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Reposted by Manpreet Mundi

ryanhurt9296.bsky.social @ryanhurt9296.bsky.social · 13d

Dr. Mundi @mmundi.bsky.social presenting about GLP-1 at the annual KYSPEN meeting.

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Reposted by Manpreet Mundi

Dr. Karl Nadolsky @drkarlnadolsky.bsky.social · Jun 22

Orforglipron, small molecule GLP-1ra in type 2 #diabetes.
➡️mean HbA1c at baseline was 8.0%. At week 40, it dropped −1.24% with 3-mg, −1.47 % with 12-mg, −1.48 % with 36-mg dose, and −0.41 % with placebo.

www.nejm.org/doi/full/10....

#ADA2025

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | NEJM

Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and ...

www.nejm.org

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Manpreet Mundi @mmundi.bsky.social · Jun 22

A consequence of climate change being worsening sleep apnea is something I never even considered. 🍎🧪

Nature Portfolio @natureportfolio.nature.com · Jun 22

A study in Nature Communications quantifies how rising temperatures linked to climate change would increase the severity of obstructive sleep apnea (OSA) and reports projected losses of healthy life years and workplace productivity due to OSA. go.nature.com/3HMqsMg #medsky 🧪

This is figure 3, which shows projected wellbeing burden of warming-related increase in moderate-to-severe obstructive sleep apnea (OSA) prevalence.

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Manpreet Mundi @mmundi.bsky.social · Jun 22

Our toolbox for management of #obesity continues to grow with phase 3 data being released today for the combination of cagrilinitide and semaglutide. Average weight loss for the combined drugs was over 20% and side-effect profile was similar to semaglutide. #Medsky 🧪🍎 www.nejm.org/doi/full/10....

Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity | NEJM

Semaglutide at a dose of 2.4 mg has established weight-loss and cardiovascular benefits, and cagrilintide at a dose of 2.4 mg has shown promising results in early-phase trials; the efficacy of the ...

www.nejm.org

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Eric Topol @erictopol.bsky.social · Jun 21

Outstanding review of neuroinflammation and dysfunction in #LongCovid onlinelibrary.wiley.com/doi/full/10....
@virusesimmunity.bsky.social @jannamoen.bsky.social

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NPR @npr.org · May 19

If you're trying to build muscle, getting enough protein is a must. But does it matter if that protein comes from meat or plants? A new study overturns assumptions.

Protein for strength training? Vegan diet matches meat for muscle gains

If you're trying to build muscle, getting enough protein is a must. But does it matter if that protein comes from meat or plants? A new study overturns assumptions.

www.npr.org

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Manpreet Mundi @mmundi.bsky.social · May 4

Analysis of Epic Cosmos data shows use of semaglutide and tirzepatide continues to increase for management of #Obesity now at 2.3% of eligible adults. Discrepancies in prescribing remain based on race and where you live. #Medsky

jamanetwork.com/journals/jam...

Semaglutide and Tirzepatide Prescribing for Obesity

This study uses data from the US nationwide electronic health record–based Epic Cosmos Dataset to examine prescriptions for semaglutide and tirzepatide, focusing on differences across race, ethnicity,...

jamanetwork.com

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Manpreet Mundi @mmundi.bsky.social · Apr 16

This is such a tremendous loss for nutrition and obesity research. Truly hope you are able to continue your work elsewhere especially in Ultra-processed foods.

Kevin Hall @kevinh-phd.bsky.social · Apr 16

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.

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Reposted by Manpreet Mundi

Thanh Nha Thai, MD @thaithanhnha.bsky.social · Apr 10

Sedentary Behavior and Light-Intensity Physical Activity During Pregnancy and Cardiovascular Health: A Science Advisory From the American Heart Association.

www.ahajournals.org/doi/epub/10....

@ahajournals.bsky.social @ahascience.bsky.social
#CardioSky #MedSky #Circulation

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ZhenggangZhu @zhenggang.bsky.social · Mar 30

(1/n) Why is it so hard to stop eating when something tastes amazing? Our new @ science.org paper reveals that dopamine helps sustain our drive for tasty treats—and may explain how anti-obesity Ozempic tames those urges. doi.org/10.1126/science.adt0773

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Manpreet Mundi @mmundi.bsky.social · Mar 30

Do artificial sweeteners increase our appetite? This study using fMRI seems to show that artificial sweeteners activate key regions of the hypothalamus that regulate appetite. #Medsky #Obesity 🧪🍎
www.nature.com/articles/s42...

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights - Nature Metabolism

In a randomized, crossover clinical trial in healthy young adults with varying weights, sucralose increased hypothalamic blood flow and its functional connections with brain regions involved in motiva...

www.nature.com

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Reposted by Manpreet Mundi

Elizabeth Gibney @lizziegibney.bsky.social · Mar 27

This is such an amazing study. Researchers tracked people over 300,000 births looking at how biomarkers change & recover postpartum. ~60% stabilise close to pre-conception levels after 3 months, but some (eg for bone & liver health) take a year. Others never recover! 🧪 www.nature.com/articles/d41...

Gigantic birth study paints most detailed picture of pregnancy’s toll on body

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

www.nature.com

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Manpreet Mundi @mmundi.bsky.social · Mar 15

Are tirzepatide and semaglutide cost effective? Although they would reduce 20,854 & 19,211 cases of DM2 and 10,655 and 8263 cases of CVD per 100K respectively, their prices would require a 30.5% and 81.9% reduction from current price to be “cost-effective" #Medsky 🧪

jamanetwork.com/journals/jam...

Lifetime Health Effects and Cost-Effectiveness of Tirzepatide and Semaglutide in US Adults

This study compares the cost-effectiveness of 4 antiobesity medications (naltrexone-bupropion, phentermine-topiramate, semaglutide, or tirzepatide) with lifestyle modification vs lifestyle modificatio...

jamanetwork.com

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Stephen O'Rahilly @stephenorahilly.bsky.social · Feb 21

adiposetissue.org: A knowledge portal integrating clinical and experim... www.sciencedirect.com/science/arti... Thanks to the authors for providing a great online tool for the community

AT Knowledge Portal

adiposetissue.org

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Jennifer Gulas MD, FACP @doctorajgu.medsky.social · Feb 21

edhub.ama-assn.org/jn-learning/...

#obesity #oncsky #medsky #cancer

The Influence of Obesity on Cancer

Jennifer A. Ligibel, MD, from the Dana-Farber Cancer Institute and Harvard Medical School, Boston, explains how obesity influences the risk of developing cancer and how it influences the prognosis of existing cancer.

edhub.ama-assn.org

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Manpreet Mundi @mmundi.bsky.social · Feb 20

We do see similar rapid weight loss with bariatric surgery. So medication selection, ie the correct medication based on BMI and medical co-morbidities will be key. 🧪 #obesity #Medsky

Daniel Drucker @danieljdrucker.bsky.social · Feb 20

Next generation GLP-1 medicines for #weightloss Too much weight loss, too fast? @elaineywchen.bsky.social foreshadows experiences in the ongoing Retatrutide trials, and discusses broader implications for the field @statnews.com #obesity @matthewherper.bsky.social www.statnews.com/2025/02/20/t...

How much weight loss is too much? Pharma is pushing the limit with new obesity drugs

How much weight loss is too much? Pharma is pushing the limit with new obesity drugs.

www.statnews.com

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Manpreet Mundi @mmundi.bsky.social · Feb 19

Great review on cardiovascular fitness. Imagine if VO2 max was a vital sign measured annually. #Nutsky 🧪🍎

NEJM.org @nejm.org · Feb 18

Cardiorespiratory fitness is an indicator of future cardiac, metabolic, and health events and is a strong predictor of all-cause mortality. Brazile et al. review the basics of the cardiorespiratory response to exercise. Full article in NEJM Evidence: eviden.cc/3Pe9Ay8 

#MedSky #CardioSky #PulmSky

An illustrated diagram of aerobic and anaerobic respiration during physical activity.

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Manpreet Mundi @mmundi.bsky.social · Feb 17

Looking forward to ASPEN 2025. See you in Columbus.

Tom P. @runner-guy.bsky.social · Feb 16

Anyone else attending the ASPEN conference next month? It will be interesting to hear how NIH cuts and other cuts have affected nutrition research. #nutsky

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Manpreet Mundi @mmundi.bsky.social · Feb 12

Our review on Short chain fatty acids was just published. SCFA were once thought to just influence the gut mucosa locally, but now appear to have systemic effects: immune-modulation, anti-inflammatory, appetite suppression, mitochondrial function, etc.

#MedSky 🍎🧪
journals.lww.com/co-clinicaln...

Short-chain fatty acids in clinical practice: where are we? : Current Opinion in Clinical Nutrition & Metabolic Care

lued dietary substrate. Recent findings SCFAs act systemically through stimulation of G protein receptors (GPRs) and inhibition of histone deacetylases (HDACs). SCFAs cause appetite suppression, re...

journals.lww.com

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Manpreet Mundi @mmundi.bsky.social · Feb 5

Are GLP-1 receptor agonists associated with higher risk of thyroid cancer. It looks like there is only an increase in the first year most likely due to increased vigilance. Overall no increase compared to other diabetes medications. #Medsky #Obesity 🧪

jamanetwork.com/journals/jam...

GLP-1RA Use and Thyroid Cancer Risk

This secondary analysis of a target trial emulation of a comparative effectiveness study uses claims data to estimate the risk of incident thyroid cancer in adults with type 2 diabetes starting treatm...

jamanetwork.com

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Manpreet Mundi @mmundi.bsky.social · Feb 4

Hope to see ongoing research about the impact of microplastics.

Nature Portfolio @natureportfolio.nature.com · Feb 4

Tiny plastic particles may accumulate at higher levels in the human brain than in the kidney and liver, with greater concentrations detected in postmortem samples from 2024 than in those from 2016, suggests a paper in Nature Medicine. https://go.nature.com/414lf9S #Medsky 🧪

This is figure 2, which is a visualization of putative plastics in the brain.

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Manpreet Mundi @mmundi.bsky.social · Feb 4

Thanks for raising this issue. Really important to set social media curfew before bedtime especially in current political climate. #Medsky 🧪

Lizzie Benge, MD @lizziebenge.bsky.social · Feb 4

1/ Ever scrolled through social media late at night, only to feel more anxious & unable to sleep? 😵‍💫 You're not alone. Let's talk about how seeing stressful or disturbing content affects sleep and what you can do about it. 🧵👇 #SleepHealth

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Reposted by Manpreet Mundi

Eric Topol @erictopol.bsky.social · Jan 31

Sugar-sweetened beverages are associated with an increased risk of Type 2 diabetes. Now we may know why.
Changes in the gut microbiome and its metabolites
www.cell.com/cell-metabol...

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