and person-years of life lost with and without disability: A systematic analysis for 18 European countries, 2020–2022

Sara Ahmadi-Abhari and colleagues explore the impact that the COVID-19 pandemic might have had on life expectancy and years of life lost, with and without disability, in 18 European countries. They ho...

journals.plos.org

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Eric Topol @erictopol.bsky.social · Mar 11

The person-years of life lost from the pandemic (here for Europe) with premature mortality reflects an underestimate of the toll of Covid @plos.org
journals.plos.org/plosmedicine...

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Philipp Frank @philippfrank.bsky.social · Feb 26

🔬Our latest research published in the Lancet Digital Health shows that different organs age at different rates, and that accelerated biological ageing is linked to a higher risk of age-related diseases—including multimorbidity across multiple organs.
www.thelancet.com/journals/lan...

Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study

Advanced proteomic organ ageing is associated with the long-term risk of age-related diseases. In most cases, faster ageing of a specific organ increases susceptibility to morbidity affecting multiple...

www.thelancet.com

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Eric Topol @erictopol.bsky.social · Feb 26

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...

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Eric Topol @erictopol.bsky.social · Feb 19

Our lifestyle and environmental exposures are the predominant influencers of healthy aging and premature mortality, compared with polygenic risk, in the first comprehensive assessment
www.nature.com/articles/s41...
open-access

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine

Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...

www.nature.com

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George Davey Smith @mendelrandom.bsky.social · Feb 22

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Aylwyn Scally @aylwyn-scally.bsky.social · Feb 22

Quantitative genetics is poorly understood by many biologists, and that's surely a failure in how it is taught. But teaching biology as 'fundamentally complex' seems like one of the least promising educational ideas since those 1970s schools that made lessons optional.
www.cell.com/cell-systems...

Should biology put complexity first?

The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing damage to its complex nature? The answer might be foun...

www.cell.com

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Eric Topol @erictopol.bsky.social · Feb 21

Worth reposting!

Eric Topol @erictopol.bsky.social · Jan 24

Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...

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mikakivimaki.bsky.social @mikakivimaki.bsky.social · Feb 4

Engaging in leisure-time physical activity adds 1–2 extra disease-free years, with greater benefits among smokers, those with social disadvantage, and individuals with depression.
💡 Boosting physical activity may reduce health disparities.
Read more: www.thelancet.com/journals/lan...

Health benefits of leisure-time physical activity by socioeconomic status, lifestyle risk, and mental health: a multicohort study

In addition to confirming the association between leisure-time physical activity and increased disease-free years across population subgroups, our findings show that these health benefits are often mo...

www.thelancet.com

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