Michael Galperin
@mygalperin.bsky.social
Lead Scientist at the Division of Intramural Research (formerly NCBI), NLM, NIH. Bacterial signaling, c-di-GMP, c-di-AMP, protein domains, COG database
Reposted by Michael Galperin
We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures.
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio
October 16, 2025 at 2:27 PM
We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures.
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio
Reposted by Michael Galperin
Everyone interested in bacterial signal transduction, environmental sensing and motility, don't miss this conference organised by Ariane Briegel @arianebriegel.bsky.social and myself! We have great invited speakers and a number of slots allocated to short talks: www.grc.org/sensory-tran...
2026 Sensory Transduction in Microorganisms Conference GRC
The 2026 Gordon Research Conference on Sensory Transduction in Microorganisms will be held in Ventura, California. Apply today to reserve your spot.
www.grc.org
October 15, 2025 at 6:06 PM
Everyone interested in bacterial signal transduction, environmental sensing and motility, don't miss this conference organised by Ariane Briegel @arianebriegel.bsky.social and myself! We have great invited speakers and a number of slots allocated to short talks: www.grc.org/sensory-tran...
Reposted by Michael Galperin
I want to take a moment to say THANK YOU to Anke Becker and Conrad Mullineaux, our two Editors who retired this past summer. Please check out the article to see all they've done of JB!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 15, 2025 at 8:39 PM
I want to take a moment to say THANK YOU to Anke Becker and Conrad Mullineaux, our two Editors who retired this past summer. Please check out the article to see all they've done of JB!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Michael Galperin
New paper alert! We used our fav technique, genetic suppression, to understand how FimX controls function of the T4P PilB motor ATPase in Pseudomonas aeruginosa. Great collab with the Ellison lab at U Georgia who helped with some fancy microscopy to capture pilus dynamics! doi.org/10.1371/jour...
Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics
Author summary Type IV pili enable Pseudomonas aeruginosa to attach to surfaces, move (twitch), and form biofilms. Pilus extension is powered by the motor protein PilB, which is regulated by other fac...
doi.org
October 13, 2025 at 8:18 PM
New paper alert! We used our fav technique, genetic suppression, to understand how FimX controls function of the T4P PilB motor ATPase in Pseudomonas aeruginosa. Great collab with the Ellison lab at U Georgia who helped with some fancy microscopy to capture pilus dynamics! doi.org/10.1371/jour...
Reposted by Michael Galperin
Happy to share as my first Bluesky post: Our newest paper describing a beautiful example of surprizing evolutionary innovation: Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli | The EMBO Journal www.embopress.org/doi/full/10....
Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli | The EMBO Journal
imageimageChemotaxis receptors typically mediate biased movement of motile bacteria in environmental
gradients by controlling rotation of the flagellar motor. This study identifies a
chemotaxis recept...
www.embopress.org
October 14, 2025 at 11:31 AM
Happy to share as my first Bluesky post: Our newest paper describing a beautiful example of surprizing evolutionary innovation: Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli | The EMBO Journal www.embopress.org/doi/full/10....
Reposted by Michael Galperin
Sneak preview of the next upcoming #SubtiWiki feature: All proteins are assigned to clusters sharing similar structures!
Brought to you by Oskar Geissel and @c-elfmann.bsky.social .
@imprsgs.bsky.social
Brought to you by Oskar Geissel and @c-elfmann.bsky.social .
@imprsgs.bsky.social
October 10, 2025 at 12:23 PM
Sneak preview of the next upcoming #SubtiWiki feature: All proteins are assigned to clusters sharing similar structures!
Brought to you by Oskar Geissel and @c-elfmann.bsky.social .
@imprsgs.bsky.social
Brought to you by Oskar Geissel and @c-elfmann.bsky.social .
@imprsgs.bsky.social
Reposted by Michael Galperin
Differential activation of cGAS in naked mole rats! An exciting addition to our understanding of species-specific mutations tailoring the cGAS-STING pathway in individual organisms
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 9, 2025 at 6:40 PM
Differential activation of cGAS in naked mole rats! An exciting addition to our understanding of species-specific mutations tailoring the cGAS-STING pathway in individual organisms
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Michael Galperin
All science arises only because of the shared broader community. I want to especially recognize Rotem Sorek @soreklab.bsky.social Aude Bernheim @audeber.bsky.social our collaborators and the many wonderful labs and scientists in the field bringing together human and bacterial antiviral research!
October 9, 2025 at 4:44 PM
All science arises only because of the shared broader community. I want to especially recognize Rotem Sorek @soreklab.bsky.social Aude Bernheim @audeber.bsky.social our collaborators and the many wonderful labs and scientists in the field bringing together human and bacterial antiviral research!
Reposted by Michael Galperin
Congratulations to Philip J. Kranzusch, Ph.D., Professor of Cancer Immunology and Virology, who was one of three scientists awarded top honors at the 2025 Blavatnik National Awards for Young Scientists.
Watch to learn more about his work: bit.ly/4pZUDkF
Watch to learn more about his work: bit.ly/4pZUDkF
October 8, 2025 at 5:05 PM
Congratulations to Philip J. Kranzusch, Ph.D., Professor of Cancer Immunology and Virology, who was one of three scientists awarded top honors at the 2025 Blavatnik National Awards for Young Scientists.
Watch to learn more about his work: bit.ly/4pZUDkF
Watch to learn more about his work: bit.ly/4pZUDkF
Reposted by Michael Galperin
Viral AlphaFold Database (VAD) is live in Science Advances
~27,000 predicted viral protein monomers & homodimers
Conserved folds across bacteria, archaea & eukaryotic viruses
New toxin–antitoxin system KreTA uncovered
Vast “functional darkness” remains uncharted
www.science.org/doi/10.1126/...
~27,000 predicted viral protein monomers & homodimers
Conserved folds across bacteria, archaea & eukaryotic viruses
New toxin–antitoxin system KreTA uncovered
Vast “functional darkness” remains uncharted
www.science.org/doi/10.1126/...
The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes
VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.
www.science.org
October 2, 2025 at 8:48 AM
Viral AlphaFold Database (VAD) is live in Science Advances
~27,000 predicted viral protein monomers & homodimers
Conserved folds across bacteria, archaea & eukaryotic viruses
New toxin–antitoxin system KreTA uncovered
Vast “functional darkness” remains uncharted
www.science.org/doi/10.1126/...
~27,000 predicted viral protein monomers & homodimers
Conserved folds across bacteria, archaea & eukaryotic viruses
New toxin–antitoxin system KreTA uncovered
Vast “functional darkness” remains uncharted
www.science.org/doi/10.1126/...
Reposted by Michael Galperin
Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing.
journals.asm.org/doi/10.1128/...
@asm.org
journals.asm.org/doi/10.1128/...
@asm.org
October 7, 2025 at 8:32 PM
Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing.
journals.asm.org/doi/10.1128/...
@asm.org
journals.asm.org/doi/10.1128/...
@asm.org
Two fungal genera use two distinct pathways to synthesize psilocybin
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Dissimilar Reactions and Enzymes for Psilocybin Biosynthesis in Inocybe and Psilocybe Mushrooms
Mushrooms have learned twice independently how to make the iconic magic mushroom natural product psilocybin. This article introduces the enzymes of the second pathway, found in a fiber cap mushroom. ....
onlinelibrary.wiley.com
October 6, 2025 at 1:25 PM
Two fungal genera use two distinct pathways to synthesize psilocybin
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Michael Galperin
Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...
The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature
The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.
www.nature.com
October 1, 2025 at 4:05 PM
Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...
Reposted by Michael Galperin
Reposted by Michael Galperin
Thrilled to be a coauthor in this story 🚀 Check out our latest publication on the archaellum - spoiler: it's an archaellum in bacteria 😱 Who would have thought? Thank you to all the authors, and especially @sshamphavi.bsky.social for really keeping this paper rotating 😉
Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...
Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
www.nature.com/articles/s41...
Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
September 17, 2025 at 5:56 PM
Thrilled to be a coauthor in this story 🚀 Check out our latest publication on the archaellum - spoiler: it's an archaellum in bacteria 😱 Who would have thought? Thank you to all the authors, and especially @sshamphavi.bsky.social for really keeping this paper rotating 😉
Reposted by Michael Galperin
Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...
Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
www.nature.com/articles/s41...
Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
September 17, 2025 at 5:41 PM
Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...
Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
www.nature.com/articles/s41...
Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
Reposted by Michael Galperin
And here is the published version of the work from @selimlab.bsky.social, @mygalperin.bsky.social, Dubnau labs and @thethormannden.bsky.social labs
(superb collaboration)
ComFB, a widespread family of c-di-NMP receptor proteins
www.pnas.org/doi/10.1073/...
(superb collaboration)
ComFB, a widespread family of c-di-NMP receptor proteins
www.pnas.org/doi/10.1073/...
ComFB, a widespread family of c-di-NMP receptor proteins | PNAS
Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates
a variety of cellular processes, including motility, biofil...
www.pnas.org
September 19, 2025 at 11:04 AM
And here is the published version of the work from @selimlab.bsky.social, @mygalperin.bsky.social, Dubnau labs and @thethormannden.bsky.social labs
(superb collaboration)
ComFB, a widespread family of c-di-NMP receptor proteins
www.pnas.org/doi/10.1073/...
(superb collaboration)
ComFB, a widespread family of c-di-NMP receptor proteins
www.pnas.org/doi/10.1073/...
Reposted by Michael Galperin
Registration is open! Come join us at the sensory transduction in microorganisms GRC! Spread the word! www.grc.org/sensory-tran...
2026 Sensory Transduction in Microorganisms Conference GRC
The 2026 Gordon Research Conference on Sensory Transduction in Microorganisms will be held in Ventura, California. Apply today to reserve your spot.
www.grc.org
September 12, 2025 at 6:05 AM
Registration is open! Come join us at the sensory transduction in microorganisms GRC! Spread the word! www.grc.org/sensory-tran...
Reposted by Michael Galperin
Some thoughts on metabolism and metabolic pathway holes (PMID: 40892933)
pnas.org/doi/10.1073/....
pnas.org/doi/10.1073/....
Using bioinformatics for identifying and plugging metabolic pathway holes | PNAS
Using bioinformatics for identifying and plugging metabolic pathway holes
pnas.org
September 2, 2025 at 8:53 PM
Some thoughts on metabolism and metabolic pathway holes (PMID: 40892933)
pnas.org/doi/10.1073/....
pnas.org/doi/10.1073/....
Reposted by Michael Galperin
Prioritising Microbiology in Secondary Education Addresses Emerging Scientific-Social-Educational Challenges and Competency Needs
#MicrobialBiotech by Lara Amorim, Conceição Santos, and Kenneth Timmis
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
#MicrobialBiotech by Lara Amorim, Conceição Santos, and Kenneth Timmis
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
Prioritising Microbiology in Secondary Education Addresses Emerging Scientific‐Social‐Educational Challenges and Competency Needs
This work highlights how microbiology education can empower secondary school students with critical and systems thinking, fostering STEM literacy, overcoming barriers and preparing informed, responsi...
enviromicro-journals.onlinelibrary.wiley.com
September 1, 2025 at 9:44 AM
Prioritising Microbiology in Secondary Education Addresses Emerging Scientific-Social-Educational Challenges and Competency Needs
#MicrobialBiotech by Lara Amorim, Conceição Santos, and Kenneth Timmis
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
#MicrobialBiotech by Lara Amorim, Conceição Santos, and Kenneth Timmis
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...