Nate Basisty (he/him)
nbasisty.bsky.social
Nate Basisty (he/him)
@nbasisty.bsky.social
Happy to share our lab’s latest paper in Analytical Chemistry! pubmed.ncbi.nlm.nih.gov/41084887/

Our first foray into top-down proteomics led by Dr. Mozhgan Boroumand sought to identify proteoforms of the Senescent Secretome (SASP)-a stepping stone toward human proteoform biomarker candidates. 1/n
Characterization of the Intact Proteomic Profile of Senescent-Associated Secretory Phenotype by Top-Down Mass Spectrometry - PubMed
Cellular senescence is a stable state of cell-cycle arrest characterized by extensive remodeling of the secretome, known as the senescence-associated secretory phenotype (SASP). The SASP profoundly influences tissue microenvironments and contributes to chronic inflammation and age-related diseases. …
pubmed.ncbi.nlm.nih.gov
November 19, 2025 at 11:20 AM
Reposted by Nate Basisty (he/him)
Super exiting! What could be better than winning an award? Winning in the same year as a former UW trainee (Nate), one of my closest colleagues (Bill), and two good friends (Neil and Lingjun). See you all in St. Louis!
🎉 Huge congratulations to the five incredible winners of the 2026 US HUPO Association Awards! 🏆 We're so excited to celebrate your achievements at US HUPO 2026 in St. Louis! #USHUPO2026 #USHUPO
November 15, 2025 at 12:11 AM
Huge honor to be recognized by @us-hupo.org! Congratulations to the truly deserving winners - @maccoss.bsky.social, William Noble, @nlkproteomics.bsky.social, Lingjun Li! #USHUPO2026 #USHUPO
🎉 Huge congratulations to the five incredible winners of the 2026 US HUPO Association Awards! 🏆 We're so excited to celebrate your achievements at US HUPO 2026 in St. Louis! #USHUPO2026 #USHUPO
November 19, 2025 at 11:07 AM
Reposted by Nate Basisty (he/him)
Join the #USHUPO2026 scientific program by submitting an abstract. Network with experts, gain visibility, and contribute to advancing proteomics.

Submission site CLOSES TOMORROW!
Learn more: www.ushupoconference.org
November 18, 2025 at 11:01 PM
Reposted by Nate Basisty (he/him)
Save the date 🙌
Learn how to prepare for conferences with intention, maximize learning and engagement during the event, and build lasting professional connections that support long-term career growth in this 70-minute session.

Register Now: tinyurl.com/4pz2yjwt
September 11, 2025 at 4:33 PM
Reposted by Nate Basisty (he/him)
Here we go, my first skeet-torial(?) on Bluesky for my first paper from @talusbio.bsky.social !

www.biorxiv.org/content/10.1...

This preprint describes our scalable, mass spec-based method for measuring which (and how many of them) proteins are interacting with DNA.

1/?
Native, Spatiotemporal Profiling of the Global Human Regulome
The regulome, comprising transcription factors, cofactors, chromatin remodelers, and other regulatory proteins, forms the core machinery by which cells interpret signals and execute gene expression pr...
www.biorxiv.org
July 2, 2025 at 3:08 PM
Where are the deep proteomic studies of mouse blood? We rarely see them because doing proteomics in mouse blood is challenging due to volume limitations and dynamic range.

I’m pleased to share our latest preprint showing a workflow that overcomes these challenges.

shorturl.at/hMpV6

1/n
Deep and Quantitative Proteomic Profiling of Low Volume Mouse Serum Across the Lifespan
Assessing and validating circulating biomarkers is essential for the development of pre-clinical biomarkers that predict biological aging and aging-phenotypes in mice. However, comprehensive proteomic...
www.biorxiv.org
July 2, 2025 at 4:47 PM
Reposted by Nate Basisty (he/him)
We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And the leads to a unified model to put it all together. (open-access)
erictopol.substack.com/p/the-driver...
June 8, 2025 at 6:52 PM
Check out the latest in aging proteomics from NIA at #ASMS2025! Please stop by and chat with our talented team! @bradolinger.bsky.social @reemabanarjee.bsky.social

Welcome to Baltimore, excited to have our mass spec colleagues and friends on our turf.
May 28, 2025 at 1:02 PM
Reposted by Nate Basisty (he/him)
Don't Miss Out - TOMORROW - it's an interactive proteomics seminar series!

The CNPN x US HUPO Spotlight Series Webinar brings you cutting edge proteomics research from leading Canadian and US scientist.

Register NOW: ow.ly/lSY150VNhpI
May 26, 2025 at 6:28 PM
Reposted by Nate Basisty (he/him)
Attending #ASMS2025 in Baltimore? Interested in quantitative proteomics? Join us Sunday Afternoon, June 1st for our annual Skyline User Group Meeting. We have a fantastic group of speakers. For information and to Register:
skyline.ms/project/home...
#massspectrometry #proteomics #metabolomics
Start Page: /home/software/Skyline/events/2025 User Group Meeting at ASMS
skyline.ms
May 5, 2025 at 6:41 AM
#ASMS2025 is basically in my back yard this year!! Looking forward to reconnecting with friends and showcasing the latest from NIA after a bit of a break from conferences.

Happy to show off some fun neighborhoods (Fells, Fed Hill, etc) for #teammassspec- all pretty walkable. Hit me up!
May 20, 2025 at 7:00 PM
Reposted by Nate Basisty (he/him)
Register Now! CNPN x US HUPO Spotlight Series seminar on cutting-edge proteomics research. Meet leading scientists from Canada and the US and learn how proteomics is changing the way we think about fungal disease and epigenetic mechanisms in human disease.

zoom.us/meeting/regi...
May 20, 2025 at 6:17 PM
Reposted by Nate Basisty (he/him)
Check out our upcoming webinar! In this US HUPO X ABRF crossover event, you'll learn about where AI is currently used in proteomics and where it may be transformative in the future. Register now: ow.ly/tKB750VB1PN 🧪
April 16, 2025 at 6:00 PM