Clustering Patients with Pulmonary Hypertension Using the Plasma Proteome

Plasma proteomics reveals four molecular clusters in pulmonary hypertension with distinct survival and therapeutic targets
@atscommunity.bsky.social #medsky

🔓 Open Access

🔗 tinyurl.com/bpa36xt7

It was a pleasure to celebrate Whitehall II's 40th anniversary this month at UCL with Professor Sir Michael Marmot who set up the study in 1985. Watch the recording of the event here: www.youtube.com/watch?v=__gL...

2 new studies on weight loss
1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam...
2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...

Long-term follow-up shows that losing weight in midlife—without surgery or medication—can lower the risk of chronic diseases later in life

jamanetwork.com/journals/jam...

People with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins, according to a paper in Nature Medicine. https://go.nature.com/4ifgD6T #Medsky 🧪

People with favourable socioeconomic conditions, e.g. high incomes or education levels, face a reduced risk of age-related diseases and show fewer signs of biological ageing than same-aged peers, finds a study led by Prof Mika Kivimaki @uclbrainscience.bsky.social with @ucllifesciences.bsky.social

This multicohort study links social disadvantage to accelerated ageing, highlighting NF-κB activation as a key underlying mechanism.

#Aging #SocialDeterminants #NFkB

rdcu.be/edyqo

✅ The main enriched pathway involved the upregulation of the pro-inflammatory regulator NF-κB2. Chronic stress—whether biological or social—can trigger activation of this pathway. Persistent activation accelerates tissue damage and increases susceptibility to age-related conditions.

✅ Social disadvantage is associated with proteomic signatures of accelerated immune aging
✅ 14 age-related #proteins mediate up to 39% of the link between social disadvantage and age-related diseases
✅ Individuals facing social disadvantage had an increased risk for 66 age-related diseases

#Ageing is not just about time - it is also shaped by social conditions. In our latest study published in @naturemedicine.bsky.social , we show that social disadvantage is linked to biological ageing @mikakivimaki.bsky.social @uclbrainscience.bsky.social @whitehall2study.bsky.social

Our latest publication in the Lancet Digital Health shows that organs age at different rates. Proteomic data from 6235 Whitehall II Study participants revealed that accelerated ageing of specific organs are predictive for over 30 age-related diseases. Link to paper: www.thelancet.com/journals/lan...

Our organs age at different rates, and a blood test determining how much they’ve aged could predict the risk of conditions like lung cancer and heart disease decades later, finds a new study led by Prof Mika Kivimaki @uclbrainscience.bsky.social @whitehall2study.bsky.social

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...

Our research has also been featured in the @financialtimes.com www.ft.com/content/9510...

📌 In most cases, ageing of one organ increased susceptibility to diseases in multiple organs.

📌 Plasma-based organ age signatures could provide a quick, non-invasive way to improve disease prediction and prevention.
@uclpsychiatry.bsky.social @helsinki.fi www.ft.com/content/9510...

📌 Faster organ ageing was associated with an increased risk of 30 age-related diseases.

📌 The development of some diseases—such as liver failure, chronic heart failure, and lung cancer—was exclusively associated with accelerated ageing of their respective organ.

Using proteomic data from 6,235 participants of the Whitehall II study , we determined how much an organ's biological age deviates from what’s typically expected for someone of the same age. We then tracked participants for 20 years to examine their risk of developing 45 age-related diseases.

🔬Our latest research published in the Lancet Digital Health shows that different organs age at different rates, and that accelerated biological ageing is linked to a higher risk of age-related diseases—including multimorbidity across multiple organs.
www.thelancet.com/journals/lan...