Naveen Jain
@naveen-jain.bsky.social
Future physician-scientist in internal medicine and incoming intern @UCSF | @UPenn '25 | @WashU '16 | functional genomics, lineage tracing, rare cell biology
1/ Really neat case I helped with on my inpatient hematology rotation at @pennmedicine.bsky.social. Won't say too much to avoid spoilers, but definitely a head scratcher. Thank you to everybody who helped care for her and also Dr. Caren Solomon and @nejm.org for a constructive revision process!
A 37-year-old woman presented with a 4-day history of pain, swelling, and bruising on the upper portion of her left knee after using a massage gun. She reported no other bruising or bleeding apart from chronic menorrhagia. Read the full case details: nej.md/3HHMwrP
#MedSky
#MedSky
September 9, 2025 at 5:06 AM
1/ Really neat case I helped with on my inpatient hematology rotation at @pennmedicine.bsky.social. Won't say too much to avoid spoilers, but definitely a head scratcher. Thank you to everybody who helped care for her and also Dr. Caren Solomon and @nejm.org for a constructive revision process!
Reposted by Naveen Jain
Excited and grateful that our initial report on temperature-sensitive protein switches is now published
@naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social
www.nature.com/articles/s41...
Brief thread:
@naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social
www.nature.com/articles/s41...
Brief thread:
January 24, 2025 at 11:53 AM
Excited and grateful that our initial report on temperature-sensitive protein switches is now published
@naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social
www.nature.com/articles/s41...
Brief thread:
@naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social
www.nature.com/articles/s41...
Brief thread:
Reposted by Naveen Jain
Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Multiscale footprints reveal the organization of cis-regulatory elements - Nature
We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.
www.nature.com
January 23, 2025 at 2:11 AM
Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Apparently cancer cells can pass defective mitochondria, effectively a metabolic poison, onto T cells as a mechanism of immune evasion. Who knew! Importantly, specific mtDNA mutations also predict poor clinical response to immune checkpoint inhibitors. www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 23, 2025 at 8:58 PM
Apparently cancer cells can pass defective mitochondria, effectively a metabolic poison, onto T cells as a mechanism of immune evasion. Who knew! Importantly, specific mtDNA mutations also predict poor clinical response to immune checkpoint inhibitors. www.nature.com/articles/s41...
Just saw Ricardo Mallarino present his lab's innovative work on uncovering the molecular mechanisms of developmental programs driving biological diversity in a number of nonconventional model organisms. This study in particular in sugar gliders blew my mind!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Emx2 underlies the development and evolution of marsupial gliding membranes - Nature
Patagia—the mammalian gliding membrane—repeatedly originated through a process of convergent genomic evolution, whereby the regulation of Emx2 was altered by distinct cis-regulatory elements in indepe...
www.nature.com
January 17, 2025 at 10:28 PM
Just saw Ricardo Mallarino present his lab's innovative work on uncovering the molecular mechanisms of developmental programs driving biological diversity in a number of nonconventional model organisms. This study in particular in sugar gliders blew my mind!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Naveen Jain
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 15, 2025 at 8:32 PM
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Naveen Jain
Excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops: are generally rare (2.3%)
www.biorxiv.org/content/10.1...
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops:
www.biorxiv.org/content/10.1...
January 16, 2025 at 1:35 PM
Excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops: are generally rare (2.3%)
www.biorxiv.org/content/10.1...
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops:
www.biorxiv.org/content/10.1...