MOCEL - Molecular & Cellular Biology Dept - University of Geneva
@mocel.bsky.social
From molecules to diseases
https://mocel.unige.ch/
https://mocel.unige.ch/
New article from Emmanuel Levy'Lab : they discovered that missense mutations in homomeric proteins can trigger supramolecular assembly but, remarkably, these folded protein assemblies are not toxic. A testament to cellular robustness!
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
September 18, 2025 at 12:15 PM
New article from Emmanuel Levy'Lab : they discovered that missense mutations in homomeric proteins can trigger supramolecular assembly but, remarkably, these folded protein assemblies are not toxic. A testament to cellular robustness!
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
September 16, 2025 at 4:22 PM
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
👏 Congratulations @elevylab.bsky.social for your latest publication in @molsystbiol.org: Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system @mocel.bsky.social #UNIGE
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
September 17, 2025 at 7:28 AM
👏 Congratulations @elevylab.bsky.social for your latest publication in @molsystbiol.org: Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system @mocel.bsky.social #UNIGE
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
🧬 New tool for U-ExM!
HAK-Actin is now available from Spirochrome → a reliable probe to label actin filaments in expansion microscopy.
Check it out at Spirochrome!
#UExM #Actin #Cytoskeleton #SuperResolution
HAK-Actin is now available from Spirochrome → a reliable probe to label actin filaments in expansion microscopy.
Check it out at Spirochrome!
#UExM #Actin #Cytoskeleton #SuperResolution
Discover HAK-actin™: A New Tool To Visualize The Actin Cytoskeleton by Expansion Microscopy
• Stronger signal via post-expansion labeling
• Broad cell lines & species compatibility
• Endogenous actin labeling
• Can be multiplexed with other targets
spirochrome.com/product/hak-...
• Stronger signal via post-expansion labeling
• Broad cell lines & species compatibility
• Endogenous actin labeling
• Can be multiplexed with other targets
spirochrome.com/product/hak-...
September 10, 2025 at 9:59 AM
🧬 New tool for U-ExM!
HAK-Actin is now available from Spirochrome → a reliable probe to label actin filaments in expansion microscopy.
Check it out at Spirochrome!
#UExM #Actin #Cytoskeleton #SuperResolution
HAK-Actin is now available from Spirochrome → a reliable probe to label actin filaments in expansion microscopy.
Check it out at Spirochrome!
#UExM #Actin #Cytoskeleton #SuperResolution
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
🏅Congratulations to Emeritus Prof. Ueli #Schibler for receiving the #Kappers Medal from the #EBRS: the Society’s highest honor, awarded for outstanding contributions to biological rhythms research @sciencesunige.bsky.social @mocel.bsky.social #UNIGE
ebrs-online.org/index.php/abou
ebrs-online.org/index.php/abou
September 1, 2025 at 11:20 AM
🏅Congratulations to Emeritus Prof. Ueli #Schibler for receiving the #Kappers Medal from the #EBRS: the Society’s highest honor, awarded for outstanding contributions to biological rhythms research @sciencesunige.bsky.social @mocel.bsky.social #UNIGE
ebrs-online.org/index.php/abou
ebrs-online.org/index.php/abou
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
Congratulations @elevylab.bsky.social and collaborators for your latest publication in Cell 👏 and welcome to BlueSky 🦋@mocel.bsky.social @sciencesunige.bsky.social
Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science!
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import
Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in
human cells are imported during translation on cytosolic ribosomes. Cotranslational
import requires an N-terminal pres...
www.cell.com
August 22, 2025 at 6:51 AM
Congratulations @elevylab.bsky.social and collaborators for your latest publication in Cell 👏 and welcome to BlueSky 🦋@mocel.bsky.social @sciencesunige.bsky.social
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability
Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...
www.biorxiv.org
July 30, 2025 at 12:20 PM
🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
Congratulations Emeritus Prof. #Martinou from @mocel.bsky.social and collaborators for your latest publication in #Nature #Metabolism 👏 rdcu.be/eASgF
👉 Check #UNIGE press release:
www.unige.ch/medias/en/20...
👉 Check #UNIGE press release:
www.unige.ch/medias/en/20...
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
Nature Metabolism - Zangari et al. show that d-cysteine targets NFS1, thus affecting Fe–S cluster biogenesis and impairing tumour growth.
rdcu.be
August 15, 2025 at 8:37 AM
Congratulations Emeritus Prof. #Martinou from @mocel.bsky.social and collaborators for your latest publication in #Nature #Metabolism 👏 rdcu.be/eASgF
👉 Check #UNIGE press release:
www.unige.ch/medias/en/20...
👉 Check #UNIGE press release:
www.unige.ch/medias/en/20...
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
Arresting mitosis with visible light! Brilliant Victoria von Glasenapp from the Gotta and Winssinger labs @UNIGE develops a cool photo-caged PLK1 inhibitor, which we deploy in 3D spheroids to control mitosis with exquisite spatio-temporal precision. Check out the original article: lnkd.in/eTnzy5Nc
Spatio-temporal control of mitosis using light via a Plk1 inhibitor caged for activity and cellular permeability - Nature Communications
Light is a powerful tool for controlling biological processes. Here, the authors demonstrate its use to modulate inhibitor activity and diffusion, enabling precise control of cell division in multicel...
lnkd.in
February 24, 2025 at 2:11 PM
Arresting mitosis with visible light! Brilliant Victoria von Glasenapp from the Gotta and Winssinger labs @UNIGE develops a cool photo-caged PLK1 inhibitor, which we deploy in 3D spheroids to control mitosis with exquisite spatio-temporal precision. Check out the original article: lnkd.in/eTnzy5Nc
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
Being part of the Pint of Science Geneva team is an absolute blast! 🚀 We’re working hard (and having a little fun too 😁) to bring amazing science talks this 19-21th May.
📌SAVE THE DATE: 19-21 May 2025 🧬
#Science #PintofScience #Geneva
pintofscience.ch
@pintofscience.ch @marinebrunet.bsky.social
📌SAVE THE DATE: 19-21 May 2025 🧬
#Science #PintofScience #Geneva
pintofscience.ch
@pintofscience.ch @marinebrunet.bsky.social
March 20, 2025 at 11:32 AM
Being part of the Pint of Science Geneva team is an absolute blast! 🚀 We’re working hard (and having a little fun too 😁) to bring amazing science talks this 19-21th May.
📌SAVE THE DATE: 19-21 May 2025 🧬
#Science #PintofScience #Geneva
pintofscience.ch
@pintofscience.ch @marinebrunet.bsky.social
📌SAVE THE DATE: 19-21 May 2025 🧬
#Science #PintofScience #Geneva
pintofscience.ch
@pintofscience.ch @marinebrunet.bsky.social
Reposted by MOCEL - Molecular & Cellular Biology Dept - University of Geneva
Having a good time in the LS2 annual meeting @lifesciswitzerland.bsky.social 😊☺️
February 13, 2025 at 2:19 PM
Having a good time in the LS2 annual meeting @lifesciswitzerland.bsky.social 😊☺️