Thomas Nichols
@nichols.bsky.social
2.2K followers 570 following 29 posts
Professor of Neuroimaging Statistics Oxford Big Data Institute Nuffield Department of Population Health University of Oxford
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Reposted by Thomas Nichols
mguindani.bsky.social
𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬 – 𝐒𝐩𝐚𝐭𝐢𝐚𝐥 𝐒𝐭𝐚𝐭𝐢𝐬𝐭𝐢𝐜𝐬 𝐢𝐧 𝐈𝐦𝐚𝐠𝐢𝐧𝐠

Special issue of 𝘚𝘵𝘢𝘵𝘪𝘴𝘵𝘪𝘤𝘴 𝘢𝘯𝘥 𝘋𝘢𝘵𝘢 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘪𝘯 𝘐𝘮𝘢𝘨𝘪𝘯𝘨, supported by @amstatnews.bsky.social ASA Sections on Statistics and the Environment (ENVR) and Statistics in Epidemiology (SIE)

Submission details:
tinyurl.com/47enwhwz
nichols.bsky.social
Well known diagnostic labels (RRMS, SPMS, PPMS) do not explain these states, showing their limitations. This is an important contribution to developing more fully data-driven perspectives on MS disease heterogeneity.
nichols.bsky.social
This is a key output of the Oxford Big Data Institute-Novartis Collaboration for AI in Medicine. The paper represents a huge, collaborative effort, with replication done on data from another pharma company (Roche) and another large dataset (MS PATHS).

www.bdi.ox.ac.uk/research/oxf...
Oxford Novartis Collaboration for AI in Medicine
www.bdi.ox.ac.uk
nichols.bsky.social
Epic work led by Habib Ganjgahi is out in Nature Medicine... data-driven clustering of MS finds 3 distinct states, early/mild, active, advanced, w/ transition to the advanced state only occuring through the active state... replicated twice!

doi.org/10.1038/s415...
nichols.bsky.social
This is a gem… really enjoyed reading about stats theory legend Gauss trudging across the countryside surveying.
Reposted by Thomas Nichols
lhuntneuro.bsky.social
Really nice study, and extends some of the ideas developed in this paper pubmed.ncbi.nlm.nih.gov/32673043/
bttyeo.bsky.social
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social

AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...

doi.org/10.1038/s415...
nichols.bsky.social
For me, this work is a classic @ohbmofficial.bsky.social story: In 2023 I wasn't working with @bttyeo.bsky.social but I overheard him at his poster pointing to some accuracy curves saying "I don't why they have this particular shape". That kicked off the collab that led to these results.
bttyeo.bsky.social
3/11 Tom's model explains empirical prediction accuracies well across 76 phenotypes from 9 resting-fMRI & task-fMRI datasets (R2 = 0.89), spanning many scanners, acquisitions, racial groups, disorders & ages.

Does this mean that we should collect large datasets with short scans?
Reposted by Thomas Nichols
bttyeo.bsky.social
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social

AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...

doi.org/10.1038/s415...
nichols.bsky.social
Wasn't aware of tinyplot... an overlay package to make base R graphics easier to use. While I use ggplot2 for some tasks there are many situations where I prefer base R plotting, and this tool will be super helpful in those seetings.
gmcd.bsky.social
`tinyplot` v0.4.2 is now available on CRAN + R-universe 🎉 Mostly bug fixes, but includes some important integration improvements for Positron IDE users. Release notes: grantmcdermott.com/tinyplot/NEW...

#rstats
Reposted by Thomas Nichols
neurosynth.bsky.social
Excited to share our latest preprint: "Neurosynth Compose: A Web-Based Platform for Flexible and Reproducible Neuroimaging Meta-Analysis"

Here, we cover the why, what, and how of the next generation Neurosynth ecosystem for reproducible neuroimaging meta-analysis.

osf.io/preprints/os...
OSF
osf.io
nichols.bsky.social
Almost recovered from #OHBM2025... has anyone else found the E-posters nearly imposible to find. They are here, discoverable through the app and the browser-link-out button

ww6.aievolution.com/hbm2501/inde...
nichols.bsky.social
Public service announcement: Don’t forget to upload your #OHBM2025 poster PDF, at ww6.aievolution.com/hbm2501/
OHBM - 2025 - Speaker Sign In
ww6.aievolution.com
Reposted by Thomas Nichols
corticalpete.bsky.social
The beta release of SPM-Python is out now! Amazing work by Johan Medrano @johmedr.bsky.social , Yael Balbastre, Yulia Bezsudnova @ybezs.bsky.social and other members of their team. A new era for SPM! #OHBM2025
imagingneuroucl.bsky.social
Drumroll... The SPM team will announce that SPM is now fully accessible from Python! 🐍 Learn more about SPM-Python at the SPM roundtable event (Friday, 1pm) and poster number 1841 at #OHBM2025. Try the beta for yourself at github.com/spm/spm-python [2/7]
GitHub - spm/spm-python: The Python interface to SPM
The Python interface to SPM. Contribute to spm/spm-python development by creating an account on GitHub.
github.com
Reposted by Thomas Nichols
jeanette-mumford.bsky.social
Interested in practical tips for assessing collinearity and why common fixes might not help? Come to the #OHBM2025 oral session Friday at 11:30AM (P2)! I’ll share simulation results and @demidenko.bsky.social will present real data. Also, check out my poster Thursday (1051)!
nichols.bsky.social
Is anyone else at #OHBM2024 educational courses maddened by the lack of time per-course schedule? In the app, the individual talks are listed *alphabetically* by talk title, all with the same start time. Same thing for symposia...
nichols.bsky.social
At #OHBM2025 the Open Science Room has been squeezed and next year is at risk of being dramatically reduced/cut. If you like the OSR please consider signing/sharing this petition! chng.it/yjs4Bnyf9s
@ohbmofficial.bsky.social @ohbmossig.bsky.social
Preserve the Open Science Room at the Organization for Human Brain Mapping Annual Meeting
Can you spare a minute to help this campaign?
chng.it
Reposted by Thomas Nichols
mandymejia.bsky.social
Looking forward to #OHBM2025 in Brisbane next week! My lab is recruiting a postdoc & neuroimaging analyst/developer to support our NIH funded work in fMRI-based Alzheimer's biomarker development (NIA R01AG083919). Email or DM if you want to meet up in Brisbane! www.statmindlab.com/join-us
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What can we do with functional MRI data? For many years, fMRI has been used to discover population-level patterns of brain function, organization and connectivity, and to understand differences in t...
www.statmindlab.com
nichols.bsky.social
Happy to see Julio Peraza's lastest posted, "NiCLIP", using a CLIP model to improve 'reverse inference' prediction of task fMRI results based on peak coordinate data www.biorxiv.org/content/10.1... w/ @angielaird.bsky.social @neurozorro.bsky.social James Kent & JB Poline
www.biorxiv.org
Reposted by Thomas Nichols
fmrib-steve.bsky.social
Happy to see my first first-author paper in Imaging Neuroscience (along with @fmrib-karla.bsky.social and @nichols.bsky.social):

Characterising ongoing brain aging and baseline effects from cross-sectional data

doi.org/10.1162/IMAG...