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selimlab.bsky.social
Khaled_Selim Lab
@selimlab.bsky.social
310 followers 280 following 180 posts
Microbiology | Cell Signaling | Structural Biology | Institute of Phototrophic Microbiology @hhu.de
https://www.phototrophic-microbiology.hhu.de/en/

Central Metabolism Coordination by #PII & #cdiAMP & #cdiGMP & #Ca2+ signaling #Cyanobacteria
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selimlab.bsky.social
Khaled_Selim Lab @selimlab.bsky.social · Sep 19
We discovered a new family of c-di-NMP receptors, widespread in bacteria & regulating🦠motility @pnas.org

A great collab. w/ @mygalperin.bsky.social @vikramalva.bsky.social @thethormannden.bsky.social

www.pnas.org/doi/10.1073/...

@hhu.de @cmfi.bsky.social
@sfb1381.bsky.social
@mibinet.bsky.social
Reposted by Khaled_Selim Lab
plantsciencedbg.bsky.social
New AI tool “Helixer” identifies genes in newly sequenced organisms. Helixer identifies genes directly from DNA sequences.

Developed by team around @usadellab.bsky.social @fz-juelich.de, @apmweber.bsky.social , @sebtriesch.bsky.social @hhu.de et al. www.fz-juelich.de/en/news/arch...
AI tool “Helixer” identifies genes in newly sequenced organisms
Researchers at Forschungszentrum Jülich and Heinrich Heine University Düsseldorf have developed a tool that could significantly transform genome research: Helixer identifies genes directly from DNA se...
www.fz-juelich.de
January 26, 2026 at 6:04 PM
Reposted by Khaled_Selim Lab
plantphys.bsky.social
PII interactions with the acetyl-CoA carboxylase subunits BADC and BCCP co-regulate lipid and nitrogen metabolism in Arabidopsis (Matthew G Garneau , Gabriel Lemes Jorge , Jay Shockey , Jay J Thelen , Philip D Bates) doi.org/10.1093/plph... #PlantScience @aspbofficial
PII interactions with the acetyl-CoA carboxylase subunits BADC and BCCP co-regulate lipid and nitrogen metabolism in Arabidopsis
The PII protein regulates fatty acid synthesis and through interactions with biotin/lipoyl attachment domain containing and biotin carboxyl carrier protein
doi.org
January 26, 2026 at 6:57 PM
Reposted by Khaled_Selim Lab
scisonja.bsky.social
WE ARE #HIRING: [reposting=👌 🙏 ]
2 funded positions for #nanopore related projects @unibas.ch 🇨🇭:
1️⃣ #PhD Candidate in Single-Molecule Biophysics using Nanopore Trapping.
2️⃣ #PhD Candidate in Microplastic Detection Using Micropores and Microfluidics.
More info: schmid.chemie.unibas.ch/en/join-us-1/
January 23, 2026 at 7:23 PM
Reposted by Khaled_Selim Lab
labwaggoner.bsky.social
How did eukaryotic cells with complex architecture evolve from simpler prokaryotic cells? DNA analyses offer possible answers @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41... @bristoluni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genomic clues to the origin of eukaryotic cells
How did eukaryotic cells with complex architecture evolve from simpler prokaryotic cells? DNA analyses offer possible answers.
www.nature.com
January 15, 2026 at 4:43 PM
selimlab.bsky.social
www.ufz.de/index.php?en...
Here ist a small press about our recent findings about Guanidin metabolism in #cyanobacteria

Toxicity vs. Uptake & Catabolism

A great collaboration between @ufz.de & @hhu.de & @unihalle.bsky.social

HERE is the original publication @pnas.org
www.pnas.org/doi/10.1073/...
January 15, 2026 at 5:59 PM
selimlab.bsky.social
New enzyme with dual function as methionine synthase and a glycine betaine methyltransferase

Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria

www.pnas.org/doi/full/10....
January 14, 2026 at 9:37 AM
Reposted by Khaled_Selim Lab
sander1507.bsky.social
We Are very happy that our Paper was published. Thank to everyone involved

pubs.acs.org/doi/10.1021/...

@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
A Novel Biosensor for Ferrous Iron Developed via CoBiSe: A Computational Method for Rapid Biosensor Design
Genetically encoded biosensors enable the monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational biosensor design approach using Constraint Network Analysis to ident...
pubs.acs.org
January 12, 2026 at 9:48 AM
Reposted by Khaled_Selim Lab
frunzkelab.bsky.social
Happy to share our recent preprint:
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"

www.biorxiv.org/content/10.6...

@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
January 14, 2026 at 8:57 AM
Reposted by Khaled_Selim Lab
thanbichlerlab.bsky.social
Ancestral sequence reconstruction reveals CTP-dependent loading of the bacterial centromere-binding protein ParB as an ancient evolutionary feature

Now published:
tinyurl.com/4ddhwbb3

Thanks to the Hochberg and Bange labs for the great collaboration!
January 9, 2026 at 7:44 PM
Reposted by Khaled_Selim Lab
stallingslab.bsky.social
We are hiring new faculty!! Come join our amazing community in the Department of Molecular Microbiology at Washington University School of Medicine! The deadline for applications is 2/21, but applications will be reviewed on a rolling basis. facultyopportunities.wustl.edu/Posting/Deta...
Opportunity Details - Faculty Opportunities
facultyopportunities.wustl.edu
January 8, 2026 at 9:05 PM
Reposted by Khaled_Selim Lab
molmicrounihoh.bsky.social
🫴 Genetic switch between unicellularity and multicellularity in marine yeasts:

www.nature.com/articles/s41...

@nature.com
Client Challenge
www.nature.com
January 8, 2026 at 3:11 PM
Reposted by Khaled_Selim Lab
stallingslab.bsky.social
Registration is open for the 2026 Gordon Research Conference on Microbial Stress Response to be held on July 19-24 2026!! Submit your abstract by February 15th to be considered for a short talk. Apply now before it fills up!! Hope to see you there!! www.grc.org/microbial-st...
2026 Microbial Stress Response Conference GRC
The 2026 Gordon Research Conference on Microbial Stress Response will be held in South Hadley, Massachusetts. Apply today to reserve your spot.
www.grc.org
January 6, 2026 at 7:15 PM
Reposted by Khaled_Selim Lab
vinceconticello.bsky.social
New manuscript alert. Turns out that calcium ion coordination may be a more common mechanism than we initially expected to trigger polymerization of extracellular filaments. @mikesleutel.bsky.social @vikramalva.bsky.social

www.biorxiv.org/content/10.6...
From fibril to framework: P. abyssi AbpX illuminates a calcium-responsive family of microbial biomatrix proteins that form thermostable hydrogels
Evolutionary pressure on microbial communities propagating under extreme environmental conditions often results in unique structural adaptations to promote cell survival. Here, we report an investigat...
www.biorxiv.org
January 5, 2026 at 3:02 PM
Reposted by Khaled_Selim Lab
jcb.org
Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/...

#CryoET
January 5, 2026 at 8:15 PM
Reposted by Khaled_Selim Lab
dplamartin.bsky.social
Are you interested in a postdoctoral position? Do you have experience in mitochondrial biology and in vivo research? Please send me your CV!
January 5, 2026 at 1:25 PM
Reposted by Khaled_Selim Lab
curiousdina.bsky.social
A new year brings new opportunities: we are looking to fill a permanent professorship position with a Microbiologist preferably with expertise on archaeal biology, RNA biology or imaging techniques to unravel cell biology in prokaryotes! Please share and/or apply :)! www.nature.com/naturecareer...
Professurship (W2) in Microbiology - Regensburg (Stadt), Bayern (DE) job with Universität Regensburg | 12851113
UNIVERSITY OF REGENSBURG   The Faculty of Biology and Pre-Clinical Medicine invites applications for a   Professurship (W2) in Microbiology   To be...
www.nature.com
January 5, 2026 at 9:46 AM
Reposted by Khaled_Selim Lab
pbernalt6ss.bsky.social
We are starting 2026 by looking for candidates to apply for the Junta de Andalucía PhD fellowship. If you are interested in bacterial secretion systems and molecular biology, get in touch. More info about our work: personal.us.es/pbguzman/ & regarding the call www.investigacion.us.es/convocatoria...
January 4, 2026 at 6:50 PM
Reposted by Khaled_Selim Lab
quantamagazine.bsky.social
A balance of infection and harmony called endosymbiosis helps shape evolution. For the first time, biologists have reproduced this arrangement between microbes in a lab.
Scientists Re-Create the Microbial Dance That Sparked Complex Life | Quanta Magazine
Evolution was fueled by endosymbiosis, cellular alliances in which one microbe makes a permanent home inside another. For the first time, biologists made it happen in the lab.
www.quantamagazine.org
December 31, 2025 at 4:46 PM
Reposted by Khaled_Selim Lab
hellmichgroup.bsky.social
🧪HAPPY 2026 EVERYONE!!!! 🥂🍾🥳

When you enjoy your bubbly this evening, do spare a thought about carbonic anhydrase - it's an amazing enzyme (almost as fast as 2025 felt! 😜), and it turns out, it's also responsible for tasting CO2's "fizziness"!!! 🍾

www.science.org/doi/10.1126/...
The Taste of Carbonation
The enzyme carbonic anhydrase mediates the taste sensation of carbonated drinks.
www.science.org
December 31, 2025 at 12:56 PM
Reposted by Khaled_Selim Lab
kevincorbett.bsky.social
Congratulations to Doi Basu @dwaipayanbasu.bsky.social for publishing his first first-author paper from the lab!
The cryoEM structure of a tubulin-like protein from bacteriophage Goslar forms "microtubules" with nine protofilaments!
authors.elsevier.com/a/1mM253SNvc...
authors.elsevier.com
December 30, 2025 at 5:35 AM
Reposted by Khaled_Selim Lab
arcadiascience.com
A free, open-access library of high-quality organism illustrations for science communication
A free, open-access library of high-quality organism illustrations for science communication
We create vector graphics of model organisms and emerging biological research organisms to enhance our publications. We’re sharing these editable graphics under a CC0 license for other scientists to...
doi.org
December 29, 2025 at 6:03 PM
Reposted by Khaled_Selim Lab
curiousdina.bsky.social
Thanks to all who provide these illustrations for free - it helps so much for teaching etc! It’s like a Christmas present again and again ☺️
December 30, 2025 at 7:20 AM
Reposted by Khaled_Selim Lab
thethormannden.bsky.social
Old and mighty: A novel cytosine nucleobase modification in phage genomic DNA renders the majority of restriction-based host defence systems useless. Great collaboration with the Bielefeld Gang. | Applied and Environmental Microbiology journals.asm.org/doi/10.1128/...
A pentose, as a cytosine nucleobase modification in Shewanella phage Thanatos genomic DNA, mediates enhanced resistance toward host restriction systems | Applied and Environmental Microbiology
Several phages extensively decorate their DNA building blocks, providing an effective protection against various host and phage-produced restriction systems. These modifications allow the phages to di...
journals.asm.org
December 29, 2025 at 9:44 AM
Reposted by Khaled_Selim Lab
molecularmicro.bsky.social
Tiffany Zarrella et al. provide new insights into the role of the bacterial second messenger cyclic di-adenosine monophosphate (c-di-AMP) in maintaining cell envelope homeostasis in Streptococcus pneumoniae.
#MicroSky #cyclic-di-AMP
onlinelibrary.wiley.com/doi/10.1111/...
Cyclic Di‐AMP Affects Cell Membrane Integrity of Streptococcus pneumoniae
When Streptococcus pneumoniae produces low amounts of the second messenger cyclic di-AMP (c-di-AMP), they do not survive in the presence of competence-stimulating peptide (CSP), which is used for tra...
onlinelibrary.wiley.com
July 2, 2025 at 3:01 PM
Reposted by Khaled_Selim Lab
labwaggoner.bsky.social
In Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense
rupress.org/jem/article-... @jem.org
December 28, 2025 at 4:46 AM