Lindsay K Pino
@lindsaykpino.com
#massspectrometry, #proteomics, and #bioinformatics | hiking and dogs | co-founder & CTO @talusbio | opinions my own
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Lindsay K Pino
@lindsaykpino.com
· Sep 27
Hello! 👋 Most of you are friends from Twitter/X already, but for those new connections, a brief intro:
I'm a #massspectrometry #proteomic scientist 👩🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/
I'm a #massspectrometry #proteomic scientist 👩🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/
Reposted by Lindsay K Pino
We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below:
(TLDR; low-affinity motifs matter as pioneers!)
(TLDR; low-affinity motifs matter as pioneers!)
Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs
Low-affinity transcription factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our a...
www.biorxiv.org
November 19, 2025 at 8:57 PM
We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below:
(TLDR; low-affinity motifs matter as pioneers!)
(TLDR; low-affinity motifs matter as pioneers!)
Reposted by Lindsay K Pino
This is our loading buffer on our Exploris 480 /U3000 system today. Coming to Nature Methods ASAP: The Proteomics S.P.I.D.E.R. Method (Suitability Protocol Integrating Dead Eight-legged Reference)
December 2, 2025 at 10:18 PM
This is our loading buffer on our Exploris 480 /U3000 system today. Coming to Nature Methods ASAP: The Proteomics S.P.I.D.E.R. Method (Suitability Protocol Integrating Dead Eight-legged Reference)
Small thread on biotech in Seattle before I head out to Boston:
Sentiments in WA life science startup scene = very disappointed in the lack of SBIR renewal to fuel good startup ideas/commercialization efforts, and the number of clinical trials moving from the US to China, Australia, Canada.
Sentiments in WA life science startup scene = very disappointed in the lack of SBIR renewal to fuel good startup ideas/commercialization efforts, and the number of clinical trials moving from the US to China, Australia, Canada.
December 3, 2025 at 1:16 AM
Small thread on biotech in Seattle before I head out to Boston:
Sentiments in WA life science startup scene = very disappointed in the lack of SBIR renewal to fuel good startup ideas/commercialization efforts, and the number of clinical trials moving from the US to China, Australia, Canada.
Sentiments in WA life science startup scene = very disappointed in the lack of SBIR renewal to fuel good startup ideas/commercialization efforts, and the number of clinical trials moving from the US to China, Australia, Canada.
Every year, I aspire to complete the #AdventOfCode, and every year, I lose focus within three days. Wonder how far I'll make it this year
adventofcode.com
adventofcode.com
Advent of Code 2025
adventofcode.com
December 1, 2025 at 6:18 PM
Every year, I aspire to complete the #AdventOfCode, and every year, I lose focus within three days. Wonder how far I'll make it this year
adventofcode.com
adventofcode.com
Reposted by Lindsay K Pino
Our Ultra2 has a Peak Genius on it. It is compressing(?) every 3-5 seconds with Captivespray. Anyone else have this same setup and know if this normal? It seems weird.
December 1, 2025 at 4:05 PM
Our Ultra2 has a Peak Genius on it. It is compressing(?) every 3-5 seconds with Captivespray. Anyone else have this same setup and know if this normal? It seems weird.
Reposted by Lindsay K Pino
Woo! Congrats @olgavitek.bsky.social , @dschweppe.bsky.social , Sasha, and Hanno!
We are thrilled to announce our 2026 election results. Olga Vitek has been elected to serve as US HUPO's President-Elect, Devin Schweppe as Secretary, and Sasha Singh and Hanno Steen were elected to serve as Members-At-Large on our Board of Directors. Congratulations to all! 🌟 #USHUPO
December 1, 2025 at 4:17 PM
Woo! Congrats @olgavitek.bsky.social , @dschweppe.bsky.social , Sasha, and Hanno!
Reposted by Lindsay K Pino
UNCW's Dept of Chem and Biochem is looking for four (4!) new members this cycle including:
Asst Professor Analytical Chem
Asst Professor Physical Chem
Lecturer - Bio- and general Chem
Lecturer - General Chem
Our dept is a great place to work and Wilmington's a blast!
#ChemSky #ChemJobs
Links ⬇️
Asst Professor Analytical Chem
Asst Professor Physical Chem
Lecturer - Bio- and general Chem
Lecturer - General Chem
Our dept is a great place to work and Wilmington's a blast!
#ChemSky #ChemJobs
Links ⬇️
November 25, 2025 at 2:01 AM
Reposted by Lindsay K Pino
Have any #proteomics information analysis systems been developed that try to explain experimental results in terms of transcription factors & E3 ligases rather than metabolic/functional pathways?
November 29, 2025 at 3:56 PM
Have any #proteomics information analysis systems been developed that try to explain experimental results in terms of transcription factors & E3 ligases rather than metabolic/functional pathways?
Reposted by Lindsay K Pino
I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:
November 29, 2025 at 5:41 PM
I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:
Reposted by Lindsay K Pino
Reading papers over the weekend, I realised how often the term gene network is misused. Please refrain from using it unless you have clear, functional evidence of causal interactions between transcription factors. Otherwise, what you have are (at best) correlations. Just saying....
November 29, 2025 at 1:15 PM
Reading papers over the weekend, I realised how often the term gene network is misused. Please refrain from using it unless you have clear, functional evidence of causal interactions between transcription factors. Otherwise, what you have are (at best) correlations. Just saying....
Today on "PI Back In The Lab After A Year", Lindsay tries to change the trap on a Neo Vanquish. Step 1: slack mass spec team and sheepishly confirm that this part is somehow the trap
November 29, 2025 at 8:21 PM
Today on "PI Back In The Lab After A Year", Lindsay tries to change the trap on a Neo Vanquish. Step 1: slack mass spec team and sheepishly confirm that this part is somehow the trap
Watch out, it's that time of year again. The PI is getting back into the lab.
November 26, 2025 at 6:52 PM
Watch out, it's that time of year again. The PI is getting back into the lab.
Reposted by Lindsay K Pino
I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below!
careers.gene.com/us/en/job/20...
careers.gene.com/us/en/job/20...
November 25, 2025 at 12:39 AM
I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below!
careers.gene.com/us/en/job/20...
careers.gene.com/us/en/job/20...
Reposted by Lindsay K Pino
🚨🚨 HIRING ALERT: DATA SCIENCE INTERN (ML / METABOLOMICS) – INDIA (REMOTE) 🚨🚨
🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀
🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!!
🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI
🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀
🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!!
🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI
November 21, 2025 at 7:39 AM
🚨🚨 HIRING ALERT: DATA SCIENCE INTERN (ML / METABOLOMICS) – INDIA (REMOTE) 🚨🚨
🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀
🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!!
🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI
🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀
🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!!
🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI
Reposted by Lindsay K Pino
Watching Lauren Celano talk about the state of jobs in industry. The state of industry is in flux which is due to issues with funding. Funders prefer to support 1 company with a large amount of capital versus 10 companies with less each. ##ABRCMS2025
November 21, 2025 at 3:38 PM
Watching Lauren Celano talk about the state of jobs in industry. The state of industry is in flux which is due to issues with funding. Funders prefer to support 1 company with a large amount of capital versus 10 companies with less each. ##ABRCMS2025
Reposted by Lindsay K Pino
Note that the one repost on X came from me, as well as one of those likes
Taking it at face value, this example suggests that Bluesky is >100x enriched over X for users interested in this topic, which covers the intersection of life science/drug development/bioinformatics/AI
#Bsky #Twitter #Xitter
Taking it at face value, this example suggests that Bluesky is >100x enriched over X for users interested in this topic, which covers the intersection of life science/drug development/bioinformatics/AI
#Bsky #Twitter #Xitter
November 22, 2025 at 6:44 AM
Nice! @nmriley.bsky.social
Know an inspiring early-career chemist? Nominate an early-career chemist for the 2026 Talented 12 at cen.acs.org/sections/tal...
Submit your nomination by January 20, 2026.
#CENT12 #MassSpec #Chemistry
Submit your nomination by January 20, 2026.
#CENT12 #MassSpec #Chemistry
November 21, 2025 at 4:31 AM
Nice! @nmriley.bsky.social
Reposted by Lindsay K Pino
Quick heads up - there will soon be a job posting for a Staff Scientist / Senior Staff Scientist in our lab in Copenhagen to support all our mass spec proteomics adventures!
Great colleagues, lots of cool projects… and you’ll get to work with me 😅
Please DM if you’re interested!
Great colleagues, lots of cool projects… and you’ll get to work with me 😅
Please DM if you’re interested!
November 20, 2025 at 5:09 PM
Quick heads up - there will soon be a job posting for a Staff Scientist / Senior Staff Scientist in our lab in Copenhagen to support all our mass spec proteomics adventures!
Great colleagues, lots of cool projects… and you’ll get to work with me 😅
Please DM if you’re interested!
Great colleagues, lots of cool projects… and you’ll get to work with me 😅
Please DM if you’re interested!
Reposted by Lindsay K Pino
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
November 18, 2025 at 11:03 PM
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
Reposted by Lindsay K Pino
We show that the total #RNA isolated from cell cultures can contain substantial non-RNA glycoconjugates, which was found out to be #glycoproteins (characterized in Kegel et al paper), and those glycoconjugates persist even after protease treatment and rounds of purification.
November 15, 2025 at 3:38 PM
We show that the total #RNA isolated from cell cultures can contain substantial non-RNA glycoconjugates, which was found out to be #glycoproteins (characterized in Kegel et al paper), and those glycoconjugates persist even after protease treatment and rounds of purification.
Reposted by Lindsay K Pino
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Chemical biology 2026
www.embl.org
November 11, 2025 at 5:46 PM
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Reposted by Lindsay K Pino
Okay, #TeamMassSpec, I have a challenge for you: I want to vary the senstivity of my Orbitrap full scan analysis. Part of my chromatogram has very little signal and part has too much. If I set AGC to 1e6 and max IT to 120 ms I get too much signal and have to reduce my injection volume.
November 13, 2025 at 3:41 AM
Okay, #TeamMassSpec, I have a challenge for you: I want to vary the senstivity of my Orbitrap full scan analysis. Part of my chromatogram has very little signal and part has too much. If I set AGC to 1e6 and max IT to 120 ms I get too much signal and have to reduce my injection volume.
Reposted by Lindsay K Pino
Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
November 11, 2025 at 6:55 PM
Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna