Nucleic Acids Research
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Nucleic Acids Research
@narjournal.bsky.social
Nucleic Acids Research (NAR), from Oxford University Press, publishes the results of leading-edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions
⭐NAR Breakthrough ⭐
New study identifies a 6-nt miR-17 site in the #PKD1 3′UTR that limits PKD1 expression. Targeting this site boosts PKD1 protein and reduces cyst burden in #ADPKD models—highlighting a promising oligo-based strategy @vishal-d-patel.bsky.social
🧬Read more: doi.org/10.1093/nar/...
January 21, 2026 at 2:14 PM
⭐NAR Breakthrough! ⭐
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough
January 19, 2026 at 6:23 PM
🌟 2026 Nucleic Acids Research Database issue 🧬
182 papers, 84 new databases, plus Breakthrough Articles on JoGo (global long‑read haplotypes) and So3D (3D spatial genomics). Browse the issue and Editorial: academic.oup.com/nar/issue/54...
academic.oup.com/nar/article/...
@danielrigden.bsky.social
January 19, 2026 at 9:06 AM
⭐NAR Breakthrough! ⭐

🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival.
🧬Read more: doi.org/10.1093/nar/...
December 23, 2025 at 4:03 PM
👏 Congratulations to @helena-stafflinger.bsky.social Helena Stafflinger, @en-hxnu-enment.bsky.social Hermann Schindelin, Jens Wöhnert and their team on this elegant and paradigm-shifting study uncovering unexpected principles of RNA G-quadruplex formation! @uniinnsbruck.bsky.social
December 22, 2025 at 3:48 PM
⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...

#NARBreaktrhough #RNA #StructuralBiology
December 22, 2025 at 3:48 PM
🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis
December 15, 2025 at 4:25 PM
⭐ NAR Breakthrough! ⭐
🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back!
🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity.
🧬 Read more: doi.org/10.1093/nar/...
November 25, 2025 at 5:10 PM
⭐ NAR Breakthrough! ⭐
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
November 24, 2025 at 6:16 PM
⭐ NAR Breakthrough! ⭐

🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough
November 21, 2025 at 6:18 PM
⭐ NAR Breakthrough! ⭐

A community-driven collection uniting 52 phages, 74 Klebsiella isolates, and extensive genomic + phenotypic data — all freely available at klebphacol.org.
🧬 Learn more: doi.org/10.1093/nar/...
@fnobrega.bsky.social @danielarothschild.bsky.social #antimicrobialresistance
November 20, 2025 at 6:01 PM
📣 Authors wanted! Submit to NARMME's Special Collection on Repeat Expansion Diseases by Jan 2026🧬

🔍Find out more: academic.oup.com/narmolmed/pa...

👉Submit: mc.manuscriptcentral.com/narmme

#CallForPapers #Genomics #RareDiseases #NARMME
October 30, 2025 at 10:28 AM
🧬 New in NARGAB: A fast, scalable CHT method identifies genomic regions with shared effects across traits. Applied to psychiatric pleiotropy and cucumber virus resistance.

Read: doi.org/10.1093/narg...

#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics
October 16, 2025 at 3:45 PM
🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
October 16, 2025 at 3:41 PM
⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org

#NARbreakthrough #ChromosomeSegregation
October 15, 2025 at 1:49 PM
Five years ago, Dr. Doudna @jenniferdoudna.bsky.social and Dr. Charpentier won the #NobelPrize for #CRISPR/Cas9, revolutionizing gene editing and science as we know it. 🎉🎉Celebrate this milestone with our #specialcollections academic.oup.com/nar/pages/cr... and academic.oup.com/nar/pages/cr...
October 7, 2025 at 5:48 AM
🧬 New in NARGAB: authors compared human exome sequencing kits, showing how design differences impact capture efficiency and downstream analysis. Useful insights for choosing the right kit!

📖 Read: doi.org/10.1093/narg...

#ExomeSequencing #Genomics #Bioinformatics #NARGAB
September 22, 2025 at 2:19 PM
🧬New in NARGAB: a composite hypothesis testing (CHT) method to find genetic regions affecting multiple traits is described which is efficient, scalable and applied to psychiatric disorders and viral resistance in cucumber.

Read here: doi.org/10.1093/narg...

#Genomics #CHT #Bioinformatics #NARGAB
September 22, 2025 at 2:16 PM
🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.

📖 Read more: lnkd.in/eahrVbMt

#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
September 19, 2025 at 5:04 PM
💡 New in NARMME: TRL1 enzyme from Candida glabrata changes shape to control RNA repair, vital for fungal survival. Its absence in humans makes it a promising antifungal drug target.

📖 Read more: doi.org/10.1093/narm...

#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess
September 18, 2025 at 4:56 PM
🔬 New study in NARMME explores how azvudine (FNC) targets HIV-1 RT & SARS-CoV-2 RdRp🧬

📖 doi.org/10.1093/narm...

#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication
September 18, 2025 at 4:47 PM
💡A new RNAi strategy described in NARMME embeds miR-based shRNAs into a gamma-retroviral intron, enabling gene knockdown and protein coexpression with high viral titers.

📖 doi.org/10.1093/narm...

#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication
September 15, 2025 at 1:33 PM
🧬 A new review in NARMME explores how chromatin preserves cell identity and how its breakdown may drive diseases like neurodegeneration and cancer.

📖 doi.org/10.1093/narm...

#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine
September 15, 2025 at 1:11 PM
🐟 New in NARMME: malat1 in zebrafish triggers signaling for retinal repair guided by Notch, Wnt & TGF-β pathways. In mammals, TGF-β blocks regeneration revealing a key difference in healing potential.

🔗 doi.org/10.1093/narm...

#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess
September 12, 2025 at 11:31 AM
🦟 New in NARMME: for the first time, microRNA in tsetse fly saliva carrying Trypanosoma brucei were profiled. Infected flies carry less diverse microRNAs, hinting roles in how the disease spreads.

🔗 doi.org/10.1093/narm...

#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess
September 12, 2025 at 11:26 AM