ProteomicsNews (Ben Orsburn)
@proteomicsnews.bsky.social
Assistant Professor at the University of Pittsburgh. What?? Previous industry CSO. Proteomics researcher with time consuming hobbies in scientific outreach. Opinions are often loud and exclusively my own. www.proteomics.rocks (he/him/his/dude)
Reposted by ProteomicsNews (Ben Orsburn)
The Human Cell Line Phosphoproteome Atlas: A Deep Empirical Resource Revealing Kinase Activity Landscapes www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
December 7, 2025 at 9:20 AM
The Human Cell Line Phosphoproteome Atlas: A Deep Empirical Resource Revealing Kinase Activity Landscapes www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
Reposted by ProteomicsNews (Ben Orsburn)
Who has made this 🤣
December 7, 2025 at 1:49 PM
Who has made this 🤣
Reposted by ProteomicsNews (Ben Orsburn)
A sorely needed standard in the plasma proteomics space is now available.
Perfect for benchmarking peptide-level depletion methods.
Perfect for benchmarking peptide-level depletion methods.
News in Proteomics Research blog post | Finally! A ready-to-run human plasma proteomics standard! proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
December 7, 2025 at 9:40 PM
A sorely needed standard in the plasma proteomics space is now available.
Perfect for benchmarking peptide-level depletion methods.
Perfect for benchmarking peptide-level depletion methods.
The anonymouse peer reviewer who recommended my solo article for a paid ESL service owes me a new keyboard. I got nose coffee all over this one. I'm going to laugh about this all day, though.
December 8, 2025 at 3:35 PM
The anonymouse peer reviewer who recommended my solo article for a paid ESL service owes me a new keyboard. I got nose coffee all over this one. I'm going to laugh about this all day, though.
Another weird acid that is better for proteomic sensitivity than formic acid! chemrxiv.org/engage/chemr...
Propionic acid outperforms formic and acetic acid in MS sensitivity for high-flow reversed-phase LC-MS bottom-up proteomics
Formic acid has long been the default acidic additive in reversed-phase LC-MS-based bottom-up proteomics, offering a practical balance between chromatographic performance and electrospray ionization (...
chemrxiv.org
December 1, 2025 at 5:30 PM
Another weird acid that is better for proteomic sensitivity than formic acid! chemrxiv.org/engage/chemr...
Our Ultra2 has a Peak Genius on it. It is compressing(?) every 3-5 seconds with Captivespray. Anyone else have this same setup and know if this normal? It seems weird.
December 1, 2025 at 4:05 PM
Our Ultra2 has a Peak Genius on it. It is compressing(?) every 3-5 seconds with Captivespray. Anyone else have this same setup and know if this normal? It seems weird.
The Foundation on AppleTV is good if you can get past it the fact it has no resemblance to the books you’ve read multiple times, besides character names.
November 30, 2025 at 8:05 PM
The Foundation on AppleTV is good if you can get past it the fact it has no resemblance to the books you’ve read multiple times, besides character names.
Weird read… english.elpais.com/science-tech...
The fall of a prolific science journal exposes the billion-dollar profits of scientific publishing
One of the 15 publications that put out the most studies globally has been expelled from the indexing system for irregularities. Its publisher, Elsevier, has a 38% profit margin that reached $1.5 bill...
english.elpais.com
November 30, 2025 at 12:30 PM
Weird read… english.elpais.com/science-tech...
Reposted by ProteomicsNews (Ben Orsburn)
Have any #proteomics information analysis systems been developed that try to explain experimental results in terms of transcription factors & E3 ligases rather than metabolic/functional pathways?
November 29, 2025 at 3:56 PM
Have any #proteomics information analysis systems been developed that try to explain experimental results in terms of transcription factors & E3 ligases rather than metabolic/functional pathways?
I’m turning down journal reviews if the journal doesn’t update activities to ORCID. I get a lot of requests and I need to prioritize somehow. I ain’t collecting “reviewer certifications” from Genome biology and scientific reports, etc., when Nature Family and ACS give me credit for my time.
November 29, 2025 at 1:50 PM
I’m turning down journal reviews if the journal doesn’t update activities to ORCID. I get a lot of requests and I need to prioritize somehow. I ain’t collecting “reviewer certifications” from Genome biology and scientific reports, etc., when Nature Family and ACS give me credit for my time.
I’m visiting family in a rural red area where soybeans are a big deal, at least as rotational crops. From the road it looks like 3/4 of farms here are for sale. The car we brought doesn’t have a dash cam. I’d post it if I could, it’s unreal.
November 29, 2025 at 1:32 PM
I’m visiting family in a rural red area where soybeans are a big deal, at least as rotational crops. From the road it looks like 3/4 of farms here are for sale. The car we brought doesn’t have a dash cam. I’d post it if I could, it’s unreal.
TMTPro complementary ions might allow high plex DIA proteomics now. Solid 3-plex data here! proteomicsnews.blogspot.com/2025/11/dia-...
DIA Multiplexed proteomics with off-the-shelf TMTPro reagents!
This is obviously interesting - and surprisingly easy to pull off. The data is processed in FragPipe and one of the output sheets is put ...
proteomicsnews.blogspot.com
November 29, 2025 at 1:28 PM
TMTPro complementary ions might allow high plex DIA proteomics now. Solid 3-plex data here! proteomicsnews.blogspot.com/2025/11/dia-...
…cool…. Guess I’m a Linux person now! www.windowslatest.com/2025/11/19/w...
Windows 11 will allow AI apps to access your personal files or folders using File Explorer integration
Windows 11 is testing a new feature that allows apps like Claude and Manus AI to access files stored on your PC using File Explorer.
www.windowslatest.com
November 28, 2025 at 10:46 PM
…cool…. Guess I’m a Linux person now! www.windowslatest.com/2025/11/19/w...
30% overlap in predicted protein regulation vs measured. Maybe everyone should stop predicting and do more measuring? www.nature.com/articles/s41...
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Nature Genetics
Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative...
www.nature.com
November 28, 2025 at 2:29 PM
30% overlap in predicted protein regulation vs measured. Maybe everyone should stop predicting and do more measuring? www.nature.com/articles/s41...
Reposted by ProteomicsNews (Ben Orsburn)
Proteome-wide in silico screening for human protein-protein interactions www.biorxiv.org/cont...
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#proteomics #prot-preprint
November 26, 2025 at 2:20 PM
Proteome-wide in silico screening for human protein-protein interactions www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
Prosit-PTM!! proteomicsnews.blogspot.com/2025/11/pros...
Prosit-PTM! Deep learn modified peptides???
We all know other great protein informatics teams are working on the holy grail for DIA proteomics - deep learning and prediction of modif...
proteomicsnews.blogspot.com
November 26, 2025 at 2:43 PM
Prosit-PTM!! proteomicsnews.blogspot.com/2025/11/pros...
I was like “…how do you make electro spray high resolution…”? www.mdpi.com/1420-3049/30...
www.mdpi.com
November 26, 2025 at 2:42 PM
I was like “…how do you make electro spray high resolution…”? www.mdpi.com/1420-3049/30...
Reposted by ProteomicsNews (Ben Orsburn)
We wrapped up #THEProteomicsShow Alt Proteomics season with Tim Cleland @paleoproteomicist.bsky.social talking paleoproteomics with me and Ben @proteomicsnews.bsky.social. Won't lie, this season was a blast talking about less typical "proteomics". Find it wherever you find fine podcasts or here.
Ep 94 - Alt Proteomics - Dr. Timothy Cleland by The Proteomics Show
For the final episode of the US HUPO sponsored "Alt Proteomics" series highlighting alternative proteomics things, Ben and Ben sit down to talk with Dr. Timothy Cleland, Smithsonian Institution.Keywor...
creators.spotify.com
November 18, 2025 at 7:13 PM
We wrapped up #THEProteomicsShow Alt Proteomics season with Tim Cleland @paleoproteomicist.bsky.social talking paleoproteomics with me and Ben @proteomicsnews.bsky.social. Won't lie, this season was a blast talking about less typical "proteomics". Find it wherever you find fine podcasts or here.
Guess what MS proteomics people! pubs.acs.org/doi/10.1021/...
November 24, 2025 at 8:29 PM
Guess what MS proteomics people! pubs.acs.org/doi/10.1021/...
Reposted by ProteomicsNews (Ben Orsburn)
In case you missed the live #THEProteomicsShow with me and Ben Orsburn @proteomicsnews.bsky.social, it was pretty fun. HUGE thanks to the organizers of #HUPO2025 for inviting us, and for Ken Weke (Univ. of Victoria) for being our guest. Definitely check it out wherever you get podcasts, or here:
The Proteomics Show • A podcast on Spotify for Creators
Ben Orsburn and Ben Neely co-host a podcast series in a “fireside chat” format with prestigious proteomics researchers. The guests are great, the hosts are questionable.
anchor.fm
November 14, 2025 at 2:03 PM
In case you missed the live #THEProteomicsShow with me and Ben Orsburn @proteomicsnews.bsky.social, it was pretty fun. HUGE thanks to the organizers of #HUPO2025 for inviting us, and for Ken Weke (Univ. of Victoria) for being our guest. Definitely check it out wherever you get podcasts, or here:
Reposted by ProteomicsNews (Ben Orsburn)
Excited to see our journal poster at #HUPO2025!
Big thanks to EiC Prof. Dr. Jens R. Coorssen for helping put it up and promoting the journal, and to EBM Dr. Benjamin Orsburn for his support and stopping by. 🧬🥼
@bskytdp.bsky.social
@proteomicsnews.bsky.social
#Proteomics #Proteomes #Proteoforms
Big thanks to EiC Prof. Dr. Jens R. Coorssen for helping put it up and promoting the journal, and to EBM Dr. Benjamin Orsburn for his support and stopping by. 🧬🥼
@bskytdp.bsky.social
@proteomicsnews.bsky.social
#Proteomics #Proteomes #Proteoforms
November 14, 2025 at 2:43 AM
Excited to see our journal poster at #HUPO2025!
Big thanks to EiC Prof. Dr. Jens R. Coorssen for helping put it up and promoting the journal, and to EBM Dr. Benjamin Orsburn for his support and stopping by. 🧬🥼
@bskytdp.bsky.social
@proteomicsnews.bsky.social
#Proteomics #Proteomes #Proteoforms
Big thanks to EiC Prof. Dr. Jens R. Coorssen for helping put it up and promoting the journal, and to EBM Dr. Benjamin Orsburn for his support and stopping by. 🧬🥼
@bskytdp.bsky.social
@proteomicsnews.bsky.social
#Proteomics #Proteomes #Proteoforms
Reposted by ProteomicsNews (Ben Orsburn)
PXD055167 🚨
Mutation of a RAS(ON) G12C-selective inhibitor overcomes acquired resistance to KRAS-GTP inhibitors in NSCLC preclinical models.
🚨 New dataset alert! 🚨
Mutation of a RAS(ON) G12C-selective inhibitor overcomes acquired resistance to KRAS-GTP inhibitors in NSCLC preclinical models.
🚨 New dataset alert! 🚨
November 8, 2025 at 11:00 AM
PXD055167 🚨
Mutation of a RAS(ON) G12C-selective inhibitor overcomes acquired resistance to KRAS-GTP inhibitors in NSCLC preclinical models.
🚨 New dataset alert! 🚨
Mutation of a RAS(ON) G12C-selective inhibitor overcomes acquired resistance to KRAS-GTP inhibitors in NSCLC preclinical models.
🚨 New dataset alert! 🚨
Reposted by ProteomicsNews (Ben Orsburn)
Deciphering microbial and metabolite dynamics in rice noodle fermentation: A metagenomic and untargeted metabolomic approach #FoodChem #MassSpec www.sciencedirect.com/science/arti...
Deciphering microbial and metabolite dynamics in rice noodle fermentation: A metagenomic and untargeted metabolomic approach
Inoculated fermentation accelerates rice noodle production and improves quality, but the underlying microbe-metabolite dynamics remain unclear. This s…
www.sciencedirect.com
November 8, 2025 at 11:35 AM
Deciphering microbial and metabolite dynamics in rice noodle fermentation: A metagenomic and untargeted metabolomic approach #FoodChem #MassSpec www.sciencedirect.com/science/arti...
Reposted by ProteomicsNews (Ben Orsburn)
I'm excited to share new results at #HUPO2025!
I’ll be presenting our latest work on a next-generation DIA search and FDR pipeline that enables sensitive, accurate and scalable proteomic analysis — in just a fraction of the time required by current algorithms.
📍 Poster PV.01.009 — Monday
I’ll be presenting our latest work on a next-generation DIA search and FDR pipeline that enables sensitive, accurate and scalable proteomic analysis — in just a fraction of the time required by current algorithms.
📍 Poster PV.01.009 — Monday
November 8, 2025 at 12:28 PM
I'm excited to share new results at #HUPO2025!
I’ll be presenting our latest work on a next-generation DIA search and FDR pipeline that enables sensitive, accurate and scalable proteomic analysis — in just a fraction of the time required by current algorithms.
📍 Poster PV.01.009 — Monday
I’ll be presenting our latest work on a next-generation DIA search and FDR pipeline that enables sensitive, accurate and scalable proteomic analysis — in just a fraction of the time required by current algorithms.
📍 Poster PV.01.009 — Monday
Reposted by ProteomicsNews (Ben Orsburn)
A De Novo Algorithm for Allele Reconstruction from Oxford Nanopore Amplicon Reads, with Application to CYP2D6 https://www.biorxiv.org/content/10.1101/2025.11.06.687066v1
November 8, 2025 at 12:47 PM
A De Novo Algorithm for Allele Reconstruction from Oxford Nanopore Amplicon Reads, with Application to CYP2D6 https://www.biorxiv.org/content/10.1101/2025.11.06.687066v1