New study identifies a 6-nt miR-17 site in the #PKD1 3′UTR that limits PKD1 expression. Targeting this site boosts PKD1 protein and reduces cyst burden in #ADPKD models—highlighting a promising oligo-based strategy @vishal-d-patel.bsky.social
🧬Read more: doi.org/10.1093/nar/...
New study identifies a 6-nt miR-17 site in the #PKD1 3′UTR that limits PKD1 expression. Targeting this site boosts PKD1 protein and reduces cyst burden in #ADPKD models—highlighting a promising oligo-based strategy @vishal-d-patel.bsky.social
🧬Read more: doi.org/10.1093/nar/...
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough
182 papers, 84 new databases, plus Breakthrough Articles on JoGo (global long‑read haplotypes) and So3D (3D spatial genomics). Browse the issue and Editorial: academic.oup.com/nar/issue/54...
academic.oup.com/nar/article/...
@danielrigden.bsky.social
182 papers, 84 new databases, plus Breakthrough Articles on JoGo (global long‑read haplotypes) and So3D (3D spatial genomics). Browse the issue and Editorial: academic.oup.com/nar/issue/54...
academic.oup.com/nar/article/...
@danielrigden.bsky.social
🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival.
🧬Read more: doi.org/10.1093/nar/...
🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival.
🧬Read more: doi.org/10.1093/nar/...
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
#NARBreakthrough #RibosomeBiogenesis
#NARBreakthrough #RibosomeBiogenesis
🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back!
🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity.
🧬 Read more: doi.org/10.1093/nar/...
🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back!
🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity.
🧬 Read more: doi.org/10.1093/nar/...
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough
🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough
A community-driven collection uniting 52 phages, 74 Klebsiella isolates, and extensive genomic + phenotypic data — all freely available at klebphacol.org.
🧬 Learn more: doi.org/10.1093/nar/...
@fnobrega.bsky.social @danielarothschild.bsky.social #antimicrobialresistance
A community-driven collection uniting 52 phages, 74 Klebsiella isolates, and extensive genomic + phenotypic data — all freely available at klebphacol.org.
🧬 Learn more: doi.org/10.1093/nar/...
@fnobrega.bsky.social @danielarothschild.bsky.social #antimicrobialresistance
🔍Find out more: academic.oup.com/narmolmed/pa...
👉Submit: mc.manuscriptcentral.com/narmme
#CallForPapers #Genomics #RareDiseases #NARMME
🔍Find out more: academic.oup.com/narmolmed/pa...
👉Submit: mc.manuscriptcentral.com/narmme
#CallForPapers #Genomics #RareDiseases #NARMME
Read: doi.org/10.1093/narg...
#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics
Read: doi.org/10.1093/narg...
#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
📖 Read: doi.org/10.1093/narg...
#ExomeSequencing #Genomics #Bioinformatics #NARGAB
📖 Read: doi.org/10.1093/narg...
#ExomeSequencing #Genomics #Bioinformatics #NARGAB
Read here: doi.org/10.1093/narg...
#Genomics #CHT #Bioinformatics #NARGAB
Read here: doi.org/10.1093/narg...
#Genomics #CHT #Bioinformatics #NARGAB
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
📖 Read more: doi.org/10.1093/narm...
#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess
📖 Read more: doi.org/10.1093/narm...
#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess
📖 doi.org/10.1093/narm...
#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication
📖 doi.org/10.1093/narm...
#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication
📖 doi.org/10.1093/narm...
#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication
📖 doi.org/10.1093/narm...
#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication
📖 doi.org/10.1093/narm...
#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine
📖 doi.org/10.1093/narm...
#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine
🔗 doi.org/10.1093/narm...
#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess
🔗 doi.org/10.1093/narm...
#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess
🔗 doi.org/10.1093/narm...
#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess
🔗 doi.org/10.1093/narm...
#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess