Lindsay K Pino
@lindsaykpino.com
#massspectrometry, #proteomics, and #bioinformatics | hiking and coffee | co-founder & CTO @talusbio | opinions my own
Pinned
Lindsay K Pino
@lindsaykpino.com
· Sep 27
Hello! 👋 Most of you are friends from Twitter/X already, but for those new connections, a brief intro:
I'm a #massspectrometry #proteomic scientist 👩🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/
I'm a #massspectrometry #proteomic scientist 👩🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/
Reposted by Lindsay K Pino
We need FAIR practices in data and code sharing (as always), but with vibe coded tools there must be a benchmark comparison. Remember when new proteomics algorithms compared to Mascot and MS-GF+? We need that now. I would point to proteomicsML, but more is needed, and impetus lies with authors.
7/7
7/7
January 30, 2026 at 12:59 PM
We need FAIR practices in data and code sharing (as always), but with vibe coded tools there must be a benchmark comparison. Remember when new proteomics algorithms compared to Mascot and MS-GF+? We need that now. I would point to proteomicsML, but more is needed, and impetus lies with authors.
7/7
7/7
Reposted by Lindsay K Pino
Episode 98? Finally! (I've been busy) With 2026 Gilman Award for Computational Proteomics Award Winner Bill Noble!
January 30, 2026 at 1:56 PM
Episode 98? Finally! (I've been busy) With 2026 Gilman Award for Computational Proteomics Award Winner Bill Noble!
www.nature.com/articles/s41...
@benneely.com was the one who taught me about Jane Richardson, the woman who developed ribbon diagram visualization for the 3D structure of proteins! 👩🔬🧪🍝🧬💻
@benneely.com was the one who taught me about Jane Richardson, the woman who developed ribbon diagram visualization for the 3D structure of proteins! 👩🔬🧪🍝🧬💻
Stories from the scientist who changed how we visualize proteins - Nature Reviews Chemistry
Ahead of her 85th birthday, Jane Richardson, Professor of Biochemistry at Duke University, discussed her life in science from making her own telescope to developing the ribbon diagrams for the 3D stru...
www.nature.com
January 29, 2026 at 3:10 PM
www.nature.com/articles/s41...
@benneely.com was the one who taught me about Jane Richardson, the woman who developed ribbon diagram visualization for the 3D structure of proteins! 👩🔬🧪🍝🧬💻
@benneely.com was the one who taught me about Jane Richardson, the woman who developed ribbon diagram visualization for the 3D structure of proteins! 👩🔬🧪🍝🧬💻
Reposted by Lindsay K Pino
Less than a week until an incredible opportunity for postgraduate students to expand their knowledge of proteomics and #LearnConnectGrowExplore with us at #UPSS2026! The weather forecast is moderate to hot 🌞 with some periodic rain that will hopefully provide some relief!
January 27, 2026 at 11:22 AM
Less than a week until an incredible opportunity for postgraduate students to expand their knowledge of proteomics and #LearnConnectGrowExplore with us at #UPSS2026! The weather forecast is moderate to hot 🌞 with some periodic rain that will hopefully provide some relief!
Reposted by Lindsay K Pino
🚀 Kicking off the year with our first Advanced #MassSpec Seminar!
Join us tomorrow for an exciting session featuring amazing speakers showcasing their recent research in the fields of #Proteomics & #Metabolomics.
This is a great opportunity to see how #MassSpectrometry is driving new discoveries.
Join us tomorrow for an exciting session featuring amazing speakers showcasing their recent research in the fields of #Proteomics & #Metabolomics.
This is a great opportunity to see how #MassSpectrometry is driving new discoveries.
January 27, 2026 at 11:31 AM
🚀 Kicking off the year with our first Advanced #MassSpec Seminar!
Join us tomorrow for an exciting session featuring amazing speakers showcasing their recent research in the fields of #Proteomics & #Metabolomics.
This is a great opportunity to see how #MassSpectrometry is driving new discoveries.
Join us tomorrow for an exciting session featuring amazing speakers showcasing their recent research in the fields of #Proteomics & #Metabolomics.
This is a great opportunity to see how #MassSpectrometry is driving new discoveries.
Reposted by Lindsay K Pino
ASBMB is hiring a Director of Public Affairs to help champion fundamental biomedical research, strengthen relationships with policymakers and elevate science stories that save and improve lives.
Join ASBMB in shaping the future of science advocacy!
➡️ Apply: www.asbmb.org/about/careers
#STEMCareers
Join ASBMB in shaping the future of science advocacy!
➡️ Apply: www.asbmb.org/about/careers
#STEMCareers
Careers at ASBMB
www.asbmb.org
January 23, 2026 at 12:44 AM
ASBMB is hiring a Director of Public Affairs to help champion fundamental biomedical research, strengthen relationships with policymakers and elevate science stories that save and improve lives.
Join ASBMB in shaping the future of science advocacy!
➡️ Apply: www.asbmb.org/about/careers
#STEMCareers
Join ASBMB in shaping the future of science advocacy!
➡️ Apply: www.asbmb.org/about/careers
#STEMCareers
Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social !
--> computationalproteomics.khoury.northeastern.edu
--> computationalproteomics.khoury.northeastern.edu
May Institute – Computation and statistics for mass spectrometry and proteomics
computationalproteomics.khoury.northeastern.edu
January 20, 2026 at 11:26 PM
Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social !
--> computationalproteomics.khoury.northeastern.edu
--> computationalproteomics.khoury.northeastern.edu
Reposted by Lindsay K Pino
Part of me loves how bad this is, but maybe I’m also terrified someone takes it and runs with it. 😬😱
Found on LinkedIn alongside text describing how PCR works. 😂. #TeamMassSpec #massspectrometry #science #badai
January 19, 2026 at 11:13 PM
Part of me loves how bad this is, but maybe I’m also terrified someone takes it and runs with it. 😬😱
Reposted by Lindsay K Pino
This might be the problem.... #TeamMassSpec
January 16, 2026 at 7:35 PM
This might be the problem.... #TeamMassSpec
Reposted by Lindsay K Pino
Another photo from the pump failure. Quite a doozy. On the plus side the service contract will cover this and with the new parts the instrument will be tip-top. This is a Lumos BTW, we use it for DDA HCD/EThcD on immunopeptidome samples.
January 17, 2026 at 10:21 PM
Another photo from the pump failure. Quite a doozy. On the plus side the service contract will cover this and with the new parts the instrument will be tip-top. This is a Lumos BTW, we use it for DDA HCD/EThcD on immunopeptidome samples.
Reposted by Lindsay K Pino
I made a google notebook llm based on this www.nature.com/articles/s41... and new data concerning mRNA - Protein expression correlation over the last year. It even wrote a grant , which you can find in there if anyone wants to submit it ! notebooklm.google.com/notebook/2c7...
January 14, 2026 at 10:25 PM
I made a google notebook llm based on this www.nature.com/articles/s41... and new data concerning mRNA - Protein expression correlation over the last year. It even wrote a grant , which you can find in there if anyone wants to submit it ! notebooklm.google.com/notebook/2c7...
Reposted by Lindsay K Pino
It's an interesting press release as it leaves out that It's the paper that reproduces MAPS by the Searle lab (pubs.acs.org/doi/abs/10.1...).
Here's the link to the paper:
pubs.acs.org/doi/abs/10.1...
Here's the link to the paper:
pubs.acs.org/doi/abs/10.1...
January 14, 2026 at 11:00 PM
It's an interesting press release as it leaves out that It's the paper that reproduces MAPS by the Searle lab (pubs.acs.org/doi/abs/10.1...).
Here's the link to the paper:
pubs.acs.org/doi/abs/10.1...
Here's the link to the paper:
pubs.acs.org/doi/abs/10.1...
Reposted by Lindsay K Pino
Lorne Proteins 2026 🏖️ features Princeton University protein cognoscenti Michael Hecht, designing an artificial proteome with new folds and functions; and Jerelle Joseph, on tractable MD simulations of multiprotein condensates & synthetic condensate engineering.
🔗 Register now www.lorneproteins.org
🔗 Register now www.lorneproteins.org
January 6, 2026 at 11:51 PM
Lorne Proteins 2026 🏖️ features Princeton University protein cognoscenti Michael Hecht, designing an artificial proteome with new folds and functions; and Jerelle Joseph, on tractable MD simulations of multiprotein condensates & synthetic condensate engineering.
🔗 Register now www.lorneproteins.org
🔗 Register now www.lorneproteins.org
VERY well deserved. @rhuttenhain.bsky.social !! Congratulations 🎉
I'm honored to have received the 2025 HUPO Distinguished Service Award (hupo.org/HUPO-Awards-...) with @mlaval6.bsky.social for building a dynamic early career researcher (ECR) community within @hupo-org.bsky.social. Empowering and amplifying ECRs has been deeply meaningful to me—thank you, HUPO.
January 4, 2026 at 11:36 PM
VERY well deserved. @rhuttenhain.bsky.social !! Congratulations 🎉
Reposted by Lindsay K Pino
We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org
Cancer Research Laboratory | Trumanlab | UNC Charlotte | United States
The Trumanlab at UNC Charlotte incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics as well as cell culture technologies to identify novel an...
www.trumanlab.org
January 3, 2026 at 10:23 PM
We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org
Reposted by Lindsay K Pino
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles
Montaño et al. generate an integrated proteomic and cysteine reactivity resource for
the NCI-60 cancer cell line panel, offering quantitative data on over 12,000 proteins
and 36,000 cysteines to enabl...
www.cell.com
January 2, 2026 at 5:10 PM
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
Reposted by Lindsay K Pino
Looking for a fresh start to 2026? Check out the US HUPO Job Board for new open positions in proteomics!
Visit: https://us-hupo.org/US-HUPO-Job-Board
#Proteomics #USHUPO #ProteomicsJobs
Visit: https://us-hupo.org/US-HUPO-Job-Board
#Proteomics #USHUPO #ProteomicsJobs
January 2, 2026 at 8:10 PM
Looking for a fresh start to 2026? Check out the US HUPO Job Board for new open positions in proteomics!
Visit: https://us-hupo.org/US-HUPO-Job-Board
#Proteomics #USHUPO #ProteomicsJobs
Visit: https://us-hupo.org/US-HUPO-Job-Board
#Proteomics #USHUPO #ProteomicsJobs
Reposted by Lindsay K Pino
Is anyone else getting through a terrible project that needs to be done, just so it won't go into next year? 😂
In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat
In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat
December 22, 2025 at 8:58 PM
Is anyone else getting through a terrible project that needs to be done, just so it won't go into next year? 😂
In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat
In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat
Reposted by Lindsay K Pino
Advice I now give to grad students and postdocs in the sciences: Don’t just try to meet and impress senior scientists. They’ll retire soon. Get to know your fellow students - make friends where possible, be colleagues at least. These are the people you’ll be sharing the field with for decades.
December 26, 2025 at 7:01 PM
Advice I now give to grad students and postdocs in the sciences: Don’t just try to meet and impress senior scientists. They’ll retire soon. Get to know your fellow students - make friends where possible, be colleagues at least. These are the people you’ll be sharing the field with for decades.
Reposted by Lindsay K Pino
Excited to share our newest paper in @emboreports.org! We used proximity-labeling proteomics to examine how different disease mutations in SHP2 alter its interactions and localization. This was a huge undertaking led by former graduate student Anne an Vlimmeren.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants - EMBO Reports
Missense mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperacti...
link.springer.com
December 22, 2025 at 7:25 PM
Excited to share our newest paper in @emboreports.org! We used proximity-labeling proteomics to examine how different disease mutations in SHP2 alter its interactions and localization. This was a huge undertaking led by former graduate student Anne an Vlimmeren.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Isopropanol.
Y'all. I forgot the isopropanol soak.
😭
Y'all. I forgot the isopropanol soak.
😭
Unexpectedly quenching and evotip'ping 7x 96-well plates' worth of samples today. It truly is the season.
Watch out, it's that time of year again. The PI is getting back into the lab.
December 24, 2025 at 5:08 PM
Isopropanol.
Y'all. I forgot the isopropanol soak.
😭
Y'all. I forgot the isopropanol soak.
😭
Unexpectedly quenching and evotip'ping 7x 96-well plates' worth of samples today. It truly is the season.
Watch out, it's that time of year again. The PI is getting back into the lab.
December 23, 2025 at 6:59 PM
Unexpectedly quenching and evotip'ping 7x 96-well plates' worth of samples today. It truly is the season.
Reposted by Lindsay K Pino
#AminoAcidAdvent Day 20: Asparagine (Asn; N)
You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷♂️. FYI was asparagiN according to Dayhoff.
You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷♂️. FYI was asparagiN according to Dayhoff.
December 23, 2025 at 1:53 PM
#AminoAcidAdvent Day 20: Asparagine (Asn; N)
You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷♂️. FYI was asparagiN according to Dayhoff.
You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷♂️. FYI was asparagiN according to Dayhoff.
Reposted by Lindsay K Pino
HUPO 2026 is currently being promoted. Sep 27 to Oct 1, 2026, in Singapore.
It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia.
m.youtube.com/watch?v=ckgy...
It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia.
m.youtube.com/watch?v=ckgy...
HUPO2026 Promo
YouTube video by ICS Events
m.youtube.com
December 18, 2025 at 10:45 AM
HUPO 2026 is currently being promoted. Sep 27 to Oct 1, 2026, in Singapore.
It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia.
m.youtube.com/watch?v=ckgy...
It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia.
m.youtube.com/watch?v=ckgy...
Reposted by Lindsay K Pino
Experience in #archaeological #proteomics?
Interested in #Roman economy / organic artefacts?
Background in data analysis for #ZooMS?
Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy
Apply by 12/01/2026
Interested in #Roman economy / organic artefacts?
Background in data analysis for #ZooMS?
Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy
Apply by 12/01/2026
T: 01642 342201
E: [email protected]
tuwpapps.tees.ac.uk
December 16, 2025 at 2:39 PM
Experience in #archaeological #proteomics?
Interested in #Roman economy / organic artefacts?
Background in data analysis for #ZooMS?
Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy
Apply by 12/01/2026
Interested in #Roman economy / organic artefacts?
Background in data analysis for #ZooMS?
Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy
Apply by 12/01/2026