@nephromostapha.bsky.social
Reposted
🧬 C3G
APPEAR-C3G or VALIANT?
📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%
🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org
🦋 join us today on #nephjc
APPEAR-C3G or VALIANT?
📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%
🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org
🦋 join us today on #nephjc
January 13, 2026 at 3:34 PM
🧬 C3G
APPEAR-C3G or VALIANT?
📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%
🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org
🦋 join us today on #nephjc
APPEAR-C3G or VALIANT?
📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%
🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org
🦋 join us today on #nephjc
Is it K1 or K2 ?
doaj.org/article/6e0a...
doaj.org/article/6e0a...
Different vitamin K forms in hemodialysis patients: a simple dietary supplement to battle vascular calcification—randomized controlled trial – DOAJ
Abstract Background and aim Vascular calcification is a significant risk factor for cardiovascular diseases in patients with end-stage renal disease,...
doaj.org
December 8, 2025 at 11:27 AM
Is it K1 or K2 ?
doaj.org/article/6e0a...
doaj.org/article/6e0a...
Reposted
Circulating #Testican-2 and #MGT5A are Markers of #Membranous Nephropathy
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00705-3/fulltext
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00705-3/fulltext
December 5, 2025 at 2:00 PM
Circulating #Testican-2 and #MGT5A are Markers of #Membranous Nephropathy
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00705-3/fulltext
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00705-3/fulltext
journals.lww.com
November 23, 2025 at 12:46 AM
Reposted
AKI-D pearls:
•Gentle UF & individualized Rx-minimize dialytrauma
•⬇️frequency/intensity as recovery starts
•Prevent IDH: 🆒 dialysate + slower UF
•Consider tolerating pre-HD SBP 🆙 to 180 mmHg before starting antihypertensives to avoid recurrent AKI & aid ❤️🩹#KidneyWk
•Gentle UF & individualized Rx-minimize dialytrauma
•⬇️frequency/intensity as recovery starts
•Prevent IDH: 🆒 dialysate + slower UF
•Consider tolerating pre-HD SBP 🆙 to 180 mmHg before starting antihypertensives to avoid recurrent AKI & aid ❤️🩹#KidneyWk
November 8, 2025 at 11:21 PM
AKI-D pearls:
•Gentle UF & individualized Rx-minimize dialytrauma
•⬇️frequency/intensity as recovery starts
•Prevent IDH: 🆒 dialysate + slower UF
•Consider tolerating pre-HD SBP 🆙 to 180 mmHg before starting antihypertensives to avoid recurrent AKI & aid ❤️🩹#KidneyWk
•Gentle UF & individualized Rx-minimize dialytrauma
•⬇️frequency/intensity as recovery starts
•Prevent IDH: 🆒 dialysate + slower UF
•Consider tolerating pre-HD SBP 🆙 to 180 mmHg before starting antihypertensives to avoid recurrent AKI & aid ❤️🩹#KidneyWk
Reposted
Challenges to incorporating new therapies in lupus nephritis:
Access
Burden of immunosuppression
Cost effectiveness
Pill burden - adherence
Long term safety
#KidneyWk
Access
Burden of immunosuppression
Cost effectiveness
Pill burden - adherence
Long term safety
#KidneyWk
November 5, 2025 at 3:41 PM
Challenges to incorporating new therapies in lupus nephritis:
Access
Burden of immunosuppression
Cost effectiveness
Pill burden - adherence
Long term safety
#KidneyWk
Access
Burden of immunosuppression
Cost effectiveness
Pill burden - adherence
Long term safety
#KidneyWk
Reposted
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
October 29, 2025 at 2:59 PM
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
Reposted
Reposted
8/9
🎯 Take-home
Switching from traditional eGFR/ACR-based to KFRE-based referral:
✅ Sharpens referral precision
✅ Cuts unnecessary specialist visits by ~25%
✅ Preserves safety with few missed cases
✅ Aligns with KDIGO 2024 — but suggests higher, locally optimized thresholds
🎯 Take-home
Switching from traditional eGFR/ACR-based to KFRE-based referral:
✅ Sharpens referral precision
✅ Cuts unnecessary specialist visits by ~25%
✅ Preserves safety with few missed cases
✅ Aligns with KDIGO 2024 — but suggests higher, locally optimized thresholds
July 14, 2025 at 12:06 PM
8/9
🎯 Take-home
Switching from traditional eGFR/ACR-based to KFRE-based referral:
✅ Sharpens referral precision
✅ Cuts unnecessary specialist visits by ~25%
✅ Preserves safety with few missed cases
✅ Aligns with KDIGO 2024 — but suggests higher, locally optimized thresholds
🎯 Take-home
Switching from traditional eGFR/ACR-based to KFRE-based referral:
✅ Sharpens referral precision
✅ Cuts unnecessary specialist visits by ~25%
✅ Preserves safety with few missed cases
✅ Aligns with KDIGO 2024 — but suggests higher, locally optimized thresholds
Best approches to fight “silent epdemic” academic.oup.com/ndt/advance-...
July 13, 2025 at 8:20 PM
Best approches to fight “silent epdemic” academic.oup.com/ndt/advance-...
Reposted
The isolated hepatitis B core antibody:
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
The Mystery of the Isolated Hepatitis B Core Antibody, Solved
(A post inspired by years of doing eConsults, an extremely common query about hepatitis B testing, and the latest BritBox series, “Core Antibody Confidential,” starring a grizzled detective with a fad...
blogs.jwatch.org
June 27, 2025 at 9:09 PM
The isolated hepatitis B core antibody:
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
Reposted
“Wound Man” is an illustration which first appeared in European surgical texts during the Middle Ages. It laid out schematically the various wounds a person might suffer in battle or in accidents, with accompanying text stating treatments.
It's Friday! Tag yourself as a wound.
It's Friday! Tag yourself as a wound.
June 27, 2025 at 7:56 AM
“Wound Man” is an illustration which first appeared in European surgical texts during the Middle Ages. It laid out schematically the various wounds a person might suffer in battle or in accidents, with accompanying text stating treatments.
It's Friday! Tag yourself as a wound.
It's Friday! Tag yourself as a wound.